Abstract:
:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-step process of vulva formation has been studied in wild type and in several mutants. Here we show that cellular processes during vulva development, which involve toroidal cell formation and stacking of rings, are conserved between C. elegans and Pristionchus pacificus, two species of nematodes that diverged approximately 100 million years ago. These cellular behaviors are divided into phases of cell proliferation, short-range migration, and cell fusion that are temporally distinct in C. elegans but not in P. pacificus. Thus, we identify heterochronic changes in the cellular events of vulva development between these two species. We find that alterations in the division axes of two equivalent vulval cells from Left-Right cleavage in C. elegans to Anterior-Posterior division in P. pacificus can cause the formation of an additional eighth ring. Thus, orthogonal changes in cell division axes with alterations in the number and sequence of cell fusion events result in dramatic differences in vulval shape and in the number of rings in the species studied. Our characterization of vulva formation in P. pacificus compared to C. elegans provides an evolutionary-developmental foundation for molecular genetic analyses of organogenesis in different species within the phylum Nematoda.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Kolotuev I,Podbilewicz Bdoi
10.1016/j.ydbio.2003.10.029subject
Has Abstractpub_date
2004-02-15 00:00:00pages
322-33issue
2eissn
0012-1606issn
1095-564Xpii
S0012160603006663journal_volume
266pub_type
杂志文章abstract::We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential rol...
journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:2006-03-15 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
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pub_type: 杂志文章,评审
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更新日期:2018-12-01 00:00:00
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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abstract::Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9314
更新日期:1999-07-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9865
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journal_title:Developmental biology
pub_type: 杂志文章,评审
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abstract::Much of boundary formation during development remains to be understood, despite being a defining feature of many animal taxa. Axial patterning of Hydra, a member of the ancient phylum Cnidaria which diverged prior to the bilaterian radiation, involves a steady-state of production and loss of tissue, and is dependent o...
journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.01.008
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00255-0
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abstract::The Mix/Bix family of paired-like homeobox genes encode evolutionarily conserved, sequence specific, DNA-binding transcription factors that have been implicated in the co-ordination of gene expression, axis formation and cell fate determination during gastrulation in vertebrates. When mutated, these genes give rise to...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2012.04.033
更新日期:2012-07-15 00:00:00
abstract::In Hydra long-range interactions between head, bud, and foot formation take place in addition to short-range interactions which are recognized as induction phenomena, occurring when transplants are placed into an environment of disparate positional value. Here the long-range promotion of foot formation is analyzed. Th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1015
更新日期:1995-01-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.03.005
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journal_title:Developmental biology
pub_type: 杂志文章
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doi:10.1016/0012-1606(89)90112-7
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1142
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abstract::Congenital bony syngnathia, a rare but severe human birth defect, is characterized by bony fusion of the mandible to the maxilla. However, the genetic mechanisms underlying this birth defect are poorly understood, largely due to limitation of available animal models. Here we present evidence that transgenic expression...
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pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.04.013
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90050-2
更新日期:1984-07-01 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0126
更新日期:1996-06-15 00:00:00
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pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(81)90410-3
更新日期:1981-06-01 00:00:00
abstract::Mammalian sperm-egg adhesion occurs when sperm bind to the zona pellucida of the egg. In this study with guinea pig gametes, we have asked if sperm can initiate binding to the zona before and after the acrosome reaction and if the sperm surface protein PH-20 is involved in the binding at these two stages. Sperm bindin...
journal_title:Developmental biology
pub_type: 杂志文章
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