Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness.

abstract：:Xenopus laevis frogs from laboratory stocks normally lay eggs exhibiting extensive size variability. We find that these initial size differences subsequently affect the size of the embryos prior to the onset of growth, and the size of tadpoles during the growth period. Even though these tadpoles differ in size, their ...

journal_title：Developmental biology

authors： Leibovich A,Edri T,Klein SL,Moody SA,Fainsod A

更新日期：2020-06-15 00:00:00

abstract：:At gastrulation in the sea urchin embryo dramatic cell adhesion changes contribute to primary mesenchyme cell ingression movements and to cell rearrangements during archenteron invagination. At ingression, quantitative adhesion assays demonstrated previously that primary mesenchyme cells (PMCs) change their affinity f...

journal_title：Developmental biology

authors： Hertzler PL,McClay DR

更新日期：1999-03-01 00:00:00

abstract：:Epidermal growth factor (EGF), a low-molecular-weight polypeptide (G. Carpenter and S. Cohen, 1979, Annu. Rev. Biochem. 48, 193-216), stimulates the proliferation and keratinisation of cultured embryonic epidermis (S. Cohen, 1965, Dev. Biol. 12, 394-407) and promotes epidermal growth, thickening, and keratinisation wh...

journal_title：Developmental biology

authors： Green MR,Basketter DA,Couchman JR,Rees DA

更新日期：1983-12-01 00:00:00

abstract：:The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...

journal_title：Developmental biology

authors： Grafi G

更新日期：2004-04-01 00:00:00

abstract：:Initial studies suggested that spatial organization of the putative polar body contractile ring was determined by the peripheral aster in Spisula [Biol. Bull. 205 (2003) 192]. Here we report detailed supporting observations, including testing of aster and ring function with inhibitors. The metaphase peripheral aster w...

journal_title：Developmental biology

authors： Pielak RM,Gaysinskaya VA,Cohen WD

更新日期：2004-05-15 00:00:00

abstract：:Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem ...

journal_title：Developmental biology

authors： Tropepe V,Sibilia M,Ciruna BG,Rossant J,Wagner EF,van der Kooy D

更新日期：1999-04-01 00:00:00

abstract：:Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...

journal_title：Developmental biology

authors： Haley SA,Wessel GM

更新日期：1999-07-01 00:00:00

abstract：:Lipids are essential for cellular function as sources of fuel, critical signaling molecules and membrane components. Deficiencies in lipid processing and transport underlie many metabolic diseases. To better understand metabolic function as it relates to disease etiology, a whole animal approach is advantageous, one i...

journal_title：Developmental biology

authors： Carten JD,Bradford MK,Farber SA

更新日期：2011-12-15 00:00:00

abstract：:Fertilization results in the tyrosine phosphorylation of several egg proteins within minutes of sperm-egg binding and inhibitor studies have shown that tyrosine kinase activity is required for many aspects of egg activation. The present study demonstrates the presence of p59c-fyn kinase in the sea urchin egg and exami...

journal_title：Developmental biology

authors： Kinsey WH

更新日期：1996-03-15 00:00:00

abstract：:The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...

journal_title：Developmental biology

authors： Shi C,Muneoka K

更新日期：1992-05-01 00:00:00

abstract：:The development of neural crest-derived melanocytes, as well as haematopoietic and germ cells, is affected by mutations of the Kit and Mgf genes, which lead to dominant spotting (W) or steel (Sl) phenotypes. Mgf codes for the ligand of the receptor tyrosine kinase encoded by the Kit locus. KitW-v, a point mutation exe...

journal_title：Developmental biology

authors： Mackenzie MA,Jordan SA,Budd PS,Jackson IJ

更新日期：1997-12-01 00:00:00

abstract：:Metaphase II arrest of Xenopus oocyte is characterized by the presence of M-phase-promoting factor (MPF) and of a microtubular spindle, both of which are stable in the presence of protein synthesis inhibitors. We studied in vivo this equilibrium state that is settled during meiotic maturation. At time of germinal vesi...

journal_title：Developmental biology

authors： Thibier C,De Smedt V,Poulhe R,Huchon D,Jessus C,Ozon R

更新日期：1997-05-01 00:00:00

abstract：:Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evol...

journal_title：Developmental biology

authors： Rohith BN,Shyamala BV

更新日期：2017-12-15 00:00:00

abstract：:Temporal and spatial aspects of floral determination in seedling terminal buds of the qualitative short-day plant Pharbitis nil were examined using a grafting assay. Floral determination in the terminal buds of 6-day-old P. nil seedlings is rapid; by 9 hr after the end of a 14-hr inductive dark period more than 50% of...

journal_title：Developmental biology

authors： Larkin JC,Felsheim R,Das A

更新日期：1990-02-01 00:00:00

abstract：:Sea urchin eggs secrete a serine protease activity, CGSP1, at fertilization that is essential for the block to polyspermy. Several targets of this proteolytic activity on the plasma membrane were identified here using a cell surface biotinylation approach. Amino acid microsequencing of one of these proteins led to the...

journal_title：Developmental biology

authors： Haley SA,Wessel GM

更新日期：2004-08-01 00:00:00

abstract：:In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3...

journal_title：Developmental biology

authors： Lallemand Y,Bensoussan V,Cloment CS,Robert B

更新日期：2009-07-15 00:00:00

abstract：:Single cells from 512-cell Xenopus embryos, totally labeled with intracellular horseradish peroxidase, were transplanted orthotopically (from either dorsal or lateral marginal zone) or heterotopically (between these two marginal zones) to unlabeled host embryos at the 512-cell stage. At tailbud stage 23 the locations,...

journal_title：Developmental biology

authors： Jacobson M,Xu WL

更新日期：1989-01-01 00:00:00

abstract：:It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to iden...

journal_title：Developmental biology

authors： Stephan JP,Bald L,Roberts PE,Lee J,Gu Q,Mather JP

更新日期：1999-08-15 00:00:00

abstract：:Neural stem cells are present in specific regions of the adult central nervous system (CNS). Recent evidence suggests that the ciliary epithelium (CE), a CNS derivative, in the adult mammalian eye, harbors a quiescent population of neural stem cells. Here, we report the identification of c-Kit signaling as one of the ...

journal_title：Developmental biology

authors： Das AV,James J,Zhao X,Rahnenführer J,Ahmad I

更新日期：2004-09-01 00:00:00

abstract：:Summary Sentence: Conditional ablation of AP-2 gamma results in a delay in skin development and abnormal expression of p63, K14, K1, filaggrin, repetin and secreted Ly6/Plaur domain containing 1, key genes required for epidermal development and differentiation. The development of the epidermis, a stratified squamous e...

journal_title：Developmental biology

authors： Guttormsen J,Koster MI,Stevens JR,Roop DR,Williams T,Winger QA

更新日期：2008-05-01 00:00:00

abstract：:Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested t...

journal_title：Developmental biology

authors： Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl M

更新日期：2008-09-01 00:00:00

abstract：:The axonal functions that act in the formation of the neuronal network have been shown to occur in close interdependence with the tissue that surrounds the growing axons. However, little is known about the molecular building blocks underlying axonal functions, although more than 400 axonal proteins have been identifie...

journal_title：Developmental biology

authors： Sonderegger P,Lemkin PF,Lipkin LE,Nelson PG

更新日期：1986-11-01 00:00:00

abstract：:Patterning of the early neural tube is achieved in part by the inductive signals, which arise from neuroepithelial signaling centers. The zona limitans intrathalamica (ZLI) is a neuroepithelial domain in the alar plate of the diencephalon which separates the prethalamus from the thalamus. The ZLI has recently been con...

journal_title：Developmental biology

authors： Vieira C,Garda AL,Shimamura K,Martinez S

更新日期：2005-08-15 00:00:00

abstract：:A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...

journal_title：Developmental biology

authors： Drazba J,Pierce M,Lemmon V

更新日期：1991-05-01 00:00:00

abstract：:Fibronectin (Fn) plays an important part in the branching morphogenesis of salivary gland, lung, and kidney. Here, we examine the effect of the conditional knockout of Fn in the mammary epithelium [Fn(MEp-/-)] on postnatal mammary gland development, using Cre-loxP-mediated gene knockout technology. Our data show that ...

journal_title：Developmental biology

authors： Liu K,Cheng L,Flesken-Nikitin A,Huang L,Nikitin AY,Pauli BU

更新日期：2010-10-01 00:00:00

abstract：:Ephrin-B2, a member of the Eph/ephrin family of cell signaling molecules, has been implicated in the guidance of cranial and trunk neural crest cells (NCC) and development of the branchial arches(BA), but detailed examination in mice has been hindered by embryonic lethality of Efnb2 null loss of function due to a requ...

journal_title：Developmental biology

authors： Lewis AE,Hwa J,Wang R,Soriano P,Bush JO

更新日期：2015-10-15 00:00:00

abstract：:Genetic interactions regulating intermediate stages of tubulogenesis in the developing kidney have been difficult to define. A systems biology strategy using microarray was combined with in vitro/ex vivo and genetic approaches to identify pathways regulating specific stages of tubulogenesis. Analysis of the progressio...

journal_title：Developmental biology

authors： Gallegos TF,Kouznetsova V,Kudlicka K,Sweeney DE,Bush KT,Willert K,Farquhar MG,Nigam SK

更新日期：2012-04-01 00:00:00

abstract：:Metathoracic limb buds were removed unilaterally from Locusta migratoria embryos at 30% of embryonic development, thereby depriving limb-innervating neurons of the opportunity of innervating their normal target muscles. The operated embryos were allowed to hatch and develop to adulthood, and then the connections betwe...

journal_title：Developmental biology

authors： Whitington PM

更新日期：1985-02-01 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00

abstract：:We investigated the potential role of rostral-caudal and dorsal-ventral subdivisions of the early rostral brain by relating these subdivisions to the early patterning of neuron cell bodies and their axon projections. The earliest neurons were mapped using the lipophilic axon tracers diI and diO on embryos fixed on emb...

journal_title：Developmental biology

authors： Mastick GS,Easter SS Jr

更新日期：1996-01-10 00:00:00