当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.

The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.

Abstract：

:Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found that CiMRF suppresses both notochord and endoderm development when it is expressed in these tissues by a mechanism that may involve activation of muscle-specific microRNAs. Because these results add to a large body of evidence demonstrating the exceptionally high degree of functional conservation among MRFs, we were surprised to discover that non-ascidian MRFs were not myogenic in Ciona unless they formed part of a chimeric protein containing the CiMRF N-terminus. Equally surprising, we found that despite their widely differing primary sequences, the N-termini of MRFs of other ascidian species could form chimeric MRFs that were also myogenic in Ciona. This domain did not rescue the activity of a Brachyury protein whose transcriptional activation domain had been deleted, and so does not appear to constitute such a domain. Our results indicate that ascidians have previously unrecognized and potentially novel requirements for MRF-directed myogenesis. Moreover, they provide the first example of a domain that is essential to the core function of an important family of gene regulatory proteins, one that, to date, has been found in only a single branch of the family.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Ratcliffe LE,Asiedu EK,Pickett CJ,Warburton MA,Izzi SA,Meedel TH

doi

10.1016/j.ydbio.2018.10.010

subject

Has Abstract

pub_date

2019-04-15 00:00:00

pages

210-225

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(17)30890-4

journal_volume

448

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Tube formation by complex cellular processes in Ciona intestinalis notochord.

    abstract：:In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.03.015

    authors： Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

    更新日期：2009-06-15 00:00:00

  • Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.

    abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.10.045

    authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

    更新日期：2006-03-01 00:00:00

  • Fusion of fibroblasts with differentiated and nondifferentiated leukemia cells resulting in blockage of DNA synthesis.

    abstract：:We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90417-2

    authors： Prudovsky IA,Tsong TY

    更新日期：1991-04-01 00:00:00

  • Nerve signaling regulates basal keratinocyte proliferation in the blastema apical epithelial cap in the axolotl (Ambystoma mexicanum).

    abstract：:The ability of adult vertebrates to repair tissue damage is widespread and impressive; however, the ability to regenerate structurally complex organs such as the limb is limited largely to the salamanders. The fact that most of the tissues of the limb can regenerate has led investigators to question and identify the b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.03.022

    authors： Satoh A,Bryant SV,Gardiner DM

    更新日期：2012-06-15 00:00:00

  • Reexamination of the sequence of the sea urchin egg receptor for sperm: implications with respect to its properties.

    abstract：:A reexamination of the cDNA clones of the Strongylocentrotus purpuratus sea urchin egg receptor for sperm resulted in several important changes to the sequence. By using both rapid amplification of cDNA ends (RACE) and Northern blot analysis for confirmation, the corrected deduced amino acid sequence was shown to lack...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8504

    authors： Just ML,Lennarz WJ

    更新日期：1997-04-01 00:00:00

  • Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.

    abstract：:Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.06.014

    authors： Gard C,Gonzalez Curto G,Frarma YE,Chollet E,Duval N,Auzié V,Auradé F,Vigier L,Relaix F,Pierani A,Causeret F,Ribes V

    更新日期：2017-12-01 00:00:00

  • Outgrowth by fin motor axons in wildtype and a finless mutant of the Japanese medaka fish.

    abstract：:The outgrowth of motor axons to the developing pectoral fin of the Japanese medaka fish (Oryzias latipes) was investigated both in wildtype embryos and in the pectoral finless (pl) mutants in which adults are missing pectoral fins. Late in embryogenesis the pectoral fin is a simple limb which contains two antagonist m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90445-9

    authors： Okamoto H,Kuwada JY

    更新日期：1991-07-01 00:00:00

  • The developmental expression pattern of a new murine homeo box gene: Hox-2.5.

    abstract：:To examine the possible role of homeo box genes in murine development we have studied the structure and expression pattern of Hox-2.5, a newly isolated homeo box gene that maps to the left end of the mouse Hox-2 locus on chromosome 11. The sequence of the Hox-2.5 homeo box has been determined. It is highly homologous ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90056-0

    authors： Bogarad LD,Utset MF,Awgulewitsch A,Miki T,Hart CP,Ruddle FH

    更新日期：1989-06-01 00:00:00

  • Gonadogenesis in Pristionchus pacificus and organ evolution: development, adult morphology and cell-cell interactions in the hermaphrodite gonad.

    abstract：:The nematode gonad is an exemplary system for the study of organogenesis and fundamental problems in developmental and cellular biology. Nematode gonads vary dramatically across species (Chitwood, B.G., Chitwood, M.B., 1950. Introduction to Nematology." University Park Press, Baltimore; Felix, M.A., Sternberg, P.W., 1...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.09.021

    authors： Rudel D,Riebesell M,Sommer RJ

    更新日期：2005-01-01 00:00:00

  • Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.

    abstract：:Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.06.023

    authors： Kono K,Tamashiro DA,Alarcon VB

    更新日期：2014-10-01 00:00:00

  • Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

    abstract：:Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.03.011

    authors： Shimada IS,Somatilaka BN,Hwang SH,Anderson AG,Shelton JM,Rajaram V,Konopka G,Mukhopadhyay S

    更新日期：2019-06-01 00:00:00

  • Tracheal branch repopulation precedes induction of the Drosophila dorsal air sac primordium.

    abstract：:The dorsal air sacs supply oxygen to the flight muscles of the Drosophila adult. This tracheal organ grows from an epithelial tube (the air sac primordium (ASP)) that arises during the third larval instar (L3) from a wing-disc-associated tracheal branch. Since the ASP is generated by a program of both morphogenesis an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.09.005

    authors： Guha A,Kornberg TB

    更新日期：2005-11-01 00:00:00

  • Opposite effects of FGF and BMP-4 on embryonic blood formation: roles of PV.1 and GATA-2.

    abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9205

    authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

    更新日期：1999-04-15 00:00:00

  • Analysis of early human neural crest development.

    abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.012

    authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

    更新日期：2010-08-15 00:00:00

  • Tight regulation of SpSoxB factors is required for patterning and morphogenesis in sea urchin embryos.

    abstract：:Previous studies in sea urchin embryos have demonstrated that nuclearization of beta-catenin is essential for initial steps in the specification of endoderm and mesenchyme, which are derived from vegetal blastomeres. This process begins at the 4th and extends through the 9th cleavage stage, an interval in which the Sp...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00331-2

    authors： Kenny AP,Oleksyn DW,Newman LA,Angerer RC,Angerer LM

    更新日期：2003-09-15 00:00:00

  • spalt-induced specification of distinct dorsal and ventral domains is required for Drosophila tracheal patterning.

    abstract：:Morphogenesis of the Drosophila tracheal system relies on different signalling pathways that have distinct roles in specifying both the migration of the tracheal cells and the particular morphological features of the primary branches. The current view is that the tracheal cells are initially specified as an equivalent...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：

    authors： Franch-Marro X,Casanova J

    更新日期：2002-10-15 00:00:00

  • Genome-wide transcriptomics analysis identifies sox7 and sox18 as specifically regulated by gata4 in cardiomyogenesis.

    abstract：:The transcription factors GATA4, GATA5 and GATA6 are important regulators of heart muscle differentiation (cardiomyogenesis), which function in a partially redundant manner. We identified genes specifically regulated by individual cardiogenic GATA factors in a genome-wide transcriptomics analysis. The genes regulated ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.11.017

    authors： Afouda BA,Lynch AT,de Paiva Alves E,Hoppler S

    更新日期：2018-02-01 00:00:00

  • Inhibition of protein kinases after an induced calcium transient causes transition of bovine oocytes to embryonic cycles without meiotic completion.

    abstract：:We have examined the response of bovine oocytes matured in vitro for 24 hr to parthenogenic activation using compounds that increase intracellular calcium (ionomycin) or inhibit protein phosphorylation (6-dimethylaminopurine, DMAP). Treatment with ionomycin alone caused resumption of meiosis (57.8 +/- 7.8%) but not pr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1351

    authors： Susko-Parrish JL,Leibfried-Rutledge ML,Northey DL,Schutzkus V,First NL

    更新日期：1994-12-01 00:00:00

  • Genetic and molecular analysis of fs(1)h, a maternal effect homeotic gene in Drosophila.

    abstract：:Mutations at the Drosophila melanogaster locus female sterile (1) homeotic (fs(1)h) result in segmental abnormalities including missing organs and homeotic transformations in the progeny of mutant mothers. Homeotic transformations are enhanced when the zygotes carry one of several third chromosome mutations, specifica...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90392-1

    authors： Digan ME,Haynes SR,Mozer BA,Dawid IB,Forquignon F,Gans M

    更新日期：1986-03-01 00:00:00

  • Expression of activin transcripts in follicle cells and oocytes of Xenopus laevis.

    abstract：:Activin is a potent inducer of axial mesoderm in vitro and may have a similar role in vivo. Xenopus laevis eggs contain significant amounts of activin or activin-like factors, but maternal activin transcripts have not been detected in Xenopus eggs. The maternal activin protein might be translated from activin beta A o...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1265

    authors： Rebagliati MR,Dawid IB

    更新日期：1993-10-01 00:00:00

  • Cyclical generation and degeneration of organs in a colonial urochordate involves crosstalk between old and new: a model for development and regeneration.

    abstract：:Botryllus schlosseri is a colonial marine urochordate in which all adult organisms (called zooids) in a colony die synchronously by apoptosis (programmed cell death) in cyclical fashion. During this death phase called takeover, cell corpses within the dying organism are engulfed by circulating phagocytic cells. The "o...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0772

    authors： Lauzon RJ,Ishizuka KJ,Weissman IL

    更新日期：2002-09-15 00:00:00

  • Defining a large set of full-length clones from a Xenopus tropicalis EST project.

    abstract：:Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.04.023

    authors： Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

    更新日期：2004-07-15 00:00:00

  • Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification.

    abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.01.023

    authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

    更新日期：2011-04-15 00:00:00

  • Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line.

    abstract：:A mouse mammary epithelial cell line with morphogenetic properties in vivo, Comma-Dbeta, was used to isolate and to characterize mammary progenitor cells. We found that a homogeneous cell population expressing high surface levels of stem cell antigen 1 (Sca-1) was able to give rise in vivo to ductal and alveolar struc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.02.007

    authors： Deugnier MA,Faraldo MM,Teulière J,Thiery JP,Medina D,Glukhova MA

    更新日期：2006-05-15 00:00:00

  • Differential binding of oocyte-type and somatic-type 5S rRNA to TFIIIA and ribosomal protein L5 in Xenopus oocytes: specialization for storage versus mobilization.

    abstract：:We studied the pathway of 5S ribosomal RNA (rRNA) during oogenesis in Xenopus from its storage in the cytoplasm to incorporation into ribosomes in the nucleus. Ribonucleoprotein particle (RNP) assembly assays reveal striking differences in the behavior of oocyte-type and somatic-type 5S rRNA after microinjection into ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1080

    authors： Allison LA,North MT,Neville LA

    更新日期：1995-04-01 00:00:00

  • Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice.

    abstract：:The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are stil...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0473

    authors： Yoshida S,Ohbo K,Takakura A,Takebayashi H,Okada T,Abe K,Nabeshima Y

    更新日期：2001-12-15 00:00:00

  • A growth-promoting influence from the mesonephros during limb outgrowth.

    abstract：:It has been suggested that the mesonephros has a role in normal limb development. This hypothesis was directly tested by removing the mesonephros adjacent to the presumptive limb region of stage 12-18 chick embryos using microsurgery or laser ablation. The experimental manipulation resulted in reduced limb outgrowth o...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90230-e

    authors： Geduspan JS,Solursh M

    更新日期：1992-05-01 00:00:00

  • Hippo activation through homodimerization and membrane association for growth inhibition and organ size control.

    abstract：:Hippo (Hpo) signaling plays a critical role in restricting tissue growth and organ size in both invertebrate and vertebrate animals. However, how the Hpo kinase is regulated during development has not been clearly understood. Using a Bimolecular Fluorescence Complementation assay, we have investigated the functional s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.017

    authors： Deng Y,Matsui Y,Zhang Y,Lai ZC

    更新日期：2013-03-15 00:00:00

  • Identification of a novel polypeptide involved in the formation of DNA-containing vesicles during macronuclear development in Tetrahymena.

    abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1264

    authors： Madireddi MT,Davis MC,Allis CD

    更新日期：1994-10-01 00:00:00

  • Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development.

    abstract：:Heart valve structures derived from mesenchymal cells of the endocardial cushions (ECs) are composed of highly organized cell lineages and extracellular matrix. Sox9 is a transcription factor required for both early and late stages of cartilage formation that is also expressed in the developing valves of the heart. Th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.02.002

    authors： Lincoln J,Kist R,Scherer G,Yutzey KE

    更新日期：2007-05-01 00:00:00