Abstract:
:Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested to be a target gene of non-canonical Wnt signalling. Loss of DM-GRASP function did not affect specification of cardiac progenitor cells. Later during development, expression of cardiac marker genes in the first heart field of Xenopus laevis such as Tbx20 and TnIc was reduced, whereas expression of the second heart field marker genes Isl-1 and BMP-4 was unaffected. Furthermore, loss of DM-GRASP function resulted in defective cell adhesion and cardiac morphogenesis. Additionally, expression of DM-GRASP can rescue the phenotype that results from the loss of non-canonical Wnt11-R signalling suggesting that DM-GRASP and non-canonical Wnt signalling are functionally coupled during cardiac development.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl Mdoi
10.1016/j.ydbio.2008.06.013subject
Has Abstractpub_date
2008-09-01 00:00:00pages
150-61issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(08)01003-8journal_volume
321pub_type
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