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Piwi positive cells that line the vasculature epithelium, underlie whole body regeneration in a basal chordate.

Abstract：

:The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization and expansion of 'dormant' cells which normally line the internal vasculature epithelium of blood vessels. Following a mechanical insult, these cells express Bl-Piwi de novo, change morphology and invade niches of the vasculature lumen, where they proliferate and differentiate, regenerating a functional organism. Mitomycin C treatments and siRNA knockdown of Bl-Piwi result in deficient cells incapable of expanding or differentiating and to subsequent regeneration arrest. Last, we find similar transient mobilization of Piwi(+) cells recurring every week, as part of normal colony development, and also during acute environmental stress. This recurrent activation of Piwi(+) cells in response to developmental, physiological and environmental insults may have enabled the adaptation of colonial tunicates to the imposed varied conditions in the marine, shallow water environment.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Rinkevich Y,Rosner A,Rabinowitz C,Lapidot Z,Moiseeva E,Rinkevich B

doi

10.1016/j.ydbio.2010.05.500

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

94-104

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(10)00803-1

journal_volume

345

pub_type

杂志文章

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