Epicardium is required for cardiac seeding by yolk sac macrophages, precursors of resident macrophages of the adult heart.

Abstract:

:A subset of macrophages that reside in adult tissues originate from the fetal yolk sac, while others derive from circulating monocytes. These ontologically different macrophage subsets have distinct roles in tissue injury responses, with the embryonic population overall having beneficial activity in cardiac repair. Here we show that fetal yolk macrophages are recruited to a niche within and just below the epicardium, the mesothelial covering of the heart. The epicardium was required for establishment of yolk sac macrophages in this region of the fetal heart, and this function of epicardium depended on its expression of the transcription factor WT1. Thus, tissue-specific cues and transcriptional programs recruit or retain embryonic macrophages in their final abodes, where they help to shape organ homeostasis and injury responses.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Stevens SM,von Gise A,VanDusen N,Zhou B,Pu WT

doi

10.1016/j.ydbio.2016.03.014

subject

Has Abstract

pub_date

2016-05-15 00:00:00

pages

153-159

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(15)30155-X

journal_volume

413

pub_type

杂志文章
  • In vitro penetration of hamster oocyte-cumulus complexes using physiological numbers of sperm.

    abstract::We have compared the ability of uncapacitated, capacitated acrosome intact, and acrosome-reacted hamster sperm to penetrate the cumulus and corona radiata of fresh hamster oocyte-cumulus complexes (OCC) in vitro. This was done using physiological numbers (1-20) of sperm so that cumulus and corona radiata cells did not...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90348-4

    authors: Corselli J,Talbot P

    更新日期:1987-07-01 00:00:00

  • Primary mesenchyme cell migration requires a chondroitin sulfate/dermatan sulfate proteoglycan.

    abstract::Primary mesenchyme cell migration in the sea urchin embryo is inhibited by sulfate deprivation and exposure to exogenous beta-D-xylosides, two treatments known to disrupt proteoglycan synthesis. We show that in the developing sea urchin, exogenous xyloside affects the synthesis by the primary mesenchyme cells of a ver...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(91)90089-l

    authors: Lane MC,Solursh M

    更新日期:1991-02-01 00:00:00

  • Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells.

    abstract::A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is governed by cell position-dependent Hippo signaling, which is a phosphorylation ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2020.09.004

    authors: Yamamura S,Goda N,Akizawa H,Kohri N,Balboula AZ,Kobayashi K,Bai H,Takahashi M,Kawahara M

    更新日期:2020-12-01 00:00:00

  • Tube formation by complex cellular processes in Ciona intestinalis notochord.

    abstract::In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.03.015

    authors: Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

    更新日期:2009-06-15 00:00:00

  • Substratum effects on cell dispersal, morphology, and differentiation in cultures of avian neural crest cells.

    abstract::Adhesive extracellular matrix (ECM) molecules appear to play roles in the migration of neural crest cells, and may also provide cues for differentiation of these cells into a variety of phenotypes. We are studying the influences of specific ECM components on crest differentiation at the levels of both individual cells...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(90)90112-v

    authors: Rogers SL,Bernard L,Weston JA

    更新日期:1990-09-01 00:00:00

  • Do as I say, Not(ch) as I do: Lateral control of cell fate.

    abstract::Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell fate, is an essential developmental mechanism. Similarly, domain and boundary establishment are crucial steps to forming organs during development. Notch signaling is a pathway ideally suited to mediating precise patterning cu...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ydbio.2017.09.032

    authors: Sjöqvist M,Andersson ER

    更新日期:2019-03-01 00:00:00

  • Growth regulation of the interstitial cell population in hydra. I. Evidence for global control by nerve cells in the head.

    abstract::The interstitial cells of hydra form a multipotent stem cell system, producing terminally differentiated nerve cells and nematocytes during asexual growth. Under well-fed conditions the interstitial cell population doubles in size every 4 days. We have investigated the possible role of nerve cells in regulating this b...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(85)90089-2

    authors: Heimfeld S,Bode HR

    更新日期:1985-08-01 00:00:00

  • Development and tissue origins of the mammalian cranial base.

    abstract::The vertebrate cranial base is a complex structure composed of bone, cartilage and other connective tissues underlying the brain; it is intimately connected with development of the face and cranial vault. Despite its central importance in craniofacial development, morphogenesis and tissue origins of the cranial base h...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.07.016

    authors: McBratney-Owen B,Iseki S,Bamforth SD,Olsen BR,Morriss-Kay GM

    更新日期:2008-10-01 00:00:00

  • Nerve and muscle development in paralysé mutant mice.

    abstract::Nerve and muscle development was studied in paralysé mutant mice. The mutant phenotype is first recognizable 6-7 days after birth (PN 6-PN 7) as cessation of muscle growth and weakness and incoordination of movement. Mutant animals die between 2 and 3 weeks of age. Muscle fibers from paralysé mutants had a unimodal di...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(89)90213-3

    authors: Blondet B,Duxson MJ,Harris AJ,Melki J,Guénet JL,Pinçon-Raymond M,Rieger F

    更新日期:1989-03-01 00:00:00

  • Mast cells contribute to the stromal microenvironment in mammary gland branching morphogenesis.

    abstract::The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.10.021

    authors: Lilla JN,Werb Z

    更新日期:2010-01-01 00:00:00

  • Abnormal keratinization in the pupoid fetus (pf/pf) mutant mouse epidermis.

    abstract::During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90194-5

    authors: Fisher C,Dale BA,Kollar EJ

    更新日期:1984-04-01 00:00:00

  • Development of inositol trisphosphate-induced calcium release mechanism during maturation of hamster oocytes.

    abstract::Mature hamster eggs exhibit repetitive increases in the intracellular Ca2+ concentration ([Ca2+]i) at fertilization, caused by inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release (IICR) from stores. Oscillating Ca2+ rises also occurred in inseminated immature oocytes at the germinal vesicle (GV) stage but the pe...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1993.1059

    authors: Fujiwara T,Nakada K,Shirakawa H,Miyazaki S

    更新日期:1993-03-01 00:00:00

  • Subcellular trafficking of the nuclear receptor COUP-TF in the early embryonic cell cycle.

    abstract::The nuclear receptor SpCOUP-TF is the highly conserved sea urchin homologue of the COUP family of transcription factors. Previous results from our laboratory demonstrated that SpCOUP-TF transcripts are localized in the egg and asymmetrically distributed in the early embryonic blastomeres (A. Vlahou et al., 1996, Devel...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1999.9456

    authors: Vlahou A,Flytzanis CN

    更新日期:2000-02-15 00:00:00

  • Germline and somatic mosaicism in transgenic mice.

    abstract::Analysis of 262 transgenic mouse pedigrees suggests that about 30% of the mice produced by microinjection of plasmids into pronuclei are mosaic in the germline. This implies that in these lines integration of the foreign DNA occurred after the first round of chromosomal DNA replication. In mosaics resulting from delay...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(86)90068-0

    authors: Wilkie TM,Brinster RL,Palmiter RD

    更新日期:1986-11-01 00:00:00

  • Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo.

    abstract::The segregation of founder cells from the somatic mesoderm is a prerequisite for the formation of body wall muscles in the Drosophila embryo. The myogenic basic helix-loop-helix protein, Nautilus (Nau), is expressed in a subset of these founder cells in medial and lateral positions in the somatic mesoderm. Mutations i...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.9987

    authors: Ranganayakulu G,Schulz RA,Olson EN

    更新日期:1996-05-25 00:00:00

  • The selector genes midline and H15 control ventral leg pattern by both inhibiting Dpp signaling and specifying ventral fate.

    abstract::mid and H15 encode Tbx20 transcription factors that specify ventral pattern in the Drosophila leg. We find that there are at least two pathways for mid and H15 specification of ventral fate. In the first pathway, mid and H15 negatively regulate Dpp, the dorsal signal in leg development. mid and H15 block the dorsalizi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2019.05.012

    authors: Svendsen PC,Phillips LA,Deshwar AR,Ryu JR,Najand N,Brook WJ

    更新日期:2019-11-01 00:00:00

  • Outgrowth by fin motor axons in wildtype and a finless mutant of the Japanese medaka fish.

    abstract::The outgrowth of motor axons to the developing pectoral fin of the Japanese medaka fish (Oryzias latipes) was investigated both in wildtype embryos and in the pectoral finless (pl) mutants in which adults are missing pectoral fins. Late in embryogenesis the pectoral fin is a simple limb which contains two antagonist m...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(91)90445-9

    authors: Okamoto H,Kuwada JY

    更新日期:1991-07-01 00:00:00

  • An ECM-bound, PDGF-like growth factor and a TGF-alpha-like growth factor are required for gastrulation and spiculogenesis in the Lytechinus embryo.

    abstract::Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.8059

    authors: Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

    更新日期:1995-12-01 00:00:00

  • Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis.

    abstract::In many organisms early embryogenesis is characterised by a period refractory to transcription. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. This model suggests that histone tail modifications associated ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.04.010

    authors: Wang S,Fisher K,Poulin GB

    更新日期:2011-07-15 00:00:00

  • Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.

    abstract::The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.08.041

    authors: Ozil JP,Banrezes B,Tóth S,Pan H,Schultz RM

    更新日期:2006-12-15 00:00:00

  • DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells.

    abstract::Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested t...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.06.013

    authors: Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl M

    更新日期:2008-09-01 00:00:00

  • Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.

    abstract::Hand proteins are evolutionally conserved basic helix-loop-helix (bHLH) transcription factors implicated in development of neural crest-derived tissues, heart and limb. Hand1 is expressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain extends ventrolaterally to occupy two-thi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.07.036

    authors: Barbosa AC,Funato N,Chapman S,McKee MD,Richardson JA,Olson EN,Yanagisawa H

    更新日期:2007-10-01 00:00:00

  • The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye.

    abstract::Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1999.9314

    authors: Kidson SH,Kume T,Deng K,Winfrey V,Hogan BL

    更新日期:1999-07-15 00:00:00

  • Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells.

    abstract::Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.03.040

    authors: Hemberger M,Hughes M,Cross JC

    更新日期:2004-07-15 00:00:00

  • Na/K-ATPase-mediated 86Rb+ uptake and asymmetrical trophectoderm localization of alpha1 and alpha3 Na/K-ATPase isoforms during bovine preattachment development.

    abstract::This study evaluated Na/K-ATPase alpha 1- and alpha 3-subunit isoform polypeptide expression and localization during bovine preattachment development. Na/K-ATPase cation transport activity from the one-cell to blastocyst stage was also determined by measuring ouabain-sensitive 86Rb+ uptake. Both alpha1- and alpha 3-su...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1998.8874

    authors: Betts DH,Barcroft LC,Watson AJ

    更新日期:1998-05-01 00:00:00

  • Control of nerve cord formation by Engrailed and Gooseberry-Neuro: A multi-step, coordinated process.

    abstract::One way to better understand the molecular mechanisms involved in the construction of a nervous system is to identify the downstream effectors of major regulatory proteins. We previously showed that Engrailed (EN) and Gooseberry-Neuro (GsbN) transcription factors act in partnership to drive the formation of posterior ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2017.10.018

    authors: Bonneaud N,Layalle S,Colomb S,Jourdan C,Ghysen A,Severac D,Dantec C,Nègre N,Maschat F

    更新日期:2017-12-15 00:00:00

  • Formation and function of the polar body contractile ring in Spisula.

    abstract::Initial studies suggested that spatial organization of the putative polar body contractile ring was determined by the peripheral aster in Spisula [Biol. Bull. 205 (2003) 192]. Here we report detailed supporting observations, including testing of aster and ring function with inhibitors. The metaphase peripheral aster w...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.01.033

    authors: Pielak RM,Gaysinskaya VA,Cohen WD

    更新日期:2004-05-15 00:00:00

  • Regulation of broad by the Notch pathway affects timing of follicle cell development.

    abstract::During Drosophila oogenesis, activation of Notch signaling in the follicular epithelium (FE) around stage 6 of oogenesis is essential for entry into the endocycle and a series of other changes such as cell differentiation and migration of subsets of the follicle cells. Notch induces the expression of zinc finger prote...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.04.024

    authors: Jia D,Tamori Y,Pyrowolakis G,Deng WM

    更新日期:2014-08-01 00:00:00

  • Cell degeneration in the developing optic lobes of the sine oculis and small-optic-lobes mutants of Drosophila melanogaster.

    abstract::In the small-optic-lobes (sol) and sine oculis (so) mutants of Drosophila melanogaster extensive cell death occurs in the optic lobes during the first half of pupal development. Gynandromorph flies show that the sol mutation acts primarily on cells of the medulla cortex. Degeneration of medullar ganglion cells occurs ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90050-2

    authors: Fischbach KF,Technau G

    更新日期:1984-07-01 00:00:00

  • An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes.

    abstract::Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1999.9524

    authors: Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

    更新日期:1999-12-15 00:00:00