Abstract:
:The role of fibronectin in mesoderm cell migration and and the importance of mesoderm migration for gastrulation in Xenopus are examined. To allow for migration, a stable interface must exist between migrating mesoderm cells and the cells of the substrate layer, the blastocoel roof. We show that maintenance of this interface does not depend on fibronectin. We further demonstrate that fibronectin contributes to, but is not essential for, mesoderm cell adhesion to the blastocoel roof. However, interaction with fibronectin is necessary for cell spreading and the formation of lamelliform cytoplasmic protrusions. Apparently, the specific role of fibronectin in mesoderm migration is to control cell protrusive activity. Consequently, when fibronectin function is blocked by GRGDSP peptide or antibodies, mesoderm cell migration is inhibited. Nevertheless, gastrulation proceeds nearly normally in inhibitor-treated embryos. It appears that in Xenopus, mesoderm migration is not essential for gastrulation.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Winklbauer R,Keller REdoi
10.1006/dbio.1996.0174subject
Has Abstractpub_date
1996-08-01 00:00:00pages
413-26issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(96)90174-8journal_volume
177pub_type
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90392-v
更新日期:1990-10-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0498
更新日期:2002-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1325
更新日期:1993-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8672
更新日期:1997-09-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.11.025
更新日期:2011-02-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90069-s
更新日期:1992-12-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.09.021
更新日期:2005-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9514
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2020-02-15 00:00:00
abstract::Cell signaling pathways, such as Wnt, Hedgehog (Hh), Notch, and Hippo, are essential for embryogenesis, organogenesis, and tissue homeostasis. In this study, we analyzed 415 genes involved in these pathways in the allotetraploid frog, Xenopus laevis. Most genes are retained in two subgenomes called L and S (193 homeol...
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2001-09-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2014-06-15 00:00:00
abstract::Rapidly growing human teratocarcinoma cells (Tera-2) can be induced to differentiate into quiescent, nontumorigenic cells expressing neuronal markers. To more closely mimic the in vivo conditions for tumor growth, we grew Tera-2 cells in three-dimensional collagen gel cultures. The undifferentiated cells proliferated ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1016
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