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Isolation of mouse mammary epithelial progenitor cells with basal characteristics from the Comma-Dbeta cell line.

Abstract：

:A mouse mammary epithelial cell line with morphogenetic properties in vivo, Comma-Dbeta, was used to isolate and to characterize mammary progenitor cells. We found that a homogeneous cell population expressing high surface levels of stem cell antigen 1 (Sca-1) was able to give rise in vivo to ductal and alveolar structures comprising luminal secretory and basal myoepithelial cells. Unlike the Sca-1(high), the Sca-1(neg/low) cell population displayed a reduced morphogenetic potential. The Sca-1(high) cells presented moderate CD24, high CD44 and alpha6 integrin surface levels, expressed basal cell markers p63, keratins 5 and 14, but no luminal and myoepithelial lineage markers. In culture, the Sca-1(high) cells generated identical daughter cells that retained their in vivo developmental potential, indicating that these cells were maintained by self-renewal. Plated at clonogenic density in Matrigel, Sca-1(high) cells formed spheroids that included luminal and myoepithelial cells. Thus, the isolated Sca-1(high) basal cells possess several features of stem/progenitor cells, including specific markers, self-renewal capacity, and the ability to generate the two major mammary lineages, luminal and myoepithelial. These data provide evidence for the existence of basal-type mouse mammary progenitors able to participate in the morphogenetic processes characteristic of mammary gland development.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Deugnier MA,Faraldo MM,Teulière J,Thiery JP,Medina D,Glukhova MA

doi

10.1016/j.ydbio.2006.02.007

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

414-25

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(06)00107-2

journal_volume

293

pub_type

杂志文章

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