Abstract:
:The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regarding how Wnt signaling functions in this process remain unclear. In this study, we report that Wnt/beta-catenin signaling regulates the expression of Mespo, a basic-helix-loop-helix (bHLH) gene critical for segmental patterning in Xenopus somitogenesis. Transgenic analysis of the Mespo promoter identifies Mespo as a direct downstream target of Wnt/beta-catenin signaling pathway. We also demonstrate that activity of Wnt/beta-catenin signaling in somitogenesis can be enhanced by the PI3-K/AKT pathway. Our results illustrate that Wnt/beta-catenin signaling in conjunction with PI3-K/AKT pathway plays a key role in controlling development of the paraxial mesoderm.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Wang J,Li S,Chen Y,Ding Xdoi
10.1016/j.ydbio.2006.12.034subject
Has Abstractpub_date
2007-04-15 00:00:00pages
836-47issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(06)01490-4journal_volume
304pub_type
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