当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.

Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice.

Abstract：

:The germ-line cells of many animals possess a characteristic cytoplasmic structure termed nuage or germinal granules. In mice, nuage that is prominent in postnatal male germ cells is also called intermitochondrial cement or chromatoid bodies. TDRD1/MTR-1, which contains Tudor domain repeats, is a specific component of the mouse nuage, analogously to Drosophila Tudor, a constituent of polar granules/nuage in oocytes and embryos. We show that TDRD6 and TDRD7/TRAP, which also contain multiple Tudor domains, specifically localize to nuage and form a ribonucleoprotein complex together with TDRD1/MTR-1. The characteristic co-localization of TDRD1, 6 and 7 was disrupted in a mutant of mouse vasa homologue/DEAD box polypeptide 4 (Mvh/Ddx4), which encodes another evolutionarily conserved component of nuage. In vivo over-expression experiments of the TDRD proteins and truncated forms during male germ cell differentiation showed that a single Tudor domain is a structural unit that localizes or accumulates to nuage, but the expression of the truncated, putative dominant negative forms is detrimental to meiotic spermatocytes. These results indicate that the Tudor-related proteins, which contain multiple repeats of the Tudor domain, constitute an evolutionarily conserved class of nuage components in the germ-line, and their localization or accumulation to nuage is likely conferred by a Tudor domain structure and downstream of Mvh, while the characteristic repeated architecture of the domain is functionally essential for the differentiation of germ cells.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Hosokawa M,Shoji M,Kitamura K,Tanaka T,Noce T,Chuma S,Nakatsuji N

doi

10.1016/j.ydbio.2006.10.046

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

38-52

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(06)01340-6

journal_volume

301

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

    abstract：:Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.10.020

    authors： Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

    更新日期：2007-01-15 00:00:00

  • Growing dictyate oocytes, but not early preimplantation embryos, of the mouse display high levels of DNA homologous recombination by single-strand annealing and lack DNA nonhomologous end joining.

    abstract：:We have investigated the ability of growing dictyate oocytes and early preimplantation embryos of the mouse to process extrachromosomal DNA molecules with free ends by intranuclearly microinjecting DNA fragments containing a region of homology of various extent at either the 5' or 3' terminus. Homologous recombination...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0199

    authors： Fiorenza MT,Bevilacqua A,Bevilacqua S,Mangia F

    更新日期：2001-05-01 00:00:00

  • Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17.

    abstract：:The Caenorhabditis elegans EGL-17/FGF protein is involved in the gonadal signaling that guides the migrations of sex myoblasts (SMs). egl-17::GFP reporter constructs are expressed dynamically in vulval cell lineages. Expression in the primary vulval cells is correlated with the precise positioning of SMs. We have inve...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00033-2

    authors： Cui M,Han M

    更新日期：2003-05-01 00:00:00

  • Drosophila eye size is determined by Innexin 2-dependent Decapentaplegic signalling.

    abstract：:Organogenesis relies on specific genetic and molecular programmes, which orchestrate growth and cellular differentiation over developmental time. This is particularly important during Drosophila eye development in which cell-cell inductive events and long-range signalling have to be integrated to regulate proper cell ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.10.011

    authors： Richard M,Hoch M

    更新日期：2015-12-01 00:00:00

  • Protein tyrosine kinase activity following fertilization is required to complete gastrulation, but not for initial differentiation of endoderm and mesoderm in the sea urchin embryo.

    abstract：:The egg activation process functions to implement developmental programs that act much later in embryogenesis. One example of this is the fact that application of protein tyrosine kinase inhibitors to the fertilized sea urchin egg for a 15-min period results in a defect in the gastrulation process occurring over 24 h ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8743

    authors： Livingston BT,VanWinkle CE,Kinsey WH

    更新日期：1998-01-01 00:00:00

  • The pattern of cytokeratin synthesis is a marker of type 2 cell differentiation in adult and maturing fetal lung alveolar cells.

    abstract：:During the last stages of fetal life, the immature epithelial cells of the rat lung alveolus develop the properties of mature type 2 cells. Adult type 2 cells rapidly lose these same properties when isolated and maintained in cell culture. We have examined the synthesis of cytokeratin proteins by adult type 2 cells as...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90396-x

    authors： Paine R,Ben-Ze'ev A,Farmer SR,Brody JS

    更新日期：1988-10-01 00:00:00

  • Evidence for the existence of at least two timing mechanisms that contribute to oligodendrocyte generation in vitro.

    abstract：:We have been studying oligodendrocyte generation in vitro to obtain insights into how the timely generation of these cells might be regulated. Our studies suggest the existence of timing mechanisms quite different from those of existing models, wherein it is proposed that timely oligodendrocyte generation is associate...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0280

    authors： Ibarrola N,Mayer-Pröschel M,Rodriguez-Peña A,Noble M

    更新日期：1996-11-25 00:00:00

  • Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.

    abstract：:In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.07.017

    authors： Crish J,Conti MA,Sakai T,Adelstein RS,Egelhoff TT

    更新日期：2013-10-01 00:00:00

  • The sperm surface localization of the TRP-3/SPE-41 Ca2+ -permeable channel depends on SPE-38 function in Caenorhabditis elegans.

    abstract：:Despite undergoing normal development and acquiring normal morphology and motility, mutations in spe-38 or trp-3/spe-41 cause identical phenotypes in Caenorhabditis elegans-mutant sperm fail to fertilize oocytes despite direct contact. SPE-38 is a novel, four-pass transmembrane protein and TRP-3/SPE-41 is a Ca(2+)-per...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.02.037

    authors： Singaravelu G,Chatterjee I,Rahimi S,Druzhinina MK,Kang L,Xu XZ,Singson A

    更新日期：2012-05-15 00:00:00

  • APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

    abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0486

    authors： Levitan D,Yu G,St George Hyslop P,Goutte C

    更新日期：2001-12-15 00:00:00

  • Translation of maternal histone mRNAs in sea urchin embryos: a test of control by 5' cap methylation.

    abstract：:Recent results have demonstrated the occurrence of mRNA cap methylation in the sea urchin embryo following fertilization. It has been suggested that this methylation event is responsible for the translational activation of maternal histone mRNAs in these embryos. We have used aphidicolin, an effective inhibitor of bot...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90161-8

    authors： Showman RM,Leaf DS,Anstrom JA,Raff RA

    更新日期：1987-05-01 00:00:00

  • Separate elements in the 3' untranslated region of the mouse protamine 1 mRNA regulate translational repression and activation during murine spermatogenesis.

    abstract：:The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8705

    authors： Fajardo MA,Haugen HS,Clegg CH,Braun RE

    更新日期：1997-11-01 00:00:00

  • Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

    abstract：:To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9975

    authors： Lupu F,Terwilliger JD,Lee K,Segre GV,Efstratiadis A

    更新日期：2001-01-01 00:00:00

  • Functional equivalence and rescue among group 11 Hox gene products in vertebral patterning.

    abstract：:Hoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene int...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0137

    authors： Zákány J,Gérard M,Favier B,Potter SS,Duboule D

    更新日期：1996-06-15 00:00:00

  • Teloplasm formation in a leech, Helobdella triserialis, is a microtubule-dependent process.

    abstract：:Fertilized eggs of the leech Helobdella triserialis undergo a cytoplasmic reorganization which generates domains of nonyolky cytoplasm, called teloplasm, at the animal and vegetal poles. The segregation of teloplasm to one cell of the eight-cell embryo is responsible for a unique developmental fate of that cell, i.e.,...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90181-4

    authors： Astrow SH,Holton B,Weisblat DA

    更新日期：1989-10-01 00:00:00

  • A role for GATA-6 in vertebrate chondrogenesis.

    abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.12.001

    authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

    更新日期：2008-02-15 00:00:00

  • Developmental activation of the capability to undergo checkpoint-induced apoptosis in the early zebrafish embryo.

    abstract：:In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9243

    authors： Ikegami R,Hunter P,Yager TD

    更新日期：1999-05-15 00:00:00

  • The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

    abstract：:Initiation of the development of the anterior-posterior axis in the mouse embryo has been thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetric migration. However, expression of Lefty1, a marker of the AVE, was recently found to initiate before embryo implantation. This...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.06.020

    authors： Torres-Padilla ME,Richardson L,Kolasinska P,Meilhac SM,Luetke-Eversloh MV,Zernicka-Goetz M

    更新日期：2007-09-01 00:00:00

  • Apoptosis in the neuronal lineage of the mouse olfactory epithelium: regulation in vivo and in vitro.

    abstract：:The olfactory epithelium (OE) of the mouse provides a unique system for understanding how cell birth and cell death interact to regulate neuron number during development and regeneration. We have examined cell death in the OE in normal adult mice; in adult mice subjected to unilateral olfactory bulbectomy (surgical re...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.0025

    authors： Holcomb JD,Mumm JS,Calof AL

    更新日期：1995-11-01 00:00:00

  • Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.

    abstract：:Wnt-4, a member of the Wnt family of secreted signaling molecules, is essential for nephrogenesis, but its expression in the presumptive medulla suggests additional developmental roles in kidney organogenesis. We demonstrate here that Wnt-4 signaling plays also a role in the determination of the fate of smooth muscle ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.02.019

    authors： Itäranta P,Chi L,Seppänen T,Niku M,Tuukkanen J,Peltoketo H,Vainio S

    更新日期：2006-05-15 00:00:00

  • Evidence that protein kinase C (PKC) participates in the meiosis I to meiosis II transition in mouse oocytes.

    abstract：:Oocytes from LTXBO mice exhibit a delayed entry into anaphase I and frequently enter interphase after the first meiotic division. This unique oocyte model was used to test the hypothesis that protein kinase C (PKC) may regulate the meiosis I-to-meiosis II transition. PKC activity was detected in LTXBO oocytes at proph...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0311

    authors： Viveiros MM,Hirao Y,Eppig JJ

    更新日期：2001-07-15 00:00:00

  • Late extraembryonic morphogenesis and its zen(RNAi)-induced failure in the milkweed bug Oncopeltus fasciatus.

    abstract：:Many insects undergo katatrepsis, essential reorganization by the extraembryonic membranes that repositions the embryo. Knockdown of the zen gene by RNA interference (RNAi) prevents katatrepsis in the milkweed bug Oncopeltus fasciatus. However, the precise morphogenetic defect has been uncertain, and katatrepsis itsel...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.06.036

    authors： Panfilio KA

    更新日期：2009-09-15 00:00:00

  • Integration of vascular systems between the brain and spinal cord in zebrafish.

    abstract：:Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of cranial and truncal vascular for...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.07.015

    authors： Kimura E,Isogai S,Hitomi J

    更新日期：2015-10-01 00:00:00

  • Growth cone interactions with a glial cell line from embryonic Xenopus retina.

    abstract：:We have isolated a nonneuronal cell line from Xenopus retinal neuroepithelium (XR1 cell line). On the basis of immunocytochemical characterization using monoclonal antibodies generated in our laboratory as well as several other glial-specific antibodies, we have established that the XR1 cells are derived from embryoni...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90086-9

    authors： Sakaguchi DS,Moeller JF,Coffman CR,Gallenson N,Harris WA

    更新日期：1989-07-01 00:00:00

  • The nieuwkoid/dharma homeobox gene is essential for bmp2b repression in the zebrafish pregastrula.

    abstract：:Dorsoventral specification of the zebrafish gastrula is governed by the functions of the dorsal shield, a region of the embryo functionally analogous to the amphibian Spemann organizer. We report that the bozozok locus encodes the transcription factor nieuwkoid/dharma, a homeobox gene with non-cell-autonomous organize...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9479

    authors： Koos DS,Ho RK

    更新日期：1999-11-15 00:00:00

  • Involvement of K(Ca) channels and stretch-activated channels in calcium influx, triggering membrane fusion of chick embryonic myoblasts.

    abstract：:Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0091

    authors： Shin KS,Park JY,Ha DB,Chung CH,Kang MS

    更新日期：1996-04-10 00:00:00

  • Changing of the cell division axes drives vulva evolution in nematodes.

    abstract：:Vulval epithelial tubes invaginate through concerted cell migration, ring formation, stacking of rings and intra-ring cell fusion in the nematodes Caenorhabditis elegans, Oscheius tipulae and Pristionchus pacificus. The number of rings forming the invaginations is invariantly seven, six, and eight, respectively. We hy...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.10.010

    authors： Kolotuev I,Podbilewicz B

    更新日期：2008-01-01 00:00:00

  • Molecular mechanism of mammary gland involution: An update.

    abstract：:The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.11.002

    authors： Jena MK,Jaswal S,Kumar S,Mohanty AK

    更新日期：2019-01-15 00:00:00

  • Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.

    abstract：:The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.10.023

    authors： Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

    更新日期：2009-01-01 00:00:00

  • Identification of DNA-binding protein(s) in the developing heart.

    abstract：:An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1088

    authors： Litvin J,Montgomery MO,Goldhamer DJ,Emerson CP Jr,Bader DM

    更新日期：1993-04-01 00:00:00