Abstract：
:We present a genetic, developmental and molecular analysis of lethal(1)discs large-1[l(1)d.lg-1; Stewart et al., 1972], an oncogene of Drosophila. Mutations in this gene cause the imaginal discs to grow by cell proliferation beyond their normal final size, transform into solid tumors, fuse with one another and the brain, and lose their ability to differentiate. The oncogene represents the only known complementation group between two deficiency breakpoints, and 15 recessive lethal alleles are available. Cloning of the DNA between the two deficiency breakpoints defines a region of 45 +/- 2 kb. The l(1)d.lg-1 transcription unit is identified by both qualitative and quantitative effects of several l(1)d.lg-1 mutations on the RNA transcripts and by the presence of a DNA insert in one of the l(1)d.lg-1 alleles. It gives rise to at least five different transcripts ranging in size from 1.9 to 6.0 kb. Three other transcription units are present within this region, two 5' to the l(1)d.lg-1 gene and one at the 3' end. A near full-length cDNA from one of the larger transcripts of l(1)d.lg-1 has homology to genomic DNA spanning over 20 kb. A developmental profile of l(1)d.lg-1 transcription is presented. We discuss how mutations in this gene could disrupt epithelial structure and how this might be related to the excessive cell proliferation and interdisc fusion that is observed. We also compare this gene with another recessive oncogene of Drosophila, lethal(2)giant larvae, that has been cloned and characterized.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Woods DF,Bryant PJdoi
10.1016/0012-1606(89)90092-4subject
Has Abstractpub_date
1989-07-01 00:00:00pages
222-35issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(89)90092-4journal_volume
134pub_type
杂志文章abstract：:Chromatin regulators contribute to the developmental control of gene expression. In the nematode Caenorhabditis elegans, the roles of chromatin regulation in development have been explored in several contexts, including vulval differentiation. The synthetic multivulva (synMuv) genes are regulators of vulval developmen...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2014.05.018
更新日期：2014-08-15 00:00:00
abstract：:The germ-line cells of many animals possess a characteristic cytoplasmic structure termed nuage or germinal granules. In mice, nuage that is prominent in postnatal male germ cells is also called intermitochondrial cement or chromatoid bodies. TDRD1/MTR-1, which contains Tudor domain repeats, is a specific component of...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.10.046
更新日期：2007-01-01 00:00:00
abstract：:The expression of the neural cell adhesion molecules N-CAM and L1 was investigated in the olfactory system of the mouse using immunocytochemical and immunochemical techniques. In the olfactory epithelium, globose basal cells and olfactory neurons were stained by the polyclonal N-CAM antibody reacting with all three co...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(88)90397-1
更新日期：1988-10-01 00:00:00
abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1995.8059
更新日期：1995-12-01 00:00:00
abstract：:Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8975
更新日期：1998-11-01 00:00:00
abstract：:Previous experiments have demonstrated that in the septo-hippocampal system choline acetyltransferase (ChAT) is induced by nerve growth factor (NGF) (Gnahn et al. (1983) Dev. Brain Res. 9, 45-52) and that hippocampal NGF and mRNANGF levels are correlated with the density of cholinergic innervation (Korsching et al. (1...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(87)90235-1
更新日期：1987-04-01 00:00:00
abstract：:We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(88)90199-6
更新日期：1988-05-01 00:00:00
abstract：:The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remai...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2017.12.013
更新日期：2018-02-01 00:00:00
abstract：:etv2 is an endothelial-specific ETS transcription factor that is essential for vascular differentiation and morphogenesis in vertebrates. While recent data suggest that Etv2 is dynamically regulated during vascular development, little is known about the mechanisms involved in this process. Here, we find that etv2 tran...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2013.08.028
更新日期：2013-12-01 00:00:00
abstract：:The location, timing and intensity of Nodal signalling are all critical for proper patterning of the vertebrate embryo. Genetic evidence from mouse and zebrafish indicates that EGF-CFC family members are essential for Nodal ligands to signal. However, the Xenopus EGF-CFC, FRL1, has been implicated in Wnt signalling an...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.01.006
更新日期：2006-04-15 00:00:00
abstract：:Mesodermal tissue with heart forming potential (cardiogenic mesoderm) is induced during gastrulation. This cardiogenic mesoderm later differentiates into heart muscle tissue (myocardium) and non-muscular heart tissue. Inhibition of Wnt/beta-catenin signaling is known to be required early for induction of cardiogenic m...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.08.032
更新日期：2008-11-15 00:00:00
abstract：:The specification of the five individual hormone-secreting cell types in the anterior pituitary requires a series of sequential cell fate decisions. We have immortalized cells at several stages along this pathway of pituitary differentiation. Here, we present analysis of differences in gene expression between an anter...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2002.0608
更新日期：2002-04-15 00:00:00
abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2020.09.008
更新日期：2021-01-01 00:00:00
abstract：:During heart formation, the heart grows and undergoes dramatic morphogenesis to achieve efficient embryonic function. Both in fish and amniotes, much of the growth occurring after initial heart tube formation arises from second heart field (SHF)-derived progenitor cell addition to the arterial pole, allowing chamber f...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2020.11.008
更新日期：2021-02-01 00:00:00
abstract：:The segmental origin and migratory pattern of neural crest cells at the trunk level of avian embryos was studied, with special emphasis on the formation of the dorsal root ganglia (DRG) which organize in the anterior half of each somite. Neural crest cells were visualized using the quail-chick marker and HNK-1 immunof...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(87)90236-3
更新日期：1987-04-01 00:00:00
abstract：:Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1997.8619
更新日期：1997-08-01 00:00:00
abstract：:The lateral line system displays highly divergent patterns in adult teleost fish. The mechanisms underlying this variability are poorly understood. Here, we demonstrate that the lateral line mechanoreceptor, the neuromast, gives rise to a series of accessory neuromasts by a serial budding process during postembryonic ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2010.02.017
更新日期：2010-04-15 00:00:00
abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8945
更新日期：1998-08-01 00:00:00
abstract：:Cell division is arguably the most fundamental developmental process for single-celled and multicellular organisms alike. The pathway from one cell division to the next is known as the cell cycle. A conserved biochemical regulatory network controls progress along this pathway in plants, animals, and yeasts. This revie...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/0012-1606(92)90087-w
更新日期：1992-09-01 00:00:00
abstract：:The expression of heat shock genes is induced in all living cells by a series of proteotoxic treatments. Heat shock genes are also activated spontaneously during different phases of embryonic development. HSP89 alpha and HSC70 are expressed at a high level in the mouse blastocyst. A family of factors, called HSFs, are...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1361
更新日期：1994-12-01 00:00:00
abstract：:To examine whether the extracellular matrix (ECM) plays a role in mediating interactions between the apical ectodermal ridge (AER) and the subjacent mesoderm in the chick wing bud, we used immunohistochemistry to locate the following tissue components during wing morphogenesis: types I and IV collagens, fibronectin, t...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1141
更新日期：1994-05-01 00:00:00
abstract：:Embryonic morphogenesis relies on the intrinsic ability of cells, often through remodeling the cytoskeleton, to shape epithelial tissues during development. Epithelial invagination is an example of morphogenesis that depends on this remodeling but the cellular mechanisms driving arrangement of cytoskeletal elements ne...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2020.02.014
更新日期：2020-06-01 00:00:00
abstract：:Little is known about the biochemical changes underlying the morphological differentiation of the sea urchin egg during oogenesis. Because of this and the essential role of gamete recognition in fertilization, we studied the developmental expression of the recently identified egg surface receptor for sperm during ooge...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1233
更新日期：1994-09-01 00:00:00
abstract：:Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2013.01.019
更新日期：2013-05-01 00:00:00
abstract：:The vertebrate liver and heart arise from adjacent cell layers in the anterior lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and heart development are interrelated through reciprocal tissue interactions. Although classical embryological studies performed several decades ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.01.019
更新日期：2004-04-15 00:00:00
abstract：:We have identified cDNA clones encoding a testis-specific poly(A) polymerase, termed TPAP, a candidate molecule responsible for cytoplasmic polyadenylation of preexisting mRNAs in male haploid germ cells. The TPAP gene was most abundantly expressed coincident with the additional elongation of mRNA poly(A) tails in rou...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.9894
更新日期：2000-12-01 00:00:00
abstract：:Understanding the regulatory circuitry controlling myogenesis is critical to understanding developmental mechanisms and developmentally-derived diseases. We analyzed the transcriptional regulation of a Drosophila myogenic repressor gene, Holes in muscles (Him). Previously, Him was shown to inhibit Myocyte enhancer fac...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2015.02.005
更新日期：2015-04-15 00:00:00
abstract：:Similar amounts of expression of a luciferase reporter gene that is driven by the SV40 early promoter are detected in G2 of 1-cell mouse embryo following injection of the male pronucleus in either early or mid/late S. No luciferase activity is observed when the male pronucleus is injected in early S and the embryos an...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1993.1101
更新日期：1993-04-01 00:00:00
abstract：:Developmental boundaries ensure that cells fated to participate in a particular structure are brought together or maintained at the appropriate locale within developing embryos. Parasegment grooves mark the position of boundaries that separate every segment of the Drosophila embryo into anterior and posterior compartm...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2008.04.026
更新日期：2008-09-15 00:00:00
abstract：:Anuran amphibian embryos (Xenopus laevis and Rana dybowskii) are sensitive to novel gravitational fields. Under simulated weightlessness, (i) the location of the first horizontal cleavage furrow was shifted toward the vegetal pole at the eight-cell stage; (ii) the position of the blastocoel was more centered, and the ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1993.1024
更新日期：1993-01-01 00:00:00
