Cortex glia clear dead young neurons via Drpr/dCed-6/Shark and Crk/Mbc/dCed-12 signaling pathways in the developing Drosophila optic lobe.

abstract：:Macronuclei of Tetrahymena thermophila contain a typical H1 which has been shown to be missing from micronuclei. Instead, micronuclei contain three unique polypeptides, alpha, beta, and gamma, which are associated with linker regions of micronuclear chromatin. In this report polyclonal antibodies raised against macron...

journal_title：Developmental biology

authors： Chicoine LG,Wenkert D,Richman R,Wiggins JC,Allis CD

更新日期：1985-05-01 00:00:00

abstract：:In the full grown oocyte of Xenopus laevis, a sodium permeability can be induced by depolarization to positive potential with current injection. Voltage-clamp analysis has shown that depolarization causes a long-lasting modification of the membrane during which voltage-gated sodium channels become functional. In the p...

journal_title：Developmental biology

authors： Baud C

更新日期：1983-10-01 00:00:00

abstract：:Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in mu...

journal_title：Developmental biology

authors： Thorsteinsdóttir S,Deries M,Cachaço AS,Bajanca F

更新日期：2011-06-15 00:00:00

abstract：:Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

journal_title：Developmental biology

authors： Mason-Suares H,Tie F,Yan CM,Harte PJ

更新日期：2013-08-01 00:00:00

abstract：:This study was undertaken to determine whether premigratory neural crest cells of the axolotl embryo differentiate autonomously into chromatophores, or whether stimuli from the environment, particularly from the extracellular matrix, are required for this process. Neural crest cells were excised from the dorsal part o...

journal_title：Developmental biology

authors： Perris R,Löfberg J

更新日期：1986-02-01 00:00:00

abstract：:In many non-mammalian vertebrates, adult dentitions result from cyclical rounds of tooth regeneration wherein simple unicuspid teeth are replaced by more complex forms. Therefore and by contrast to mammalian models, the numerical majority of vertebrate teeth develop shape during the process of replacement. Here, we ex...

journal_title：Developmental biology

authors： Fraser GJ,Bloomquist RF,Streelman JT

更新日期：2013-05-15 00:00:00

abstract：:The Drosophila boule gene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes. Mutation of boule blocks both meiotic divisions. Differentiation nonetheless continues, re...

journal_title：Developmental biology

authors： Cheng MH,Maines JZ,Wasserman SA

更新日期：1998-12-15 00:00:00

abstract：:To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

journal_title：Developmental biology

authors： Donahue SP,Wood JG,English AW

更新日期：1988-11-01 00:00:00

abstract：:Chick embryonic heart cell isolates and monolayer cultures were prepared from atria and ventricles at selected stages of cardiac development. The cardiac myocytes were assayed for myosin heavy chain (MHC) content using monoclonal antibodies (McAbs) specific in the heart for atrial (B-1), ventricular (ALD-19), or condu...

journal_title：Developmental biology

authors： Zadeh BJ,González-Sánchez A,Fischman DA,Bader DM

更新日期：1986-05-01 00:00:00

abstract：:The molting cycle in insects is regulated by the fluctuating levels of ecdysteroids. Twenty-four hours prior to the pupal molt in Manduca sexta steroid titers are relatively high and they fall to very low levels at 4 hr before the molt. Several physiological events accompanying molts have been shown to require the ris...

journal_title：Developmental biology

authors： Mészáros M,Morton DB

更新日期：1994-04-01 00:00:00

abstract：:P19 embryonal carcinoma cells are multipotential stem cells that differentiate into striated muscle as well as some other cell types when aggregated and exposed to dimethyl sulfoxide (DMSO). Immunofluorescence experiments using monospecific antibodies indicated that the majority of muscle cells were mononucleate and c...

journal_title：Developmental biology

authors： Rudnicki MA,Jackowski G,Saggin L,McBurney MW

更新日期：1990-04-01 00:00:00

abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

journal_title：Developmental biology

authors： Dupin E

更新日期：1984-10-01 00:00:00

abstract：:During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

journal_title：Developmental biology

authors： Moss SB,Challoner PB,Groudine M

更新日期：1989-05-01 00:00:00

abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

journal_title：Developmental biology

authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

更新日期：1986-11-01 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) can be differentiated in culture into either oligodendrocytes or type-2 astrocytes (2As), depending on the culture conditions. Whereas oligodendrocyte development can occur in the absence of inducing signals, 2A development apparently cannot. Fetal calf serum (FCS) and bone morph...

journal_title：Developmental biology

authors： Kondo T,Raff MC

更新日期：2004-03-01 00:00:00

abstract：:During limb development, Sonic hedgehog (SHH) and HOX proteins are considered among the most important factors regulating digit number and identity. SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor. Gli3 mutant limbs are characterized by a severe poly...

journal_title：Developmental biology

authors： Sheth R,Bastida MF,Ros M

更新日期：2007-10-15 00:00:00

abstract：:Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...

journal_title：Developmental biology

authors： Houssin NS,Martin JB,Coppola V,Yoon SO,Plageman TF Jr

更新日期：2020-06-01 00:00:00

abstract：:The cardiac neural crest contains ectomesenchymal and neural anlagen that are necessary for normal heart development. It is not known whether other regions of the neural crest are capable of supporting normal heart development. In the experiments reported herein, quail donor embryos provided cardiac, trunk, or mesence...

journal_title：Developmental biology

authors： Kirby ML

更新日期：1989-08-01 00:00:00

abstract：:Expression of the c-abl proto-oncogene in the mouse testis is characterized by the production of a unique 4.7-kb transcript present in germ cells that have entered the haploid phase of spermatogenesis. A similar developmental stage specificity of expression is observed for a member of the 70-kDa heat-shock protein (hs...

journal_title：Developmental biology

authors： Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1988-02-01 00:00:00

abstract：:The sensory neurons of the Drosophila wing differentiate during the initial stages of metamorphosis, appearing in the imaginal wing disc as it everts and flattens. These identifiable neurons arise in a stereotyped sequence, and lay down a specific pattern of axon bundles which travel proximally to the CNS. In several ...

journal_title：Developmental biology

authors： Blair SS,Palka J

更新日期：1985-04-01 00:00:00

abstract：:Oocytes from LTXBO mice exhibit a delayed entry into anaphase I and frequently enter interphase after the first meiotic division. This unique oocyte model was used to test the hypothesis that protein kinase C (PKC) may regulate the meiosis I-to-meiosis II transition. PKC activity was detected in LTXBO oocytes at proph...

journal_title：Developmental biology

authors： Viveiros MM,Hirao Y,Eppig JJ

更新日期：2001-07-15 00:00:00

abstract：:Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found that CiMRF suppresses both notochord and endoderm develo...

journal_title：Developmental biology

authors： Ratcliffe LE,Asiedu EK,Pickett CJ,Warburton MA,Izzi SA,Meedel TH

更新日期：2019-04-15 00:00:00

abstract：:The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are stil...

journal_title：Developmental biology

authors： Yoshida S,Ohbo K,Takakura A,Takebayashi H,Okada T,Abe K,Nabeshima Y

更新日期：2001-12-15 00:00:00

abstract：:We describe the characterization and a functional analysis in Xenopus development of RalB, a small G protein. RalB RNA and protein are detectable during oogenesis and early development, but the gene is expressed only weakly in adult tissues. The RalB transcripts are processed by poly(A) extension during oocyte maturat...

journal_title：Developmental biology

authors： Moreau J,Lebreton S,Iouzalen N,Mechali M

更新日期：1999-05-15 00:00:00

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:An anterior-posterior concentration difference of fibronectin associated with the endoderm in early chick embryos has been implicated in the directional migration of precardiac mesoderm cells. We have examined the effect of increasing concentrations of an antibody to fibronectin (FN) to test the essentiality of FN to ...

journal_title：Developmental biology

authors： Linask KK,Lash JW

更新日期：1988-10-01 00:00:00

abstract：:Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

journal_title：Developmental biology

authors： Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

更新日期：2009-01-01 00:00:00

abstract：:A cell surface protein (3B11) is differentially expressed in the embryonic labial segment of Manduca as two circular monolayers of epithelial cells invaginate and segregate from surrounding epithelial cells. The cells that invaginate and preferentially express 3B11 represent the presumptive prothoracic glands. These c...

journal_title：Developmental biology

authors： Chen CL,Lampe DJ,Robertson HM,Nardi JB

更新日期：1997-01-01 00:00:00

abstract：:Development and plasticity of synapses are brought about by a complex interplay between various signaling pathways. Typically, either changing the number of synapses or strengthening an existing synapse can lead to changes during synaptic plasticity. Altering the machinery that governs the exocytosis of synaptic vesic...

journal_title：Developmental biology

authors： Wairkar YP,Trivedi D,Natarajan R,Barnes K,Dolores L,Cho P

更新日期：2013-12-01 00:00:00

abstract：:The mesoderm of the sea urchin embryo conventionally is divided into two populations of cells; the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which differentiate into a variety of cell types but do not participate in skeletogenesis. In this study we e...

journal_title：Developmental biology

authors： Ettensohn CA,McClay DR

更新日期：1988-02-01 00:00:00