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C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.

Abstract：

:The control of cell division is critical to organogenesis, but how this control is achieved is not fully understood. We found that mutations in bed-3, encoding a BED Zn-finger domain transcription factor, confer a phenotype where a specific set of cell divisions during vulval organogenesis is lost. Unlike general cell cycle regulators in Caenorhabditis elegans, the function of bed-3 is restricted to specific lineages. Transcriptional reporters suggest that bed-3 is expressed in a limited number of cell types including vulval cells whose divisions are affected in bed-3 mutants. A bed-3 mutation also affects the expression pattern of the cdh-3 cadherin gene in the vulva. The phenotype of bed-3 mutants is similar to the phenotype caused by mutations in cog-1 (Nkx6), a component of a gene regulatory network controlling cell type specific gene expression in the vulval lineage. These results suggest that bed-3 is a key component linking the gene regulatory network controlling cell-type specification to control of cell division during vulval organogenesis.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Inoue T,Sternberg PW

doi

10.1016/j.ydbio.2009.12.005

subject

Has Abstract

pub_date

2010-02-15 00:00:00

pages

226-36

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(09)01394-3

journal_volume

338

pub_type

杂志文章

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