Abstract:
:Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the common cardinal vein, pectoral fin, tail, hindbrain, and spinal cord. Analyses of molecular markers suggested that the lateral plate mesoderm is posteriorized in the gir mutant, which is likely to cause the defects of the common cardinal vein and pectoral fin. The cyp26a1 expression in the rostral spinal cord was strongly upregulated in the gir mutant, suggesting a strong feedback control of its expression by RA signaling. We also found that the rostral spinal cord territory was expanded at the expense of the hindbrain territory in the gir mutant. Such a phenotype is the opposite of that of the mutant for Raldh2, an enzyme that synthesizes RA. We propose a model in which Cyp26a1 attenuates RA signaling in the prospective rostral spinal cord to limit the expression of hox genes and to determine the hindbrain-spinal cord boundary.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Emoto Y,Wada H,Okamoto H,Kudo A,Imai Ydoi
10.1016/j.ydbio.2004.11.023subject
Has Abstractpub_date
2005-02-15 00:00:00pages
415-27issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(04)00818-8journal_volume
278pub_type
杂志文章abstract::Male germline stem cells (GSCs) in Drosophila melanogaster divide asymmetrically by orienting the mitotic spindle with respect to the niche, a microenvironment that specifies stem cell identity. The spindle orientation is prepared during interphase through stereotypical positioning of the centrosomes. We recently demo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.10.010
更新日期:2012-01-01 00:00:00
abstract::Chick embryonic heart cell isolates and monolayer cultures were prepared from atria and ventricles at selected stages of cardiac development. The cardiac myocytes were assayed for myosin heavy chain (MHC) content using monoclonal antibodies (McAbs) specific in the heart for atrial (B-1), ventricular (ALD-19), or condu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90241-1
更新日期:1986-05-01 00:00:00
abstract::Coordinated locomotion of Drosophila larvae depends on accurate patterning and stable attachment to the cuticle of both muscles and proprioceptors (chordotonal organs). Unlike muscle spindles in mammals, the fly chordotonal organs are not embedded in the body-wall muscles. Yet, the contractile system (muscles and tend...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.11.022
更新日期:2010-01-15 00:00:00
abstract::In order to disclose the mechanism that regulate synapse development we compared the distributions of agrin, acetylcholine receptors (AChR) and a basal lamina heparan sulfate proteoglycan (HSPG) in sections and cultures prepared from Xenopus laevis and Ambystoma mexicanum embryos. While agrin, AChR and HSPG may accumu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1191
更新日期:1995-07-01 00:00:00
abstract::The elongation of embryo and tissue is a key morphogenetic event in embryogenesis and organogenesis. Notochord, a typical chordate organ, undergoes elongation to perform its regulatory roles and to form the structural support in the embryo. Notochord elongation is morphologically similar across all chordates, but asci...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2018.11.009
更新日期:2019-04-15 00:00:00
abstract::Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.07.003
更新日期:2018-09-01 00:00:00
abstract::Sperm-egg interaction was investigated in mouse eggs freed from the zona pellucida and injected with Clostridium difficile toxin B, the inhibitor of Rho family small G proteins. Toxin B reduced in a dose-dependent manner the percentage of eggs associated with sperm fusion on the surface or sperm nucleus decondensation...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00273-2
更新日期:2003-08-15 00:00:00
abstract::In the absence of maternal expression of the pecanex gene, the embryo develops severe hyperneuralization similar to that characteristic of Notch mutant embryos. We have extended a previous molecular analysis of the chromosomal interval that encompasses pecanex by using additional deficiencies to localize the locus on ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90127-9
更新日期:1989-11-01 00:00:00
abstract::A chronic neuromuscular blockade during those embryonic stages when naturally occurring spinal motoneuron death occurs, results in the prevention of this cell loss. The excess motoneurons are maintained as long as the neuromuscular blockade is continued; once embryonic neuromuscular activity resumes, however, the exce...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90114-3
更新日期:1984-01-01 00:00:00
abstract::Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunor...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1213
更新日期:1993-08-01 00:00:00
abstract::The spectrum of proteins synthesized at different stages of development of the cellular slime mold Dictyostelium discoideum was analyzed by two-dimensional (2D) gel electrophoresis. Of the approximately 400 proteins detected by this method 189 show changes in their relative rate of synthesis. Most of these changes occ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90072-7
更新日期:1985-07-01 00:00:00
abstract::In the deuterostomes and ecdysozoans that have been studied (e.g. chordates and insects), neural fate specification relies on signaling from surrounding cells. However, very little is known about mechanisms of neural specification in the third major bilaterian clade, spiralians. Using blastomere isolation in the annel...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.09.022
更新日期:2017-11-15 00:00:00
abstract::The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fol...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90221-6
更新日期:1986-05-01 00:00:00
abstract::Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.04.001
更新日期:2007-06-15 00:00:00
abstract::The extent to which early differentiation of neurons and muscle cells is autonomous or governed by soluble factors released from other cells has been examined by following development of single cells plated alone in a simple, defined culture medium. The differentiation of electrical excitability and sensitivity to neu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90173-9
更新日期:1986-02-01 00:00:00
abstract::We have investigated the function of the neurogenic gene Notch (N) during development of the adult sensilla of Drosophila. Heat pulses were applied to flies carrying the temperature-sensitive Notch allele Nts1 at different larval and pupal stages. We can show that the reduction of Notch+ function during a short interv...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90147-b
更新日期:1990-11-01 00:00:00
abstract::The neural crest is a transient and multipotent cell population arising at the edge of the neural plate in vertebrates. Recent findings highlight that neural crest patterning is initiated during gastrulation, i.e. earlier than classically described, in a progenitor domain named the neural border. This chapter reviews ...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2012.01.013
更新日期:2012-06-01 00:00:00
abstract::Neural crest cells migrate extensively through a complex extracellular matrix (ECM) to sites of terminal differentiation. To determine what role the various components of the ECM may play in crest morphogenesis, quail (Coturnix coturnix japonica) neural crest cells have been cultured in three-dimensional hydrated coll...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90094-0
更新日期:1984-08-01 00:00:00
abstract::The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90277-x
更新日期:1984-09-01 00:00:00
abstract::To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9975
更新日期:2001-01-01 00:00:00
abstract::Neuronal differentiation requires a coordinated intracellular response to diverse extracellular stimuli, but the role of specific signaling mechanisms in regulating this process is still poorly understood. Soluble guanylate cyclases (sGCs), which can be stimulated by diffusible free radical gasses such as nitric oxide...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.9066
更新日期:1998-12-01 00:00:00
abstract::The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90188-7
更新日期:1989-10-01 00:00:00
abstract::Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.03.012
更新日期:2014-06-15 00:00:00
abstract::The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.05.500
更新日期:2010-09-01 00:00:00
abstract::During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein dis...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.02.019
更新日期:2010-05-01 00:00:00
abstract::The location, timing and intensity of Nodal signalling are all critical for proper patterning of the vertebrate embryo. Genetic evidence from mouse and zebrafish indicates that EGF-CFC family members are essential for Nodal ligands to signal. However, the Xenopus EGF-CFC, FRL1, has been implicated in Wnt signalling an...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.01.006
更新日期:2006-04-15 00:00:00
abstract::Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2018.12.004
更新日期:2019-07-01 00:00:00
abstract::Nematodes provide a useful experimental system with which to investigate the evolution of development at the cellular, genetic, and molecular levels. Building on an understanding of vulval development in Caenorhabditis elegans, analysis of vulval development has been extended to a number of other species in three fami...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1006/dbio.1996.0035
更新日期:1996-02-01 00:00:00
abstract::Monoclonal antibodies (mAbs), electrophoresis, immunoblotting, and immunohistochemistry were used to determine the molecular properties of cardiac myosin heavy chain (MHC) isoforms and the regions of the developing chicken heart in which they were expressed. Adult atria expressed three electrophoretically distinct MHC...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90324-7
更新日期:1988-06-01 00:00:00
abstract::Intestinal tract development is a coordinated process involving signaling among the progenitors and developing cells from all three germ layers. Development of endoderm-derived intestinal epithelium has been shown to depend on epigenetic modifications, but whether that is also the case for intestinal tract cell types ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.08.002
更新日期:2019-11-15 00:00:00