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Translocation of cAMP-dependent protein kinase to the nucleus during development of Dictyostelium discoideum.

Abstract：

:The distribution of the catalytic and regulatory subunits of the cAMP-dependent protein kinase between cytoplasm and nucleus was determined during the development of Dictyostelium discoideum. In vegetative amoebae approximately 2% of the subunits were in the nucleus. During development there was an approximately 5-fold increase in total soluble cAMP-dependent protein kinase and a 15- to 30-fold increase of enzyme in the nuclear fraction. There was a reverse translocation from nucleus to cytoplasm, when Tipped Aggregates were disrupted and the resultant amoebae incubated in single-cell suspension. The addition of cAMP to these single-cell suspensions brought about the reentry of the subunits into the nucleus. The findings are discussed in relation to the potential role of the cAMP-dependent protein kinase in the regulation of mRNA and protein synthesis.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Woffendin C,Chambers TC,Schaller KL,Leichtling BH,Rickenberg HV

doi

10.1016/0012-1606(86)90221-6

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

1-8

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(86)90221-6

journal_volume

115

pub_type

杂志文章

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