Abstract:
:Neonatal mouse hearts fully regenerate after ventricular resection similar to adult zebrafish. We established cryoinjury models to determine if different types and varying degrees of severity in cardiac injuries trigger different responses in neonatal mouse hearts. In contrast to ventricular resection, neonatal mouse hearts fail to regenerate and show severe impairment of cardiac function post transmural cryoinjury. However, neonatal hearts fully recover after non-transmural cryoinjury. Interestingly, cardiomyocyte proliferation does not significantly increase in neonatal mouse hearts after cryoinjuries. Epicardial activation and new coronary vessel formation occur after cryoinjury. The profibrotic marker PAI-1 is highly expressed after transmural but not non-transmural cryoinjuries, which may contribute to the differential scarring. Our results suggest that regenerative medicine strategies for heart injuries should vary depending on the nature of the injury.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Darehzereshki A,Rubin N,Gamba L,Kim J,Fraser J,Huang Y,Billings J,Mohammadzadeh R,Wood J,Warburton D,Kaartinen V,Lien CLdoi
10.1016/j.ydbio.2014.12.018subject
Has Abstractpub_date
2015-03-01 00:00:00pages
91-99issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(14)00648-4journal_volume
399pub_type
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