Abstract:
:We report the patterns of migration of Sertoli cells plated on specific substrata, and the influences of testicular peritubular cells on these processes. Data presented indicate that while peritubular cells readily spread when explanted onto Type I collagen, Sertoli cells do not. A delay of 4 to 6 days occurs after Sertoli cells are plated before they begin to migrate randomly to form plaque-like monolayers on Type I collagen. These processes are dependent upon the synthesis and subsequent deposition of laminin and/or Type IV collagen by Sertoli cells, and are independent of fibronectin. A different behavior occurs when reconstituted mixtures of purified Sertoli cells and pertiubular cells are sparsely plated onto Type I collagen. Peritubular cells rapidly spread to form chains of cells between Sertoli cell aggregates. Sertoli cells then migrate on the surfaces of the peritubular cells, culminating in the formation of cable-like structures between aggregates. Evidence is presented that the Sertoli cell migration to form "cables" under these conditions is dependent upon fibronectin synthesized by peritubular cells, and is independent of the presence of laminin or Type IV collagen. We discuss the possible relevance of these data to the role which precursors of peritubular cells may play in determining the behavior of Sertoli cell precursors in vivo during tubulogenesis, or in the remodelling of the seminiferous tubule which occurs during different stages of the cycle of the seminiferous epithelium in spermatogenesis.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Tung PS,Fritz IBdoi
10.1016/0012-1606(86)90114-4subject
Has Abstractpub_date
1986-01-01 00:00:00pages
119-34issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(86)90114-4journal_volume
113pub_type
杂志文章abstract::Xenopus laevis is among the few species that are capable of fully regenerating a lost lens de novo. This occurs upon removal of the lens, when secreted factors from the retina are permitted to reach the cornea epithelium and trigger it to form a new lens. Although many studies have investigated the retinal factors tha...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.12.036
更新日期:2014-02-15 00:00:00
abstract::A number of genes encoding developmentally regulated mRNAs in the cellular slime mold, Dictyostelium discoideum, have been described. Many of these are regulated by cAMP. Analysis of the earliest time at which elevated levels of cAMP can induce the expression of these mRNAs reveals a more complex pattern of regulation...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90323-4
更新日期:1986-10-01 00:00:00
abstract::Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.02.002
更新日期:2007-05-01 00:00:00
abstract::Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of cranial and truncal vascular for...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.07.015
更新日期:2015-10-01 00:00:00
abstract::Developmental pattern formation allows cells within a tissue or organ to coordinate their development and establish cell types in relationship to one another. To better characterize the developmental patterning events within one organ, the C. elegans hindgut, we have analyzed the expression pattern of several genes us...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00352-x
更新日期:2003-10-01 00:00:00
abstract::The interaction of heterologous tissues involves cell adhesion mediated by the extracellular matrix and its receptor integrins. The Drosophila wing disc is an ectodermal invagination that contacts specific tracheal branches at the basolateral cell surface. We show that an alpha subunit of laminin, encoded by wing blis...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.12.022
更新日期:2007-04-01 00:00:00
abstract::The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90226-5
更新日期:1986-05-01 00:00:00
abstract::An anterior-posterior concentration difference of fibronectin associated with the endoderm in early chick embryos has been implicated in the directional migration of precardiac mesoderm cells. We have examined the effect of increasing concentrations of an antibody to fibronectin (FN) to test the essentiality of FN to ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90378-8
更新日期:1988-10-01 00:00:00
abstract::The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2003.12.027
更新日期:2004-04-01 00:00:00
abstract::The extent to which early differentiation of neurons and muscle cells is autonomous or governed by soluble factors released from other cells has been examined by following development of single cells plated alone in a simple, defined culture medium. The differentiation of electrical excitability and sensitivity to neu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90173-9
更新日期:1986-02-01 00:00:00
abstract::We utilized a strain of mice, derived from a radiation mutagenesis experiment and carrying an activity-attenuated allele of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD), to analyze the development of the cell lineage leading to cerebellar Purkinje neurons. Due to random X inactivation during early embr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0083
更新日期:1996-03-15 00:00:00
abstract::In this paper we present a structural and functional characterization of a new sea urchin embryo transcription factor, SpRunt-1. This factor was isolated by means of its specific interaction with a cis-regulatory target site of the CyIIIa gene. Here we show that this target site, the P7I site, is required for normal e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0050
更新日期:1996-02-25 00:00:00
abstract::To investigate the spatiotemporal dynamics of skin pattern formation, we developed a simple method for artificially disarranging the placement of all three pigment cell types in the body trunk of zebrafish (Danio rerio). We generated transgenic fish with melanophores that ectopically expressed a variant of channelrhod...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.12.019
更新日期:2020-04-01 00:00:00
abstract::The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA factors in a genome-wide transcriptomics analysis. The genes regulated ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.11.017
更新日期:2018-02-01 00:00:00
abstract::Understanding the regulatory circuitry controlling myogenesis is critical to understanding developmental mechanisms and developmentally-derived diseases. We analyzed the transcriptional regulation of a Drosophila myogenic repressor gene, Holes in muscles (Him). Previously, Him was shown to inhibit Myocyte enhancer fac...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.02.005
更新日期:2015-04-15 00:00:00
abstract::Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.07.007
更新日期:2008-10-01 00:00:00
abstract::Aurora A is a mitotic kinase essential for cell proliferation. In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventing studies at later stages of development. Here we report the effects of Aurora A ablation on embryo patterning at early post-implantation stages. Inactivation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.08.010
更新日期:2012-11-01 00:00:00
abstract::Cortical granules of eggs contain a population of heterogeneous proteins that are sequestered selectively within the cortical granule during oogenesis and that participate in the block to polyspermy during the fertilization reaction. To begin to understand the targeting mechanism of proteins to this organelle, we have...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1033
更新日期:1995-01-01 00:00:00
abstract::The ancestral state of animal gastrulation and its bearing for our understanding of bilaterian evolution still is one of the most controversially discussed topics in the field of evolutionary and developmental biology. One hypothesis, the so-called amphistomy scenario, suggests the presence of a slit-like blastopore i...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.04.014
更新日期:2017-07-01 00:00:00
abstract::Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.01.019
更新日期:2013-05-01 00:00:00
abstract::Fertilization overcomes meiotic arrest by triggering a series of biochemical events, resulting in activation of the egg. A small group of protein tyrosine kinases (PTKs) have been identified in eggs of invertebrates and lower vertebrates and inhibitor studies have suggested that they play a role in late events of egg ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8816
更新日期:1998-02-01 00:00:00
abstract::Oligodendrocytes are produced from the same region of the ventral spinal cord that earlier generated motor neurons in bird and rodent embryos. Motor neuron and oligodendrocyte precursor cells express Olig genes, which encode basic helix-loop-helix transcription factors that play important roles in the development of b...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0738
更新日期:2002-08-15 00:00:00
abstract::Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9299
更新日期:1999-07-01 00:00:00
abstract::The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia. To maintain structure and function of the GI tract, regionally diversified differentiation of somatic stem cell (SC) lineages is critical. The adult Drosophila midgut provides an accessible model to study SC regulation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.08.027
更新日期:2016-11-15 00:00:00
abstract::Cardiac neural crest cells undergo extensive cell rearrangements during the formation of the aorticopulmonary septum in the outflow tract. However, the morphogenetic mechanisms involved in this fundamental process remain poorly understood. To determine the function of the Ca2+-dependent cell adhesion molecule, N-cadhe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.09.003
更新日期:2006-11-15 00:00:00
abstract::The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.10.011
更新日期:2014-01-15 00:00:00
abstract::During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.06.030
更新日期:2009-09-01 00:00:00
abstract::We have cloned a member of the fork head/HNF-3 family of transcription factors from the nematode Caenorhabditis elegans. Within the predicted DNA binding domain, this gene, called Ce-fkh-1, is 75-78% identical to the Drosophila fork head and rat liver HNF-3 alpha, beta, and gamma genes. Ce-fkh-1 mRNA is highly enriche...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0219
更新日期:1996-09-15 00:00:00
abstract::The olfactory epithelium (OE) of the mouse provides a unique system for understanding how cell birth and cell death interact to regulate neuron number during development and regeneration. We have examined cell death in the OE in normal adult mice; in adult mice subjected to unilateral olfactory bulbectomy (surgical re...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.0025
更新日期:1995-11-01 00:00:00
abstract::Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.06.023
更新日期:2014-10-01 00:00:00