Sohlh1 is essential for spermatogonial differentiation.

abstract：:The regulation of early embryonic development in the amphibian Xenopus laevis depends largely upon translational and post-translational regulatory mechanisms to direct the complex cytodifferentiations that take place during early cleavage and blastula formation. The cell cycle dependence of protein synthesis was exami...

journal_title：Developmental biology

authors： Kanki JP,Newport JW

更新日期：1991-07-01 00:00:00

abstract：:Eggs and embryos of the sea urchin Lytechinus pictus were labeled with [35S]methionine. Aqueous extracts of protein were prepared and analyzed by a high resolution two-dimensional polyacrylamide gel electrophoresis system described recently by O'Farrell utilizing isoelectric focusing and sodium dodecyl sulfate electro...

journal_title：Developmental biology

authors： Brandhorst BP

更新日期：1976-09-01 00:00:00

abstract：:Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohis...

journal_title：Developmental biology

authors： Sallin P,de Preux Charles AS,Duruz V,Pfefferli C,Jaźwińska A

更新日期：2015-03-01 00:00:00

abstract：:Macronuclei of Tetrahymena thermophila contain a typical H1 which has been shown to be missing from micronuclei. Instead, micronuclei contain three unique polypeptides, alpha, beta, and gamma, which are associated with linker regions of micronuclear chromatin. In this report polyclonal antibodies raised against macron...

journal_title：Developmental biology

authors： Chicoine LG,Wenkert D,Richman R,Wiggins JC,Allis CD

更新日期：1985-05-01 00:00:00

abstract：:Drosophila nemo (nmo) and other Nemo-like kinase family members (Nlks) are well-established key regulators of numerous conserved signaling pathways, such as Wg and BMP. nmo mutants display pleiotropic defects at different developmental stages, including the embryo. In this study we describe a detailed characterization...

journal_title：Developmental biology

authors： Braid LR,Lee W,Uetrecht AC,Swarup S,Papaianni G,Heiler A,Verheyen EM

更新日期：2010-07-01 00:00:00

abstract：:Vasa is a DEAD-box RNA helicase that functions in translational regulation of specific mRNAs. In many animals it is essential for germ line development and may have a more general stem cell role. Here we identify vasa in two sea urchin species and analyze the regulation of its expression. We find that vasa protein acc...

journal_title：Developmental biology

authors： Voronina E,Lopez M,Juliano CE,Gustafson E,Song JL,Extavour C,George S,Oliveri P,McClay D,Wessel G

更新日期：2008-02-15 00:00:00

abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

journal_title：Developmental biology

authors： Bejarano F,Milán M

更新日期：2009-03-15 00:00:00

abstract：:Changes in the intracellular free calcium levels in the cortical region of cleaving Xenopus eggs were examined using semi-synthetic aequorin. We detected periodic oscillations in the free calcium levels accompanying the cleavage cycle as early as the first cleavage onward. The calcium levels began to increase at early...

journal_title：Developmental biology

authors： Kubota HY,Yoshimoto Y,Hiramoto Y

更新日期：1993-12-01 00:00:00

abstract：:The mature heart valves and septa are derived from the cardiac cushions which initially form as local outgrowths of mesenchymal cells within the outflow tract and atrioventricular regions. Endocardial cells respond to signals from the overlying myocardium and undergo an epithelial-to-mesenchymal transformation to inva...

journal_title：Developmental biology

authors： Kim RY,Robertson EJ,Solloway MJ

更新日期：2001-07-15 00:00:00

abstract：:We have cloned a Caenorhabditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hunchback-like). hbl-1 encodes a predicted 982-amino-acid protein, containing two putative zinc-finger domains similar to those of Drosophila Hunchback. The gene is transcribed embryonically, but u...

journal_title：Developmental biology

authors： Fay DS,Stanley HM,Han M,Wood WB

更新日期：1999-01-15 00:00:00

abstract：:Microtubule organization during the novel cell division of ameiotic microsporocytes was examined using indirect immunofluorescence microscopy. A recessive mutation of the maize gene Ameiotic causes the replacement of meiosis I with a synchronized mitotic division (Palmer, R. G. (1971). Chromosoma 35, 233-246). All ide...

journal_title：Developmental biology

authors： Staiger CJ,Cande WZ

更新日期：1992-11-01 00:00:00

abstract：:The Wnt pathways are evolutionarily well-conserved signal transduction pathways that are known to play important roles in all Metazoans investigated to date. Here, we examine the Wnt pathway genes and target genes present in the genome of the echinoderm Strongylocentrotus purpuratus. Analysis of the Wnt genes revealed...

journal_title：Developmental biology

authors： Croce JC,Wu SY,Byrum C,Xu R,Duloquin L,Wikramanayake AH,Gache C,McClay DR

更新日期：2006-12-01 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

journal_title：Developmental biology

authors： Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

更新日期：2011-03-01 00:00:00

abstract：:Eggs have developed their own strategies for early development. Amphibian, teleost fish, and ascidian eggs show cortical rotation and an accompanying structure, a cortical parallel microtubule (MT) array, during the one-cell embryonic stage. Cortical rotation is thought to relocate maternal deposits to a certain compa...

journal_title：Developmental biology

authors： Nishikata T,Goto T,Yagi H,Ishii H

更新日期：2019-04-15 00:00:00

abstract：:N-cadherin is a Ca2+-dependent cell-cell adhesion molecule, which was identified in brain cells of mouse and chicken. In the present study, we have determined the pattern of expression of N-cadherin in chicken embryos at various stages by means of immunohistochemistry. N-cadherin was expressed in cells derived from al...

journal_title：Developmental biology

authors： Hatta K,Takagi S,Fujisawa H,Takeichi M

更新日期：1987-03-01 00:00:00

abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

journal_title：Developmental biology

authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

更新日期：1999-04-15 00:00:00

abstract：:We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the bra...

journal_title：Developmental biology

authors： Woods DF,Bryant PJ

更新日期：1989-07-01 00:00:00

abstract：:Boundary formation is an important mechanism of development and has been studied in a number of bilaterian model organisms where it is often controlled by Notch, FGF and Wnt signalling. Tissue boundaries are also formed in simple pre-bilaterian animals. The boundary between parent and bud during asexual reproduction i...

journal_title：Developmental biology

authors： Münder S,Käsbauer T,Prexl A,Aufschnaiter R,Zhang X,Towb P,Böttger A

更新日期：2010-08-01 00:00:00

abstract：:The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

journal_title：Developmental biology

authors： Sprecher SG,Cardona A,Hartenstein V

更新日期：2011-10-01 00:00:00

abstract：:During meiotic maturation or after fertilization of invertebrate and vertebrate oocytes, many of the quiescent stored mRNAs are recruited into polysomes. In the clam, Spisula solidissima, such masked messages include the abundant mRNAs encoding cyclin A and the small subunit of ribonucleotide reductase. We have previo...

journal_title：Developmental biology

authors： Walker J,Dale M,Standart N

更新日期：1996-01-10 00:00:00

abstract：:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...

journal_title：Developmental biology

authors： DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

更新日期：1997-02-01 00:00:00

abstract：:Fertilization results in the tyrosine phosphorylation of several egg proteins within minutes of sperm-egg binding and inhibitor studies have shown that tyrosine kinase activity is required for many aspects of egg activation. The present study demonstrates the presence of p59c-fyn kinase in the sea urchin egg and exami...

journal_title：Developmental biology

authors： Kinsey WH

更新日期：1996-03-15 00:00:00

abstract：:The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

journal_title：Developmental biology

authors： Fajardo MA,Haugen HS,Clegg CH,Braun RE

更新日期：1997-11-01 00:00:00

abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

journal_title：Developmental biology

authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

更新日期：2004-10-15 00:00:00

abstract：:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...

journal_title：Developmental biology

authors： Tremblay KD,Zaret KS

更新日期：2005-04-01 00:00:00

abstract：:The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

journal_title：Developmental biology

authors： Pennimpede T,Cameron DA,MacLean GA,Petkovich M

更新日期：2010-03-01 00:00:00

abstract：:Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse between organisms, the RNA binding protein Nanos is consistently required in the germ line in all species tested. How Nanos is selectively expressed in the germ line...

journal_title：Developmental biology

authors： Oulhen N,Swartz SZ,Wang L,Wikramanayake A,Wessel GM

更新日期：2019-08-01 00:00:00

abstract：:Temperature sex determining species offer a model for investigating how environmental cues become integrated to the regulation of patterning genes and growth, among bipotential gonads. Manipulation of steroid hormones has revealed the important role of aromatase in the regulation of the estrogen levels involved in tem...

journal_title：Developmental biology

authors： Díaz-Hernández V,Marmolejo-Valencia A,Merchant-Larios H

更新日期：2015-12-01 00:00:00

abstract：:We determined expression and function of a cell membrane protein in the developing chick retinotectal system identified by a monoclonal antibody (mAb 4H5) and the corresponding antiserum. Our data revealed that the protein shares a series of properties, including the N-terminal amino acid sequence, with a cell adhesio...

journal_title：Developmental biology

authors： Pollerberg GE,Mack TG

更新日期：1994-10-01 00:00:00

abstract：:T-box family transcription factors play many roles in Metazoan development. Here we characterise Tbx6r, a unique Tbx6 paralogue isolated from the amphibian Xenopus. The evolution and developmental integration of this divergent T-box gene within the vertebrates reveals an unexpected level of plasticity within this cons...

journal_title：Developmental biology

authors： Callery EM,Thomsen GH,Smith JC

更新日期：2010-04-01 00:00:00