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The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel.

Abstract：

:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in the cardiac mesoderm and is subsequently restricted to cells forming the cardiac inflow tracts. Here, we investigate svp regulation in the developing cardiac tube. Using bioinformatics, we identify a 1007-bp enhancer of svp which recapitulates its entire expression in the embryonic heart and other mesodermal derivatives, and we show that this enhancer is initially activated by the NK homeodomain factor Tinman (Tin) via two conserved Tin binding sites. Mutation of the Tin binding sites significantly reduces enhancer activity both during normal development and in response to ectopic Tin. This is the first identification of an enhancer for the complex svp gene, demonstrating the effectiveness of bioinformatics tools in assisting in unraveling transcriptional regulatory networks. Our studies define a critical component of the svp regulatory cascade and place gene regulatory events in direct apposition to the formation of critical cardiac structures.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Ryan KM,Hendren JD,Helander LA,Cripps RM

doi

10.1016/j.ydbio.2006.10.025

subject

Has Abstract

pub_date

2007-02-15 00:00:00

pages

694-702

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(06)01317-0

journal_volume

302

pub_type

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