当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > The Drosophila IMP-E2 gene encodes an apically secreted protein expressed during imaginal disc morphogenesis.

The Drosophila IMP-E2 gene encodes an apically secreted protein expressed during imaginal disc morphogenesis.

Abstract：

:During metamorphosis, the steroid hormone 20-hydroxyecdysone induces morphogenesis of imaginal discs, including the formation of appendages. IMP-E2 is an ecdysone-dependent, single-copy Drosophila gene, whose transcripts accumulate rapidly in imaginal discs in response to the hormone. The IMP-E2 product is secreted at the apical surface of the disc epithelium in association with disc morphogenesis. The product is also secreted apically by the embryonic ectoderm during mid embryogenesis. The deduced primary structure of the protein reveals the presence of 16, short 3-amino acid repeat motifs (such as EIK and EVK) toward the N-terminal end of the protein, and three long, uncharged domains, containing 43 to 78 residues each, toward the C-terminal end. The predicted structure of the protein suggests that it may participate in multimolecular aggregates. Although the temporal and spatial expression of the IMP-E2 gene are consistent with a role in disc morphogenesis, its specific functions remain to be determined.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Paine-Saunders S,Fristrom D,Fristrom JW

doi

10.1016/0012-1606(90)90084-v

subject

Has Abstract

pub_date

1990-08-01 00:00:00

pages

337-51

issue

2

eissn

0012-1606

issn

1095-564X

pii

0012-1606(90)90084-V

journal_volume

140

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Adhesive but not signaling activity of Drosophila N-cadherin is essential for target selection of photoreceptor afferents.

    abstract：:Drosophila N-cadherin (CadN) is an evolutionarily conserved, atypical classical cadherin, which has a large complex extracellular domain and a catenin-binding cytoplasmic domain. We have previously shown that CadN regulates target selection of R7 photoreceptor axons. To determine the functional domains of CadN, we con...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.01.030

    authors： Yonekura S,Xu L,Ting CY,Lee CH

    更新日期：2007-04-15 00:00:00

  • Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system.

    abstract：:Neuropilin (previously known as the A5 protein) is a membrane protein identified in Xenopus and is presumed to be involved in the target recognition of the optic nerve fibers. We have isolated cDNAs encoding the chick homologue of neuropilin, using the Xenopus neuropilin cDNA as a hybridization probe. The predicted am...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1208

    authors： Takagi S,Kasuya Y,Shimizu M,Matsuura T,Tsuboi M,Kawakami A,Fujisawa H

    更新日期：1995-07-01 00:00:00

  • The alphaBbetaC integrin is expressed on the surface of the sea urchin egg and removed at fertilization.

    abstract：:Integrins are expressed on the surface of some vertebrate eggs where they are thought to have a role in fertilization. The objective of this study is to determine if integrins are expressed on sea urchin eggs. The alphaB and betaC subunits were cloned using the homology polymerase chain reaction. Monoclonal and polycl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9910

    authors： Murray G,Reed C,Marsden M,Rise M,Wang D,Burke RD

    更新日期：2000-11-15 00:00:00

  • prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish.

    abstract：:Segmentation is a key step in embryonic development. Acting in all germ layers, it is responsible for the generation of antero-posterior asymmetries. Hox genes, with their diverse expression in individual segments, are fundamental players in the determination of different segmental fates. In vertebrates, Hox gene prod...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.04.016

    authors： Vaccari E,Deflorian G,Bernardi E,Pauls S,Tiso N,Bortolussi M,Argenton F

    更新日期：2010-07-01 00:00:00

  • Apoptosis regulates notochord development in Xenopus.

    abstract：:The notochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling center and as the primitive skeleton. In this study we show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.08.047

    authors： Malikova MA,Van Stry M,Symes K

    更新日期：2007-11-15 00:00:00

  • Manipulation of medium conditions and differentiation in the rat myogenic cell line L6.

    abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90192-1

    authors： Pinset C,Whalen RG

    更新日期：1984-04-01 00:00:00

  • Dynamics of germ plasm localization and its inhibition by ultraviolet irradiation in early cleavage Xenopus embryos.

    abstract：:In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1142

    authors： Savage RM,Danilchik MV

    更新日期：1993-06-01 00:00:00

  • C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.

    abstract：:The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.12.005

    authors： Inoue T,Sternberg PW

    更新日期：2010-02-15 00:00:00

  • Analysis of gene expression in rapidly developing mutants of Dictyostelium discoideum.

    abstract：:Developmentally regulated gene expression has been analyzed in the wild-type D. discoideum strain NC-4 and a series of temporally deranged mutants. The mutants include representatives from each class of rapid development mutation, Fr17(rdeA-) and HT506(rdeC-), and strain HIfm-1, which appears to be defective in the ti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90260-5

    authors： Saxe CL 3rd,Firtel RA

    更新日期：1986-06-01 00:00:00

  • The coupling of cyclic GMP and photopolarization of Pelvetia zygotes.

    abstract：:Unidirectional blue light directs the rhizoid-thallus axis in the apolar zygotes of Fucus and Pelvetia. Here, it is shown that blue light (but not red light) increased cyclic GMP levels of Pelvetia zygotes by about a factor of 2. When the increase in cyclic GMP was blocked by a guanylyl cyclase inhibitor, photopolariz...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8600

    authors： Robinson KR,Miller BJ

    更新日期：1997-07-01 00:00:00

  • Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.

    abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.05.001

    authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

    更新日期：2016-07-01 00:00:00

  • Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest.

    abstract：:Pigment cells of the zebrafish, Danio rerio, offer an exceptionally tractable system for studying the genetic and cellular bases of cell fate decisions. In the zebrafish, neural crest cells generate three types of pigment cells during embryogenesis: yellow xanthophores, iridescent iridophores and black melanophores. I...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.04.023

    authors： Curran K,Lister JA,Kunkel GR,Prendergast A,Parichy DM,Raible DW

    更新日期：2010-08-01 00:00:00

  • Requirement for Mab21l2 during development of murine retina and ventral body wall.

    abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.07.016

    authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

    更新日期：2004-10-15 00:00:00

  • Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature.

    abstract：:Chicken talpid(3) mutant embryos have a wide range of Hedgehog-signalling related defects and it is now known that the talpid(3) gene product encodes a novel protein essential for Hedgehog signalling which is required for both activator and repressor functions of Gli transcription factors (Davey, M.G., Paton, I.R., Yi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.08.017

    authors： Davey MG,James J,Paton IR,Burt DW,Tickle C

    更新日期：2007-01-01 00:00:00

  • Modulation of N-cadherin junctions and their role as epicenters of differentiation-specific actin regulation in the developing lens.

    abstract：:Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.10.009

    authors： Leonard M,Zhang L,Zhai N,Cader A,Chan Y,Nowak RB,Fowler VM,Menko AS

    更新日期：2011-01-15 00:00:00

  • Transcription factor NFY globally represses the expression of the C. elegans Hox gene Abdominal-B homolog egl-5.

    abstract：:The C. elegans Hox gene egl-5 (ortholog of Drosophila Abdominal-B) is expressed in multiple tissues in the tail region and is involved in tail patterning. In this study, we identify and clone the corresponding C. elegans orthologs of the components of the heterotrimeric transcription factor NFY, nfya-1, nfyb-1 and nfy...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.05.021

    authors： Deng H,Sun Y,Zhang Y,Luo X,Hou W,Yan L,Chen Y,Tian E,Han J,Zhang H

    更新日期：2007-08-15 00:00:00

  • Widespread tangential dispersion and extensive cell death during early neurogenesis in the mouse neocortex.

    abstract：:The development of the mammalian neocortex requires radial and tangential migration of cells. Radial migration of differentiated neurons from the ventricular zone (VZ) is well established. It is hypothesised that an earlier phase of tangential migration of mitotically active cells lays down a widespread periodically s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.11.006

    authors： Wilkie AL,Jordan SA,Sharpe JA,Price DJ,Jackson IJ

    更新日期：2004-03-01 00:00:00

  • Id4 is required for the correct timing of neural differentiation.

    abstract：:Complex intrinsic and extrinsic mechanisms determine neural cell fate during development of the nervous system. Using Id4 deficient mice, we show that Id4 is required for normal development of the central nervous system (CNS), timing neural differentiation in the developing forebrain. In the absence of Id4, the ventri...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.02.001

    authors： Bedford L,Walker R,Kondo T,van Crüchten I,King ER,Sablitzky F

    更新日期：2005-04-15 00:00:00

  • Bifurcation dynamics in lineage-commitment in bipotent progenitor cells.

    abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.02.036

    authors： Huang S,Guo YP,May G,Enver T

    更新日期：2007-05-15 00:00:00

  • Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination.

    abstract：:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.10.029

    authors： Kolotuev I,Podbilewicz B

    更新日期：2004-02-15 00:00:00

  • Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate.

    abstract：:The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.500

    authors： Rinkevich Y,Rosner A,Rabinowitz C,Lapidot Z,Moiseeva E,Rinkevich B

    更新日期：2010-09-01 00:00:00

  • Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3.

    abstract：:All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.08.026

    authors： Stetak A,Gutierrez P,Hajnal A

    更新日期：2008-11-15 00:00:00

  • Conditional Aurora A deficiency differentially affects early mouse embryo patterning.

    abstract：:Aurora A is a mitotic kinase essential for cell proliferation. In mice, ablation of Aurora A results in mitotic arrest and pre-implantation lethality, preventing studies at later stages of development. Here we report the effects of Aurora A ablation on embryo patterning at early post-implantation stages. Inactivation ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.08.010

    authors： Yoon Y,Cowley DO,Gallant J,Jones SN,Van Dyke T,Rivera-Pérez JA

    更新日期：2012-11-01 00:00:00

  • Post-translational control of ribosomal protein L1 accumulation in Xenopus oocytes.

    abstract：:A functional ribosomal protein mRNA, encoding the 60 S subunit protein L1, has been synthesized in vitro using bacteriophage SP6 RNA polymerase. This mRNA directs the synthesis of a product indistinguishable from L1 protein purified from Xenopus ovarian ribosomes. Our results show that L1 synthesis in stage VI oocytes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90247-3

    authors： Baum EZ,Hyman LE,Wormington WM

    更新日期：1988-03-01 00:00:00

  • Morphogenesis and motility of the Astyanax mexicanus gastrointestinal tract.

    abstract：:Through the course of evolution, the gastrointestinal (GI) tract has been modified to maximize nutrient absorption, forming specialized segments that are morphologically and functionally distinct. Here we show that the GI tract of the Mexican tetra, Astyanax mexicanus, has distinct regions, exhibiting differences in m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.06.004

    authors： Riddle MR,Boesmans W,Caballero O,Kazwiny Y,Tabin CJ

    更新日期：2018-09-15 00:00:00

  • Cavitation in the mouse preimplantation embryo: Na/K-ATPase and the origin of nascent blastocoele fluid.

    abstract：:This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90290-2

    authors： Wiley LM

    更新日期：1984-10-01 00:00:00

  • The effect of agrin and laminin on acetylcholine receptor dynamics in vitro.

    abstract：:Using optical imaging assays, we investigated the dynamics of acetylcholine receptors (AChRs) at laminin-associated clusters on cultured myotubes in the absence or presence of the nerve-derived clustering factor, agrin. Using fluorescence recovery after photobleaching (FRAP) on fluorescent bungarotoxin-labeled recepto...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.09.041

    authors： Bruneau EG,Macpherson PC,Goldman D,Hume RI,Akaaboune M

    更新日期：2005-12-01 00:00:00

  • A perturbation model of the gene regulatory network for oral and aboral ectoderm specification in the sea urchin embryo.

    abstract：:The current gene regulatory network (GRN) for the sea urchin embryo pertains to pregastrular specification functions in the endomesodermal territories. Here we extend gene regulatory network analysis to the adjacent oral and aboral ectoderm territories over the same period. A large fraction of the regulatory genes pre...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.02.029

    authors： Su YH,Li E,Geiss GK,Longabaugh WJ,Krämer A,Davidson EH

    更新日期：2009-05-15 00:00:00

  • The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis.

    abstract：:We have characterized a phosphoprotein protein with a death effector domain that has a novel bifunctional role in programmed cell death. The 15-kDa phosphoprotein enriched in astrocytes (PEA-15) inhibits Fas-mediated apoptosis and increases tumor necrosis factor receptor-1 (TNF-R1)-mediated apoptosis in the same cell ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9510

    authors： Estellés A,Charlton CA,Blau HM

    更新日期：1999-12-01 00:00:00

  • Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth.

    abstract：:The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.12.024

    authors： Pennimpede T,Cameron DA,MacLean GA,Petkovich M

    更新日期：2010-03-01 00:00:00