The developmental expression pattern of a new murine homeo box gene: Hox-2.5.

abstract：:Expression of constitutively active Src protein tyrosine kinase in Xenopus oocytes has been shown to accelerate oocyte maturation suggesting that Src may be involved in meiotic progression. However, meiotic regulation of endogenous Src kinase in oocytes has not been investigated in detail. To address this problem, we ...

journal_title：Developmental biology

authors： Tokmakov A,Iwasaki T,Itakura S,Sato K,Shirouzu M,Fukami Y,Yokoyama S

更新日期：2005-02-15 00:00:00

abstract：:The ciliated band of the Strongylocentrotus purpuratus embryo consists of a columnar epithelium, 3-5 cells wide, which gives rise to a small number of neuroblasts. It arises late in development, as a border separating the squamous epithelial cells of the oral and aboral ectoderm. To determine the lineage origins of th...

journal_title：Developmental biology

authors： Cameron RA,Britten RJ,Davidson EH

更新日期：1993-12-01 00:00:00

abstract：:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. ...

journal_title：Developmental biology

authors： Rayle RE

更新日期：1991-07-01 00:00:00

abstract：:The developmental events of sporulation and fruiting body formation in the prokaryote Myxococcus xanthus are preceded by a stage of massive cell death. Two phenotypically complementable strains of M. xanthus defective in developmental lysis were identified from a group of conditional sporulation mutants. Mixture of th...

journal_title：Developmental biology

authors： Janssen GR,Dworkin M

更新日期：1985-11-01 00:00:00

abstract：:Cadherin-mediated cell-cell interactions are thought to be critical in controlling cell sorting during embryogenesis. Here, we report that chimeric embryos generated with N-cadherin-deficient (N-cadherin(-/-)) embryonic stem cells develop further than embryos completely lacking N-cadherin only when the myocardium cons...

journal_title：Developmental biology

authors： Kostetskii I,Moore R,Kemler R,Radice GL

更新日期：2001-06-01 00:00:00

abstract：:Somatic gonadal niche cells control the survival, differentiation, and proliferation of germline stem cells. The establishment of this niche-stem cell relationship is critical, and yet the precursors to these two cell types are often born at a distance from one another. The simple Caenorhabditis elegans gonadal primor...

journal_title：Developmental biology

authors： Rohrschneider MR,Nance J

更新日期：2013-07-15 00:00:00

abstract：:A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ ...

journal_title：Developmental biology

authors： Thomson JA,Solter D

更新日期：1989-02-01 00:00:00

abstract：:Results of numerous experiments indicate that the transient rise in intracellular Ca2+ following sperm-egg fusion is essential for the subsequent events that constitute egg activation. Some events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to intracellular Ca2+ than other even...

journal_title：Developmental biology

authors： Xu Z,Lefevre L,Ducibella T,Schultz RM,Kopf GS

更新日期：1996-12-15 00:00:00

abstract：:Human MusTRD1alpha1 was isolated as a result of its ability to bind a critical element within the Troponin I slow upstream enhancer (TnIslow USE) and was predicted to be a regulator of slow fiber-specific genes. To test this hypothesis in vivo, we generated transgenic mice expressing hMusTRD1alpha1 in skeletal muscle....

journal_title：Developmental biology

authors： Issa LL,Palmer SJ,Guven KL,Santucci N,Hodgson VR,Popovic K,Joya JE,Hardeman EC

更新日期：2006-05-01 00:00:00

abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

journal_title：Developmental biology

authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

更新日期：1989-12-01 00:00:00

abstract：:We report the embryonic phenotype of muscleblind (mbl), a recently described Drosophila gene involved in terminal differentiation of adult ommatidia. mbl is a nuclear protein expressed late in the embryo in pharyngeal, visceral, and somatic muscles, the ventral nerve cord, and the larval photoreceptor system. All thre...

journal_title：Developmental biology

authors： Artero R,Prokop A,Paricio N,Begemann G,Pueyo I,Mlodzik M,Perez-Alonso M,Baylies MK

更新日期：1998-03-15 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:Global silencing of transcriptional activity in the oocyte genome occurs just before the resumption of meiosis and is a crucial developmental transition at the culmination of oogenesis. Transcriptionally quiescent oocytes rely on stored maternal transcripts to sustain the completion of meiosis, fertilization, and earl...

journal_title：Developmental biology

authors： De La Fuente R,Viveiros MM,Burns KH,Adashi EY,Matzuk MM,Eppig JJ

更新日期：2004-11-15 00:00:00

abstract：:During meiotic maturation or after fertilization of invertebrate and vertebrate oocytes, many of the quiescent stored mRNAs are recruited into polysomes. In the clam, Spisula solidissima, such masked messages include the abundant mRNAs encoding cyclin A and the small subunit of ribonucleotide reductase. We have previo...

journal_title：Developmental biology

authors： Walker J,Dale M,Standart N

更新日期：1996-01-10 00:00:00

abstract：:Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell fate, is an essential developmental mechanism. Similarly, domain and boundary establishment are crucial steps to forming organs during development. Notch signaling is a pathway ideally suited to mediating precise patterning cu...

journal_title：Developmental biology

authors： Sjöqvist M,Andersson ER

更新日期：2019-03-01 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:The Mix/Bix family of paired-like homeobox genes encode evolutionarily conserved, sequence specific, DNA-binding transcription factors that have been implicated in the co-ordination of gene expression, axis formation and cell fate determination during gastrulation in vertebrates. When mutated, these genes give rise to...

journal_title：Developmental biology

authors： Pereira LA,Wong MS,Mei Lim S,Stanley EG,Elefanty AG

更新日期：2012-07-15 00:00:00

abstract：:To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...

journal_title：Developmental biology

authors： Callaway EM,Van Essen DC

更新日期：1989-02-01 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:The Foxl1 gene, which encodes a winged helix transcriptional regulator, is expressed in the mesenchymal layer of developing and mature gastrointestinal tract. Foxl1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the ...

journal_title：Developmental biology

authors： Fukuda K,Yoshida H,Sato T,Furumoto TA,Mizutani-Koseki Y,Suzuki Y,Saito Y,Takemori T,Kimura M,Sato H,Taniguchi M,Nishikawa S,Nakayama T,Koseki H

更新日期：2003-03-15 00:00:00

abstract：:Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate bord...

journal_title：Developmental biology

authors： Pegge J,Tatsinkam AJ,Rider CC,Bell E

更新日期：2020-04-15 00:00:00

abstract：:The lateral line system comprises an array of mechanosensory organs, the neuromasts, distributed over the body surface. Each neuromast consists of a patch of mechanosensory hair cells surrounded by support cells. We show that, in the zebrafish, two proneural genes are essential for differentiation of the hair cells, n...

journal_title：Developmental biology

authors： Sarrazin AF,Villablanca EJ,Nuñez VA,Sandoval PC,Ghysen A,Allende ML

更新日期：2006-07-15 00:00:00

abstract：:In normal development the veg1 tier of the sixth cleavage Strongylocentrotus purpuratus embryo contributes progeny to both ectodermal lineages and portions of the archenteron. Treatment with 18 mM LiCl specifically affects this lineage allocation, reducing or eliminating the veg1 contribution to ectoderm. Less frequen...

journal_title：Developmental biology

authors： Cameron RA,Davidson EH

更新日期：1997-07-15 00:00:00

abstract：:The role of fibronectin in mesoderm cell migration and and the importance of mesoderm migration for gastrulation in Xenopus are examined. To allow for migration, a stable interface must exist between migrating mesoderm cells and the cells of the substrate layer, the blastocoel roof. We show that maintenance of this in...

journal_title：Developmental biology

authors： Winklbauer R,Keller RE

更新日期：1996-08-01 00:00:00

abstract：:A cDNA of the sea urchin Strongylocentrotus purpuratus was identified as encoding polyubiquitin and used to detect a single gene with transcripts containing multiple ubiquitin coding units. Polyubiquitin transcripts exist as a 3.2-kb RNA in polyribosomes and as three higher molecular weight RNAs in purified nuclei. Th...

journal_title：Developmental biology

authors： Nemer M,Rondinelli E,Infante D,Infante AA

更新日期：1991-06-01 00:00:00

abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-01-01 00:00:00

abstract：:Activins are members of the TGF-ss superfamily of secreted growth factors that control a diverse array of processes in vertebrates including endocrine function, cell proliferation, differentiation, immune response and wound repair. In Drosophila, the Activin ligand Dawdle (Daw) has been shown to regulate several aspec...

journal_title：Developmental biology

authors： Ellis JE,Parker L,Cho J,Arora K

更新日期：2010-06-15 00:00:00

abstract：:The lizards are evolutionarily the closest vertebrates to humans that demonstrate the ability to regenerate entire appendages containing cartilage, muscle, skin, and nervous tissue. We previously isolated PAX7-positive cells from muscle of the green anole lizard, Anolis carolinensis, that can differentiate into multin...

journal_title：Developmental biology

authors： Palade J,Djordjevic D,Hutchins ED,George RM,Cornelius JA,Rawls A,Ho JWK,Kusumi K,Wilson-Rawls J

更新日期：2018-01-15 00:00:00

abstract：:Epi 1, a monoclonal antibody, was generated against an epidermal specific epithelial antigen; it does not stain neural epithelium. We have used Epi 1 as a marker to determine when the spatial patterns delineating neural from nonneural epithelium become established. We used ventral ectoderm in a sandwich assay to show ...

journal_title：Developmental biology

authors： Savage R,Phillips CR

更新日期：1989-05-01 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00