The oncofetal gene Pem specifies a divergent paired class homeodomain.


:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. The Pem recognition helix also has an isoleucine residue replacing an invariant asparagine residue and shares an asparagine residue at a third position with two other vertebrate homeoproteins, at least one of which binds to DNA only as a dimer.


Dev Biol


Developmental biology


Rayle RE




Has Abstract


1991-07-01 00:00:00














  • Drosophila apc regulates delamination of invasive epithelial clusters.

    abstract::Border Cells in the Drosophila ovaries are a useful genetic model for understanding the molecular events underlying epithelial cell motility. During stage 9 of egg chamber development they detach from neighboring stretched cells and migrate between the nurse cells to reach the oocyte. RNAi screening allowed us to iden...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: De Graeve FM,Van de Bor V,Ghiglione C,Cerezo D,Jouandin P,Ueda R,Shashidhara LS,Noselli S

    更新日期:2012-08-01 00:00:00

  • Development of a muscle actin specified by maternal and zygotic mRNA in ascidian embryos.

    abstract::In this investigation, we characterize the embryonic and adult actins and describe the embryonic expression of a muscle actin in the ascidian Styela. Two-dimensional polyacrylamide gel electrophoresis showed that embryos, tadpole larvae, and adult organs contain three major and two minor isoforms of actin. Two of the ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tomlinson CR,Bates WR,Jeffery WR

    更新日期:1987-10-01 00:00:00

  • Cavitation in the mouse preimplantation embryo: Na/K-ATPase and the origin of nascent blastocoele fluid.

    abstract::This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wiley LM

    更新日期:1984-10-01 00:00:00

  • On the role of the 200-kDa neurofilament protein at the developing neuromuscular junction.

    abstract::To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Donahue SP,Wood JG,English AW

    更新日期:1988-11-01 00:00:00

  • An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells.

    abstract::The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells. This study shows that the 4-kb upstream region of the murine desmin promoter directs expression of a lacZ reporter gene throughout the heart from E7.5 and in skeletal muscle and vascular smooth muscl...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Mericskay M,Parlakian A,Porteu A,Dandré F,Bonnet J,Paulin D,Li Z

    更新日期:2000-10-15 00:00:00

  • Abnormal keratinization in the pupoid fetus (pf/pf) mutant mouse epidermis.

    abstract::During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Fisher C,Dale BA,Kollar EJ

    更新日期:1984-04-01 00:00:00

  • Protein synthetic patterns during the asexual life cycle of Volvox carteri.

    abstract::The polypeptide labeling patterns of somatic cells, gonidia (asexual reproductive cells), embryos, and juvenile spheroids of Volvox carteri cultures synchronized by a light/dark cycle were studied as a function of developmental stage and incubation condition. Specimens were exposed to 35SO=4 for 1-hr periods at select...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kirk DL,Kirk MM

    更新日期:1983-04-01 00:00:00

  • Identification of satellite cells from anole lizard skeletal muscle and demonstration of expanded musculoskeletal potential.

    abstract::The lizards are evolutionarily the closest vertebrates to humans that demonstrate the ability to regenerate entire appendages containing cartilage, muscle, skin, and nervous tissue. We previously isolated PAX7-positive cells from muscle of the green anole lizard, Anolis carolinensis, that can differentiate into multin...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Palade J,Djordjevic D,Hutchins ED,George RM,Cornelius JA,Rawls A,Ho JWK,Kusumi K,Wilson-Rawls J

    更新日期:2018-01-15 00:00:00

  • Cyclin A associates with the fusome during germline cyst formation in the Drosophila ovary.

    abstract::Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lilly MA,de Cuevas M,Spradling AC

    更新日期:2000-02-01 00:00:00

  • Neuron-muscle contact changes presynaptic resting calcium set-point.

    abstract::The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zoran MJ,Funte LR,Kater SB,Haydon PG

    更新日期:1993-07-01 00:00:00

  • Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation.

    abstract::Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Palmieri SL,Peter W,Hess H,Schöler HR

    更新日期:1994-11-01 00:00:00

  • How cells dedifferentiate: a lesson from plants.

    abstract::The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Grafi G

    更新日期:2004-04-01 00:00:00

  • Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis.

    abstract::The thyroid gland synthesizes thyroxine (T4), which passes through the larval tadpole's circulatory system. The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3'-triiodothyronine (T3) in peripheral tissues. An early response to thyroid hormone (TH) in the Xenopus laevis ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Cai L,Brown DD

    更新日期:2004-02-01 00:00:00

  • Mesodermal guidance of pioneer axon growth.

    abstract::Pioneer axons in insect legs are experimentally accessible model systems for the molecular identification and cellular localization of guidance cues regulating the path of axon growth. A detailed study of the Fe2 pioneer axons in the legs of the cockroach was performed to examine the diversity of guidance mechanisms. ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rajan I,Denburg JL

    更新日期:1997-10-15 00:00:00

  • Changes during differentiation in requirements for cAMP for expression of cell-type-specific mRNAs in the cellular slime mold, Dictyostelium discoideum.

    abstract::A number of genes encoding developmentally regulated mRNAs in the cellular slime mold, Dictyostelium discoideum, have been described. Many of these are regulated by cAMP. Analysis of the earliest time at which elevated levels of cAMP can induce the expression of these mRNAs reveals a more complex pattern of regulation...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Oyama M,Blumberg DD

    更新日期:1986-10-01 00:00:00

  • The insulator protein Suppressor of Hairy wing is required for proper ring canal development during oogenesis in Drosophila.

    abstract::Chromatin insulators orchestrate gene transcription during embryo development and cell differentiation by stabilizing interactions between distant genomic sites. Mutations in genes encoding insulator proteins are generally lethal, making in vivo functional analyses of insulator proteins difficult. In Drosophila, howev...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Hsu SJ,Plata MP,Ernest B,Asgarifar S,Labrador M

    更新日期:2015-07-01 00:00:00

  • Roles for scalloped and vestigial in regulating cell affinity and interactions between the wing blade and the wing hinge.

    abstract::The scalloped and vestigial genes are both required for the formation of the Drosophila wing, and recent studies have indicated that they can function as a heterodimeric complex to regulate the expression of downstream target genes. We have analyzed the consequences of complete loss of scalloped function, ectopic expr...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Liu X,Grammont M,Irvine KD

    更新日期:2000-12-15 00:00:00

  • Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm.

    abstract::The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sugi Y,Markwald RR

    更新日期:1996-04-10 00:00:00

  • Wnt signaling during development of the gastrointestinal tract.

    abstract::Wnt signaling pathways have been demonstrated to play important roles in controlling tissue patterning and cell proliferation. In the gastrointestinal tract, mutations that lead to activation of the canonical Wnt pathway through beta-catenin result in familial and sporadic colon cancers. The downstream transcription f...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Theodosiou NA,Tabin CJ

    更新日期:2003-07-15 00:00:00

  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning.

    abstract::BMPRIA is a receptor for bone morphogenetic proteins with high affinity for BMP2 and BMP4. Mouse embryos lacking Bmpr1a fail to gastrulate, complicating studies on the requirements for BMP signaling in germ layer development. Recent work shows that BMP4 produced in extraembryonic tissues initiates gastrulation. Here w...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Davis S,Miura S,Hill C,Mishina Y,Klingensmith J

    更新日期:2004-06-01 00:00:00

  • Regulation of M-phase progression in Chaetopterus oocytes by protein kinase C.

    abstract::We have examined the presence of protein kinase C in oocytes of Chaetopterus pergamentaceus and its role in the initiation of germinal vesicle breakdown (GVBD). First, we demonstrated that the oocytes contain a phospholipid- and calcium-dependent protein kinase, protein kinase C (PKC). Since PKC is the primary intrace...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Eckberg WR,Palazzo RE

    更新日期:1992-02-01 00:00:00

  • Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin.

    abstract::Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Stuelsatz P,Shearer A,Yablonka-Reuveni Z

    更新日期:2014-01-15 00:00:00

  • Complement component C3aR constitutes a novel regulator for chick eye morphogenesis.

    abstract::Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we ana...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Grajales-Esquivel E,Luz-Madrigal A,Bierly J,Haynes T,Reis ES,Han Z,Gutierrez C,McKinney Z,Tzekou A,Lambris JD,Tsonis PA,Del Rio-Tsonis K

    更新日期:2017-08-01 00:00:00

  • Neurogenic cells inhibit the differentiation of cardiogenic cells.

    abstract::In this study, we present evidence that neurogenic cells inhibit the differentiation of cardiogenic cells. When cells of the entire area pellucida at stage 5 were dissociated and reaggregated, the aggregates differentiated into neural tissues and other structures of any germ layer origin, except for heart tissues, des...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Climent S,Sarasa M,Villar JM,Murillo-Ferrol NL

    更新日期:1995-09-01 00:00:00

  • The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers.

    abstract::The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

    更新日期:1997-02-01 00:00:00

  • Dynamics of BMP signaling in limb bud mesenchyme and polydactyly.

    abstract::Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible al...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Norrie JL,Lewandowski JP,Bouldin CM,Amarnath S,Li Q,Vokes MS,Ehrlich LIR,Harfe BD,Vokes SA

    更新日期:2014-09-15 00:00:00

  • Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides.

    abstract::A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Drazba J,Pierce M,Lemmon V

    更新日期:1991-05-01 00:00:00

  • Correct cell-type-specific expression of a fusion gene injected into sea urchin eggs.

    abstract::A fusion gene construct containing the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of CyIIIa actin gene regulatory sequences was injected into unfertilized eggs of the urchin Strongylocentrotus purpuratus, and early pluteus stage embryos that developed from these eggs were fixed and sectio...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Hough-Evans BR,Franks RR,Cameron RA,Britten RJ,Davidson EH

    更新日期:1987-06-01 00:00:00

  • Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development.

    abstract::Mutations in the NF1 gene may cause developmental abnormalities and the formation of a variety of tumors of neural crest origin in humans. The NF1 gene codes for a large protein, neurofibromin (nf), which is structurally and functionally related to yeast and human ras-GTPase-activating proteins (ras-GAPs). Recently, t...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Huynh DP,Nechiporuk T,Pulst SM

    更新日期:1994-02-01 00:00:00

  • XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.

    abstract::Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Cardoso C,Couillault C,Mignon-Ravix C,Millet A,Ewbank JJ,Fontés M,Pujol N

    更新日期:2005-02-01 00:00:00