Abstract:
:In normal development the veg1 tier of the sixth cleavage Strongylocentrotus purpuratus embryo contributes progeny to both ectodermal lineages and portions of the archenteron. Treatment with 18 mM LiCl specifically affects this lineage allocation, reducing or eliminating the veg1 contribution to ectoderm. Less frequently this concentration of lithium causes the progeny of animal blastomeres to contribute to the archenteron.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Cameron RA,Davidson EHdoi
10.1006/dbio.1997.8615subject
Has Abstractpub_date
1997-07-15 00:00:00pages
236-9issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(97)98615-2journal_volume
187pub_type
杂志文章abstract::Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T17...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.02.017
更新日期:2019-05-15 00:00:00
abstract::The 3' penultimate exon (exon 18) of transcripts from the muscle myosin heavy chain (MHC) gene of Drosophila melanogaster is excluded from mRNAs of embryonic and larval muscle, while it is included in mRNAs of adult thoracic muscles. By transforming organisms with the MHC gene 5' end, linked in-frame to the MHC gene 3...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90235-u
更新日期:1991-08-01 00:00:00
abstract::Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.8491
更新日期:1997-03-01 00:00:00
abstract::In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8598
更新日期:1997-07-01 00:00:00
abstract::The formation and maintenance of the highly regular organization of membrane systems and proteins in striated muscle require specific membrane-membrane and membrane-cytoskeleton interactions. The development of T-tubules and sarcoplasmic reticulum (SR) was followed in gastrocnemius muscle fibers from chicken embryos b...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1292
更新日期:1993-11-01 00:00:00
abstract::BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here w...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.048
更新日期:2004-06-01 00:00:00
abstract::FgfrL1, which interacts with Fgf ligands and heparin, is a member of the fibroblast growth factor receptor (Fgfr) family. FgfrL1-deficient mice show two significant alterations when compared to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys. Utilizing gene arrays, qPCR ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.08.016
更新日期:2014-10-15 00:00:00
abstract::Primary sensory olfactory neurons reside in a neuroepithelium lining the nasal cavity and project topographically onto the surface of the olfactory bulb, a rostral extension of the telencephalon. Galectin-1, a bivalent galactose-binding vertebrate lectin, is expressed in the developing rodent olfactory system. In the ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0257
更新日期:1996-10-10 00:00:00
abstract::We describe the characterization and a functional analysis in Xenopus development of RalB, a small G protein. RalB RNA and protein are detectable during oogenesis and early development, but the gene is expressed only weakly in adult tissues. The RalB transcripts are processed by poly(A) extension during oocyte maturat...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9254
更新日期:1999-05-15 00:00:00
abstract::During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9312
更新日期:1999-07-01 00:00:00
abstract::The mammalian thalamus is an essential diencephalic derivative that plays unique roles in processing and relaying sensory and motor information to and from the cerebral cortex. The profile of transcription factors and lineage tracing experiments revealed a spatiotemporal relationship between diencephalic progenitor do...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.12.003
更新日期:2015-02-15 00:00:00
abstract::Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate bord...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.12.015
更新日期:2020-04-15 00:00:00
abstract::Peptide growth factors can initiate changes in cell fate in Xenopus ectodermal explants and induce the formation of mesoderm. Marker genes expressed in mesoderm allow the analysis of whether, or how much, induction has occurred, but do not tell us what molecules are involved in carrying out the response. In this repor...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0158
更新日期:1996-07-10 00:00:00
abstract::During meiotic maturation or after fertilization of invertebrate and vertebrate oocytes, many of the quiescent stored mRNAs are recruited into polysomes. In the clam, Spisula solidissima, such masked messages include the abundant mRNAs encoding cyclin A and the small subunit of ribonucleotide reductase. We have previo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0024
更新日期:1996-01-10 00:00:00
abstract::The mammalian Cone-rod homeobox (Crx) gene is a divergent member of the Otx gene family known to be involved in differentiation and survival of retinal photoreceptors and photoentrainment of circadian rhythms. Zebrafish have two genes in the Otx5/crx orthology class, and we previously showed that crx can transactivate...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.037
更新日期:2004-05-01 00:00:00
abstract::Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunor...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1213
更新日期:1993-08-01 00:00:00
abstract::The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90090-4
更新日期:1986-11-01 00:00:00
abstract::POSH (Plenty of SH3s) has distinct roles as a scaffold for specific c-Jun N-terminal kinase (JNK) signaling modules and as an E3 ubiquitin ligase. The physiological function of POSH remains unclear, however, and its possible involvement in developmental processes motivated the present study wherein the Xenopus ortholo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.07.033
更新日期:2005-10-01 00:00:00
abstract::cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90268-0
更新日期:1988-07-01 00:00:00
abstract::Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of cranial and truncal vascular for...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.07.015
更新日期:2015-10-01 00:00:00
abstract::To gain an understanding of the genes and mechanisms that govern morphogenesis and its evolution, we have analyzed mutations that disrupt this process in a simple model structure, the male tail tip of the rhabditid nematode C. elegans. During the evolution of rhabditid male tails, there have been several independent c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.04.472
更新日期:2006-09-01 00:00:00
abstract::Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9570
更新日期:2000-02-01 00:00:00
abstract::The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior str...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.03.044
更新日期:2008-07-15 00:00:00
abstract::The rabbit ovum seldom becomes polyspermic despite the presence of supernumerary sperm with easy access to the ovum plasma membrane. The purpose of this study was to characterize the role of ovum investments in blocking polyspermy. Ova were inseminated with capacitated sperm in vitro and were fertilized. Early stages ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90241-7
更新日期:1987-04-01 00:00:00
abstract::The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00014-9
更新日期:2003-04-01 00:00:00
abstract::The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.10.020
更新日期:2012-01-01 00:00:00
abstract::Pole cell formation in embryos of the parthenogenetic midge, Smittia sp., can be delayed or inhibited by irradiation of the posterior egg pole with ultraviolet light (uv). This leaves the schedule of nuclear divisions and chromosome eliminations virtually unaffected. However, uv irradiation delays the precocious migra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90236-1
更新日期:1983-12-01 00:00:00
abstract::The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.02.017
更新日期:2010-04-15 00:00:00
abstract::Summary Sentence: Conditional ablation of AP-2 gamma results in a delay in skin development and abnormal expression of p63, K14, K1, filaggrin, repetin and secreted Ly6/Plaur domain containing 1, key genes required for epidermal development and differentiation. The development of the epidermis, a stratified squamous e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.02.017
更新日期:2008-05-01 00:00:00
abstract::Hox genes are well-known master regulators in developmental morphogenesis along the anteroposterior axis of animals. However, the molecular mechanisms by which Hox proteins regulate their target genes and determine cell fates are not fully understood. The silk gland of Bombyx mori is a tubular tissue divided into seve...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.12.002
更新日期:2014-02-01 00:00:00