A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.

abstract：:Mouse embryo limb cells carrying either the brachypodism (bpH/bpH) mutation or its wild-type (+/+) allele were tested for their ability to accumulate cyclic AMP in response to prostaglandin E2 (PGE2) between Embryonic Days E12 and E14. Mutant cells exhibited a precocious increase in cyclic AMP. In the absence of PGE2 ...

journal_title：Developmental biology

authors： Ballard TA,Elmer WA

更新日期：1990-12-01 00:00:00

abstract：:Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

journal_title：Developmental biology

authors： Li J,Rao H,Burkin D,Kaufman SJ,Wu C

更新日期：2003-09-01 00:00:00

abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

journal_title：Developmental biology

authors： Loomis WF

更新日期：2014-07-01 00:00:00

abstract：:Mutations at the murine steel (Sl) locus encoding the ligand for the c-kit receptor result in defects in gametogenesis, hematopoiesis, and melanogenesis. Steel Panda (Slpan) is an allele at the Sl locus obtained by an X-ray mutagenesis protocol. Slpan/Slpan homozygotes are mildly anemic black-eyed whites with pigmente...

journal_title：Developmental biology

authors： Huang EJ,Manova K,Packer AI,Sanchez S,Bachvarova RF,Besmer P

更新日期：1993-05-01 00:00:00

abstract：:Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

journal_title：Developmental biology

authors： Shin KS,Park JY,Ha DB,Chung CH,Kang MS

更新日期：1996-04-10 00:00:00

abstract：:The extent to which early differentiation of neurons and muscle cells is autonomous or governed by soluble factors released from other cells has been examined by following development of single cells plated alone in a simple, defined culture medium. The differentiation of electrical excitability and sensitivity to neu...

journal_title：Developmental biology

authors： Henderson LP,Spitzer NC

更新日期：1986-02-01 00:00:00

abstract：:Pax3/7 paired homeodomain transcription factors are important markers of muscle stem cells. Pax3 is required upstream of myod for lateral dermomyotomal cells in the amniote somite to form particular muscle cells. Later Pax3/7-dependent cells generate satellite cells and most body muscle. Here we analyse early myogenes...

journal_title：Developmental biology

authors： Hammond CL,Hinits Y,Osborn DP,Minchin JE,Tettamanti G,Hughes SM

更新日期：2007-02-15 00:00:00

abstract：:Superior cervical ganglia of postnatal mice with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild-type mice. In culture, neurotrophin-3 increases the survival of proliferating sympathetic precursors. Both precursor death (W. ElShamy et al., 1996, Development 122, 491-500) ...

journal_title：Developmental biology

authors： Francis N,Farinas I,Brennan C,Rivas-Plata K,Backus C,Reichardt L,Landis S

更新日期：1999-06-15 00:00:00

abstract：:Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...

journal_title：Developmental biology

authors： Kono K,Tamashiro DA,Alarcon VB

更新日期：2014-10-01 00:00:00

abstract：:In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found th...

journal_title：Developmental biology

authors： Fischer AJ,Reh TA

更新日期：2000-04-15 00:00:00

abstract：:Skeletal muscle development (myogenesis) is a complex but precisely orchestrated process involving spatiotemporal regulation of the proliferation, differentiation and fusion of myogenic progenitor cells (myoblasts). Here we identify brain expressed x-linked gene 1 (Bex1) as a transient, developmentally regulated gene ...

journal_title：Developmental biology

authors： Jiang C,Wang JH,Yue F,Kuang S

更新日期：2016-01-01 00:00:00

abstract：:We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have...

journal_title：Developmental biology

authors： Shepherd IT,Beattie CE,Raible DW

更新日期：2001-03-15 00:00:00

abstract：:An important developmental question concerns whether neurotransmitter phenotype is an inherent property of neurons or is influenced by target tissues. This issue can be addressed in the avian ciliary ganglion (CG) which contains two cholinergic populations, ciliary and choroid neurons, that differentially express the ...

journal_title：Developmental biology

authors： Darland DC,Nishi R

更新日期：1998-10-15 00:00:00

abstract：:Members of the basic helix-loop-helix family of DNA binding proteins have important roles in the development of subpopulations of neural crest-derived neurons. We have cloned the chicken homologues of dHAND (HAND2) and eHAND (HAND1), basic helix-loop-helix DNA binding proteins whose neuronal expression is restricted t...

journal_title：Developmental biology

authors： Howard M,Foster DN,Cserjesi P

更新日期：1999-11-01 00:00:00

abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...

journal_title：Developmental biology

authors： Jones D,Candido EP

更新日期：2000-10-01 00:00:00

abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

journal_title：Developmental biology

authors： Carlson JR,Hogness DS

更新日期：1985-04-01 00:00:00

abstract：:Changes in the intracellular free calcium levels in the cortical region of cleaving Xenopus eggs were examined using semi-synthetic aequorin. We detected periodic oscillations in the free calcium levels accompanying the cleavage cycle as early as the first cleavage onward. The calcium levels began to increase at early...

journal_title：Developmental biology

authors： Kubota HY,Yoshimoto Y,Hiramoto Y

更新日期：1993-12-01 00:00:00

abstract：:The individual blastomeres of the preimplantation mouse embryo become polarized during the 8-cell stage. Microvilli become restricted to the free surface of the embryo and this region of the membrane shows increased labeling with FITC-Con A and trinitrobenzenesulfonate (TNBS). Previous studies have shown that this pol...

journal_title：Developmental biology

authors： Adler RR,Ziomek CA

更新日期：1986-04-01 00:00:00

abstract：:Somatic embryogenesis is one of the best examples of the remarkable developmental plasticity of plants, in which committed somatic cells can dedifferentiate and acquire the ability to form an embryo and regenerate an entire plant. In Arabidopsis thaliana, the shoot apices of young seedlings have been reported as an al...

journal_title：Developmental biology

authors： Kadokura S,Sugimoto K,Tarr P,Suzuki T,Matsunaga S

更新日期：2018-10-01 00:00:00

abstract：:Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

journal_title：Developmental biology

authors： Mason-Suares H,Tie F,Yan CM,Harte PJ

更新日期：2013-08-01 00:00:00

abstract：:Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage oocyte (GV) to a network of distinctive cortical clusters in the metaphase II egg (MII). Multiple lines of evidence suggest that this redis...

journal_title：Developmental biology

authors： FitzHarris G,Marangos P,Carroll J

更新日期：2007-05-01 00:00:00

abstract：:teashirt (tsh) encodes a zinc-finger protein that is thought to be part of a network that contributes to regionalization of the Drosophila embryo and establishes the domains of Hox protein function. tsh and the Hox gene Sex combs reduced (Scr) are essential to establish the identity of the first thoracic segment. We u...

journal_title：Developmental biology

authors： Taghli-Lamallem O,Gallet A,Leroy F,Malapert P,Vola C,Kerridge S,Fasano L

更新日期：2007-07-01 00:00:00

abstract：:DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for...

journal_title：Developmental biology

authors： Shawber C,Boulter J,Lindsell CE,Weinmaster G

更新日期：1996-11-25 00:00:00

abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...

journal_title：Developmental biology

authors： Albertson DG

更新日期：1984-01-01 00:00:00

abstract：:Maintaining tissue homeostasis is a critical process during infection and inflammation. Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid response to infections while simultaneously coordinating cell proliferation and differentiation decisions. In this study, we searched fo...

journal_title：Developmental biology

authors： Zhou J,Florescu S,Boettcher AL,Luo L,Dutta D,Kerr G,Cai Y,Edgar BA,Boutros M

更新日期：2015-03-15 00:00:00

abstract：:RNA localization is tightly coordinated with RNA stability and translation control. Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors are part of a Drosophila transport machinery that localizes mRNAs to specific cellular regions during oogenesis and embryogenesis. We identified the Poly(A)-binding p...

journal_title：Developmental biology

authors： Vazquez-Pianzola P,Urlaub H,Suter B

更新日期：2011-09-15 00:00:00

abstract：:In this paper I sought to determine how the expression of differentiated traits of chick retinal pigmented epithelial (RPE) cells in vitro can be modulated by varying both the biochemical and the spatial complexity, and the mechanical properties, of the growth substratum. I have used glass derivatized with proteins of...

journal_title：Developmental biology

authors： Opas M

更新日期：1989-02-01 00:00:00

abstract：:Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we ana...

journal_title：Developmental biology

authors： Grajales-Esquivel E,Luz-Madrigal A,Bierly J,Haynes T,Reis ES,Han Z,Gutierrez C,McKinney Z,Tzekou A,Lambris JD,Tsonis PA,Del Rio-Tsonis K

更新日期：2017-08-01 00:00:00

abstract：:BMP-2 and BMP-4 are known to be involved in the early events which specify the cardiac lineage. Their later patterns of expression in the developing mouse and chick heart, in the myocardium overlying the atrioventricular canal (AV) and outflow tract (OFT) cushions, also suggest that they may play a role in valvoseptal...

journal_title：Developmental biology

authors： Allen SP,Bogardi JP,Barlow AJ,Mir SA,Qayyum SR,Verbeek FJ,Anderson RH,Francis-West PH,Brown NA,Richardson MK

更新日期：2001-07-01 00:00:00

abstract：:Although a large superfamily of G-protein-coupled receptors serves multiple functions, little is known about their functional activation during ontogeny. To examine the functional activation of the mu-opioid receptor (MOR) and the delta-opioid receptor (DOR) during development, sections of mouse embryos and fetuses fr...

journal_title：Developmental biology

authors： Nitsche JF,Pintar JE

更新日期：2003-01-01 00:00:00