A role for GATA-6 in vertebrate chondrogenesis.


:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal development but we now identify a possible role for GATA-6 in chondrogenesis. We detect abundant levels of GATA-6 mRNA in precartilaginous condensations (PCCs) in both the axial and appendicular skeleton of mouse embryos and in committed primary chondrocyte precursors. We also show that the G-protein coupled receptor, Gpr49, is a target of GATA-6 regulation in differentiating embryonal carcinoma cells and that, in vivo, the expression domains of the two genes overlap within PCCs. Finally, we have identified conserved, canonical GATA binding sites within the Gpr49 gene locus, and show by EMSAs that GATA-6 can bind to these sites in vitro. These data therefore suggest that GATA-6 also plays a role in chondrogenesis and that Gpr49 is a potential direct target of GATA regulation in this process.


Dev Biol


Developmental biology


Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA




Has Abstract


2008-02-15 00:00:00














  • The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil.

    abstract::The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sprecher SG,Cardona A,Hartenstein V

    更新日期:2011-10-01 00:00:00

  • CLIP-50 immunolocalization during mouse spermiogenesis suggests a role in shaping the sperm nucleus.

    abstract::The spermatid nucleus and cytoplasm undergo dramatic morphological modifications during spermatid differentiation into mature sperm. Some of the external force causing this nuclear shaping is generated by a microtubular structure termed the manchette, which attaches to the perinuclear ring of the spermatid. Here, we r...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tarsounas M,Pearlman RE,Moens PB

    更新日期:2001-08-15 00:00:00

  • Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis.

    abstract::The members of the transforming growth factor-beta (TGF-beta) superfamily are secreted proteins that interact with cell-surface receptors to elicit signals that regulate a variety of biological processes during vertebrate embryogenesis. Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family rece...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Mishina Y,Crombie R,Bradley A,Behringer RR

    更新日期:1999-09-15 00:00:00

  • Coexpression of embryonic, fetal, and adult globins in erythroid cells of human embryos: relevance to the cell-lineage models of globin switching.

    abstract::The cellular control of the switch from embryonic to fetal globin formation in man was investigated with studies of globin expression in erythroid cells of 35- to 56-day-old embryos. Analyses of globins synthesized in vivo and in cultures of erythroid progenitors (burst-forming units, BFUe) showed that cells of the yo...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Stamatoyannopoulos G,Constantoulakis P,Brice M,Kurachi S,Papayannopoulou T

    更新日期:1987-09-01 00:00:00

  • Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues.

    abstract::In the Drosophila ventral nerve cord, the three pairs of Capability neuropeptide-expressing Va neurons are exclusively found in the second, third and fourth abdominal segments (A2-A4). To address the underlying mechanisms behind such segment-specific cell specification, we followed the developmental specification of t...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Suska A,Miguel-Aliaga I,Thor S

    更新日期:2011-05-01 00:00:00

  • Transient catecholaminergic (TC) cells in the vagus nerves and bowel of fetal mice: relationship to the development of enteric neurons.

    abstract::Catecholaminergic cells are transiently present during development of the fetal murine bowel. These transient catecholaminergic (TC) cells appear at Day E10, but by Day E13 can no longer be detected. In order to evaluate the hypothesis that these cells are the precursors of enteric neurons, we investigated the possibi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Baetge G,Gershon MD

    更新日期:1989-03-01 00:00:00

  • sem-4/spalt and egl-17/FGF have a conserved role in sex myoblast specification and migration in P. pacificus and C. elegans.

    abstract::Evolutionary comparisons between Caenorhabditis elegans and the satellite organism Pristionchus pacificus revealed major differences in the regulation of nematode vulva development. For example, Wnt signaling is part of a negative signaling system that prevents vulva formation in P. pacificus, whereas it plays a posit...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Photos A,Gutierrez A,Sommer RJ

    更新日期:2006-05-01 00:00:00

  • Sperm-induced Ca(2+) oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: evidence to support a continuous low level production of inositol 1, 4,5-trisphosphate during mammalian fertilization.

    abstract::During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Jones KT,Nixon VL

    更新日期:2000-09-01 00:00:00

  • Late extraembryonic morphogenesis and its zen(RNAi)-induced failure in the milkweed bug Oncopeltus fasciatus.

    abstract::Many insects undergo katatrepsis, essential reorganization by the extraembryonic membranes that repositions the embryo. Knockdown of the zen gene by RNA interference (RNAi) prevents katatrepsis in the milkweed bug Oncopeltus fasciatus. However, the precise morphogenetic defect has been uncertain, and katatrepsis itsel...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Panfilio KA

    更新日期:2009-09-15 00:00:00

  • The receptor phosphatase HmLAR2 collaborates with focal adhesion proteins in filopodial tips to control growth cone morphology.

    abstract::Receptor protein tyrosine phosphatases (RPTPs) have been shown to play key roles in regulating axon guidance and synaptogenesis. HmLAR2, one of two closely related LAR-like RPTPs in the embryonic leech, is expressed in a few central neurons and in a unique segmentally-iterated peripheral cell, the comb cell (CC). Here...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Baker MW,Peterson SM,Macagno ER

    更新日期:2008-08-01 00:00:00

  • Distinct neural stem cells proliferate in response to EGF and FGF in the developing mouse telencephalon.

    abstract::Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tropepe V,Sibilia M,Ciruna BG,Rossant J,Wagner EF,van der Kooy D

    更新日期:1999-04-01 00:00:00

  • BMP7 inhibits branching morphogenesis in the prostate gland and interferes with Notch signaling.

    abstract::The mouse prostate gland develops by branching morphogenesis from the urogenital epithelium and mesenchyme. Androgens and developmental factors, including FGF10 and SHH, promote prostate growth (Berman, D.M., Desai, N., Wang, X., Karhadkar, S.S., Reynon, M., Abate-Shen, C., Beachy, P.A., Shen, M.M., 2004. Roles for He...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Grishina IB,Kim SY,Ferrara C,Makarenkova HP,Walden PD

    更新日期:2005-12-15 00:00:00

  • p53-mediated germ cell quality control in spermatogenesis.

    abstract::Spontaneous germ cell death is a common cellular process in the mammalian testis, although the function of this process during spermatogenesis is unclear. An investigation was undertaken to determine whether p53 serves as a mechanism in germ cell quality control by causing spontaneous germ cell death. Using an annexin...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Yin Y,Stahl BC,DeWolf WC,Morgentaler A

    更新日期:1998-12-01 00:00:00

  • Corneal stromal fibroblasts from adult rabbits retain the capacity to deposit an orthogonal matrix.

    abstract::Stromal fibroblasts from the adult rabbit cornea were propagated in vitro, then injected into the vitreous compartment of normal rabbit eyes. In this environment the stromal cells deposited a matrix of imperfect orthogonal collagenous lamellae resembling normal corneal stroma. Extracellular matrices were also secreted...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Burke JM,Foster SJ

    更新日期:1985-03-01 00:00:00

  • Patterning of avian craniofacial muscles.

    abstract::Vertebrate voluntary muscles are composed of myotubes and connective tissue cells. These two cell types have different embryonic origins: myogenic cells arise from paraxial mesoderm, while in the head many of the connective tissues are formed by neural crest cells. The objective of this research was to study interacti...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Noden DM

    更新日期:1986-08-01 00:00:00

  • Evolution of nematode vulval fate patterning.

    abstract::Nematodes provide a useful experimental system with which to investigate the evolution of development at the cellular, genetic, and molecular levels. Building on an understanding of vulval development in Caenorhabditis elegans, analysis of vulval development has been extended to a number of other species in three fami...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Sommer RJ,Sternberg PW

    更新日期:1996-02-01 00:00:00

  • Hox transcription factor Antp regulates sericin-1 gene expression in the terminal differentiated silk gland of Bombyx mori.

    abstract::Hox genes are well-known master regulators in developmental morphogenesis along the anteroposterior axis of animals. However, the molecular mechanisms by which Hox proteins regulate their target genes and determine cell fates are not fully understood. The silk gland of Bombyx mori is a tubular tissue divided into seve...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kimoto M,Tsubota T,Uchino K,Sezutsu H,Takiya S

    更新日期:2014-02-01 00:00:00

  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract::Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

    更新日期:1995-06-01 00:00:00

  • Effects of phlorizin and ouabain on the polarity of mouse 4-cell/16-cell stage blastomere heterokaryons.

    abstract::Cell polarity is thought to be required for the efficient production of nascent blastocoele fluid, which begins at the 16-cell stage of mouse preimplantation development. In this study the 4-cell/16-cell blastomere heterokaryon was used to test the hypothesis that solute transport across the apical membrane domain ind...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wiley LM,Obasaju MF

    更新日期:1989-06-01 00:00:00

  • Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones.

    abstract::Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lukinius A,Ericsson JL,Grimelius L,Korsgren O

    更新日期:1992-10-01 00:00:00

  • Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions.

    abstract::Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expr...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Althoff F,Viktorinová I,Kastl J,Lehner CF

    更新日期:2009-09-15 00:00:00

  • Intracellular calcium release channel expression during embryogenesis.

    abstract::The release of intracellular calcium (Ca2+) via either inositol 1,4, 5-trisphosphate receptors (IP3R) or ryanodine receptors (RyR) activates a wide variety of signaling pathways in virtually every type of cell. In the present study we demonstrate that at early stages of development IP3R mRNA and functional IP3-gated C...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rosemblit N,Moschella MC,Ondriašová E,Gutstein DE,Ondriaš K,Marks AR

    更新日期:1999-02-15 00:00:00

  • Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells.

    abstract::Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9. Although Isl1 expression is downregulated in most cardiac progenitors as the...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sun Y,Liang X,Najafi N,Cass M,Lin L,Cai CL,Chen J,Evans SM

    更新日期:2007-04-01 00:00:00

  • Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo.

    abstract::The segregation of founder cells from the somatic mesoderm is a prerequisite for the formation of body wall muscles in the Drosophila embryo. The myogenic basic helix-loop-helix protein, Nautilus (Nau), is expressed in a subset of these founder cells in medial and lateral positions in the somatic mesoderm. Mutations i...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ranganayakulu G,Schulz RA,Olson EN

    更新日期:1996-05-25 00:00:00

  • Expression pattern of GDNF, c-ret, and GFRalphas suggests novel roles for GDNF ligands during early organogenesis in the chick embryo.

    abstract::We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Homma S,Oppenheim RW,Yaginuma H,Kimura S

    更新日期:2000-01-01 00:00:00

  • An oocyte-specific astacin family protease, alveolin, is released from cortical granules to trigger egg envelope hardening during fertilization in medaka (Oryzias latipes).

    abstract::It has long been hypothesized that in fishes the contents of cortical granules are involved in the hardening of egg envelope following fertilization. We previously purified the egg envelope hardening initiation factor from the exudates released from activated medaka (Oryzias latipes) eggs and tentatively termed this p...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shibata Y,Iwamatsu T,Suzuki N,Young G,Naruse K,Nagahama Y,Yoshikuni M

    更新日期:2012-12-15 00:00:00

  • Defining a large set of full-length clones from a Xenopus tropicalis EST project.

    abstract::Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

    更新日期:2004-07-15 00:00:00

  • Pax6 regulates regional development and neuronal migration in the cerebral cortex.

    abstract::Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of w...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Talamillo A,Quinn JC,Collinson JM,Caric D,Price DJ,West JD,Hill RE

    更新日期:2003-03-01 00:00:00

  • Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis.

    abstract::In many organisms early embryogenesis is characterised by a period refractory to transcription. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. This model suggests that histone tail modifications associated ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wang S,Fisher K,Poulin GB

    更新日期:2011-07-15 00:00:00

  • Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network.

    abstract::In C. elegans the 4-cell stage blastomere EMS is an endomesodermal precursor. Its anterior daughter, MS, makes primarily mesodermal cells, while its posterior daughter E generates the entire intestine. The gene regulatory network underlying specification of MS and E has been the subject of study for more than 15 years...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Owraghi M,Broitman-Maduro G,Luu T,Roberson H,Maduro MF

    更新日期:2010-04-15 00:00:00