The oncofetal gene Pem specifies a divergent paired class homeodomain.

Abstract:

:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Rayle RE

doi

10.1016/0012-1606(91)90467-h

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

255-7

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(91)90467-H

journal_volume

146

pub_type

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