Synthesis and distribution of carbohydrate chains in cleavage-stage mouse embryos carrying the t12 lethal mutation.

Abstract:

:Carbohydrate chains on the t12 mutant embryos were analyzed. No abnormalities of the synthesis of the carbohydrate chains were observed in the t12 homozygotes until the late morula stage, when radiolabeled carbohydrate chains were analyzed by Sephadex G-50 column chromatography. Furthermore, polarization of the Con A receptor occurred normally at the eight-cell stage. Therefore, the possible defects of the carbohydrate chains on the t12 embryos were suggested to be neither gross abnormality of the synthesis nor abnormal localization on the surface, but rather minor structural changes on a specific molecule.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Iwakura Y,Nozaki M

doi

10.1016/0012-1606(88)90309-0

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

474-6

issue

2

eissn

0012-1606

issn

1095-564X

pii

0012-1606(88)90309-0

journal_volume

128

pub_type

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