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Identification of c-Kit receptor as a regulator of adult neural stem cells in the mammalian eye: interactions with Notch signaling.

Abstract：

:Neural stem cells are present in specific regions of the adult central nervous system (CNS). Recent evidence suggests that the ciliary epithelium (CE), a CNS derivative, in the adult mammalian eye, harbors a quiescent population of neural stem cells. Here, we report the identification of c-Kit signaling as one of the regulators of adult CE neural stem cells in vitro. c-Kit receptors are expressed in proliferating adult CE neural stem cells and colocalized with neural progenitor markers. Perturbation of c-Kit signaling influences the self-renewal and differentiation of CE neural stem cells, thus demonstrating the role of c-Kit signaling in the maintenance of these cells. In addition, we observed an influence of c-Kit-mediated signaling on the expression of Notch1, another critical regulator of neural stem cells. Our observations suggest that, given the importance of preservation of a stem cell pool for generating different cell types at different times, multiple signaling pathways act in concert for the maintenance of neural stem cells.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Das AV,James J,Zhao X,Rahnenführer J,Ahmad I

doi

10.1016/j.ydbio.2004.05.023

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

87-105

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012160604003902

journal_volume

273

pub_type

杂志文章

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