Evidence for an adrenergic mechanism in the control of body asymmetry.

abstract：:Fertilization-related sperm mitochondrial movement occurs at a rate comparable to other actin-myosin-driven movements and is inhibited by cytochalasin B and N-ethyl maleimide in Ascidia ceratodes sperm. F-actin was demonstrated in the tails and mitochondria using NBD-phallacidin fluorescence. Both actin and myosin wer...

journal_title：Developmental biology

authors： Lambert CC,Lambert G

更新日期：1984-12-01 00:00:00

abstract：:Morphogenesis of the Drosophila tracheal system relies on different signalling pathways that have distinct roles in specifying both the migration of the tracheal cells and the particular morphological features of the primary branches. The current view is that the tracheal cells are initially specified as an equivalent...

journal_title：Developmental biology

authors： Franch-Marro X,Casanova J

更新日期：2002-10-15 00:00:00

abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

journal_title：Developmental biology

authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

更新日期：1998-08-01 00:00:00

abstract：:Monoclonal antibodies highly selective for developmentally regulated antigens present in the cornea (Zak and Linsenmayer, Dev. Biol. 99, 373-381, 1983) have been used to immunohistochemically evaluate differentiation in intact chick corneas cultured on the chorioallantoic membrane (CAM) of host embryos. One antibody i...

journal_title：Developmental biology

authors： Zak NB,Linsenmayer TF

更新日期：1985-04-01 00:00:00

abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

journal_title：Developmental biology

authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

更新日期：2015-06-15 00:00:00

abstract：:Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

journal_title：Developmental biology

authors： Lou X,Bixby JL

更新日期：1993-09-01 00:00:00

abstract：:Using optical imaging assays, we investigated the dynamics of acetylcholine receptors (AChRs) at laminin-associated clusters on cultured myotubes in the absence or presence of the nerve-derived clustering factor, agrin. Using fluorescence recovery after photobleaching (FRAP) on fluorescent bungarotoxin-labeled recepto...

journal_title：Developmental biology

authors： Bruneau EG,Macpherson PC,Goldman D,Hume RI,Akaaboune M

更新日期：2005-12-01 00:00:00

abstract：:During anuran metamorphosis, larval-type myotubes in both trunk and tail are removed by apoptosis, and only trunk muscles are replaced by newly formed adult-type myotubes. In the present study, we clarified the regulatory mechanisms for specific developmental fates of adult and larval muscles. Two distinct (adult and ...

journal_title：Developmental biology

authors： Shimizu-Nishikawa K,Shibota Y,Takei A,Kuroda M,Nishikawa A

更新日期：2002-11-01 00:00:00

abstract：:The development of the vertebrate inner ear is a complex process that has been investigated in several model organisms. In this work, we examined genetic interactions regulating early development of otic structures in medaka. We demonstrate that misexpression of Fgf8, Dlx3b and Foxi1 during early gastrulation is suffi...

journal_title：Developmental biology

authors： Aghaallaei N,Bajoghli B,Czerny T

更新日期：2007-07-15 00:00:00

abstract：:Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

journal_title：Developmental biology

authors： Shin KS,Park JY,Ha DB,Chung CH,Kang MS

更新日期：1996-04-10 00:00:00

abstract：:The olfactory epithelium (OE) of the mouse provides a unique system for understanding how cell birth and cell death interact to regulate neuron number during development and regeneration. We have examined cell death in the OE in normal adult mice; in adult mice subjected to unilateral olfactory bulbectomy (surgical re...

journal_title：Developmental biology

authors： Holcomb JD,Mumm JS,Calof AL

更新日期：1995-11-01 00:00:00

abstract：:Accumulating evidence indicates that the endometrial extracellular matrix (ECM) modulates trophoblast adhesion during mouse blastocyst implantation. In previous studies of adhesion-competent mouse blastocysts, we have demonstrated that integrin-mediated fibronectin (FN)-binding activity on the apical surface of tropho...

journal_title：Developmental biology

authors： Wang J,Mayernik L,Armant DR

更新日期：2002-05-15 00:00:00

abstract：:During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

journal_title：Developmental biology

authors： Moss SB,Challoner PB,Groudine M

更新日期：1989-05-01 00:00:00

abstract：:The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, ...

journal_title：Developmental biology

authors： Lilla JN,Werb Z

更新日期：2010-01-01 00:00:00

abstract：:Retinoic acid (RA) is a potent inducer of cell differentiation and plays an essential role in sex-specific germ cell development in the mammalian gonad. RA is essential for male gametogenesis and hence fertility. However, RA can also disrupt sexual cell fate in somatic cells of the testis, promoting transdifferentiati...

journal_title：Developmental biology

authors： Minkina A,Lindeman RE,Gearhart MD,Chassot AA,Chaboissier MC,Ghyselinck NB,Bardwell VJ,Zarkower D

更新日期：2017-04-15 00:00:00

abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

journal_title：Developmental biology

authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

更新日期：2011-08-01 00:00:00

abstract：:Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...

journal_title：Developmental biology

authors： Nishii K,Morimoto S,Minakami R,Miyano Y,Hashizume K,Ohta M,Zhan DY,Lu QW,Shibata Y

更新日期：2008-10-01 00:00:00

abstract：:Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...

journal_title：Developmental biology

authors： Yoon JK,Olson EN,Arnold HH,Wold BJ

更新日期：1997-08-15 00:00:00

abstract：:Early mammalian embryogenesis is controlled by mechanisms governing the balance between pluripotency and differentiation. The expression of early lineage-specific genes can vary significantly between species, with implications for developmental control and stem cell derivation. However, the mechanisms involved in patt...

journal_title：Developmental biology

authors： Niakan KK,Eggan K

更新日期：2013-03-01 00:00:00

abstract：:Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure and development of a model nociceptor, the PVD neuron of C. elegans, and identify transcription factors that control morphogen...

journal_title：Developmental biology

authors： Smith CJ,Watson JD,Spencer WC,O'Brien T,Cha B,Albeg A,Treinin M,Miller DM 3rd

更新日期：2010-09-01 00:00:00

abstract：:Alkaline phosphatase (AP) activity is expressed by endodermal cells of ascidian larvae. It was reported previously that the expression of AP activity is resistant to treatment with actinomycin D, a transcription inhibitor that inhibits the appearance of several other tissue-specific molecules and morphological markers...

journal_title：Developmental biology

authors： Kumano G,Nishida H

更新日期：1998-06-15 00:00:00

abstract：:Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1(tm1(cre)Skm)), in which the Foxg1 coding region was replaced by the Cre gene....

journal_title：Developmental biology

authors： Kawaguchi D,Sahara S,Zembrzycki A,O'Leary DDM

更新日期：2016-04-01 00:00:00

abstract：:Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...

journal_title：Developmental biology

authors： Raftopoulou M,Hall A

更新日期：2004-01-01 00:00:00

abstract：:Vimentin expression in the lens is striking due to the reported mesenchymal preference of vimentin and the epithelial origin of the lens. The amount of chicken vimentin mRNA levels determined by Northern blot analysis increased 3-fold from 7 to 14 days of embryonic lens development and then decreased 10-fold at 16 day...

journal_title：Developmental biology

authors： Sax CM,Farrell FX,Zehner ZE,Piatigorsky J

更新日期：1990-05-01 00:00:00

abstract：:The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regard...

journal_title：Developmental biology

authors： Wang J,Li S,Chen Y,Ding X

更新日期：2007-04-15 00:00:00

abstract：:The term "transdifferentiation" has been used to describe the apparent phenotypic conversion of chick embryo neural retina Müller glial cells into lens-like cells in vitro. This phenotypic conversion is characterized by expression of such lens-specific proteins as delta crystallin and has been viewed as an example of ...

journal_title：Developmental biology

authors： Linser PJ,Irvin CK

更新日期：1987-06-01 00:00:00

abstract：:Eggs and embryos of the sea urchin Lytechinus pictus were labeled with [35S]methionine. Aqueous extracts of protein were prepared and analyzed by a high resolution two-dimensional polyacrylamide gel electrophoresis system described recently by O'Farrell utilizing isoelectric focusing and sodium dodecyl sulfate electro...

journal_title：Developmental biology

authors： Brandhorst BP

更新日期：1976-09-01 00:00:00

abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...

journal_title：Developmental biology

authors： Carlantoni C,Allanki S,Kontarakis Z,Rossi A,Piesker J,Günther S,Stainier DYR

更新日期：2021-01-01 00:00:00

abstract：:Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastr...

journal_title：Developmental biology

authors： Sawyer JM,Harrell JR,Shemer G,Sullivan-Brown J,Roh-Johnson M,Goldstein B

更新日期：2010-05-01 00:00:00

abstract：:Several genomic clones were isolated from a Drosophila library screened with cDNA prepared from abundant adult female mRNA. Cytoplasmic dot hybridizations have shown that the genes in all of these clones are expressed only in posteclosion (stages 8-14) follicles. One set of overlapping clones (lambda 20, lambda 28, an...

journal_title：Developmental biology

authors： Higgins MJ,Walker VK,Holden JA,White BN

更新日期：1984-09-01 00:00:00