Formation of nucleus-like structure in the cytoplasm of lambda-DNA-injected fertilized eggs and its partition into blastomeres during early embryogenesis in Xenopus laevis.

abstract：:Single cells from 512-cell Xenopus embryos, totally labeled with intracellular horseradish peroxidase, were transplanted orthotopically (from either dorsal or lateral marginal zone) or heterotopically (between these two marginal zones) to unlabeled host embryos at the 512-cell stage. At tailbud stage 23 the locations,...

journal_title：Developmental biology

authors： Jacobson M,Xu WL

更新日期：1989-01-01 00:00:00

abstract：:In the embryonic mouse retina, retinoic acid (RA) is unevenly distributed along the dorsoventral axis: RA-rich zones in dorsal and ventral retina are separated by a horizontal RA-poor stripe that contains the RA-inactivating enzyme CYP26A1. To explore the developmental role of this arrangement, we studied formation of...

journal_title：Developmental biology

authors： Sakai Y,Luo T,McCaffery P,Hamada H,Dräger UC

更新日期：2004-12-01 00:00:00

abstract：:To investigate the mechanism by which the hormone 17 alpha,20 beta-dihydroxy-4-pregnen-3-one(17 alpha,20 beta-DP) acts on a receptor on the external surface of rainbow trout oocytes to induce maturation, the interaction between 17 alpha,20 beta-DP receptors and G-proteins was examined. Pertussis toxin (PT) catalyzed t...

journal_title：Developmental biology

authors： Yoshikuni M,Nagahama Y

更新日期：1994-12-01 00:00:00

abstract：:Axon outgrowth between the spinal cord and the hindlimb of the chick embryo is constrained by three tissues that border axon pathways. Growth cones turn to avoid the posterior sclerotome, perinotochordal mesenchyme, and pelvic girdle precursor during normal development and after experimental manipulation. We wanted to...

journal_title：Developmental biology

authors： Oakley RA,Tosney KW

更新日期：1991-09-01 00:00:00

abstract：:Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...

journal_title：Developmental biology

authors： Bruder SP,Caplan AI

更新日期：1990-10-01 00:00:00

abstract：:The vertebrate intestinal epithelium is renewed continuously from stem cells at the base of the crypt in mammals or base of the fold in fish over the life of the organism. As stem cells divide, newly formed epithelial cells make an initial choice between a secretory or enterocyte fate. This choice has previously been ...

journal_title：Developmental biology

authors： Roach G,Heath Wallace R,Cameron A,Emrah Ozel R,Hongay CF,Baral R,Andreescu S,Wallace KN

更新日期：2013-04-15 00:00:00

abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

journal_title：Developmental biology

authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

更新日期：2006-03-01 00:00:00

abstract：:The respective role of Pax2 and Pax8 in early kidney development in vertebrates is poorly understood. In this report, we have studied the roles of Pax8 and Pax2 in Xenopus pronephros development using a loss-of-function approach. Our results highlight a differential requirement of these two transcription factors for p...

journal_title：Developmental biology

authors： Buisson I,Le Bouffant R,Futel M,Riou JF,Umbhauer M

更新日期：2015-01-15 00:00:00

abstract：:Somatic embryogenesis is one of the best examples of the remarkable developmental plasticity of plants, in which committed somatic cells can dedifferentiate and acquire the ability to form an embryo and regenerate an entire plant. In Arabidopsis thaliana, the shoot apices of young seedlings have been reported as an al...

journal_title：Developmental biology

authors： Kadokura S,Sugimoto K,Tarr P,Suzuki T,Matsunaga S

更新日期：2018-10-01 00:00:00

abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

journal_title：Developmental biology

authors： Levitan D,Yu G,St George Hyslop P,Goutte C

更新日期：2001-12-15 00:00:00

abstract：:An important developmental question concerns whether neurotransmitter phenotype is an inherent property of neurons or is influenced by target tissues. This issue can be addressed in the avian ciliary ganglion (CG) which contains two cholinergic populations, ciliary and choroid neurons, that differentially express the ...

journal_title：Developmental biology

authors： Darland DC,Nishi R

更新日期：1998-10-15 00:00:00

abstract：:Lipids are essential for cellular function as sources of fuel, critical signaling molecules and membrane components. Deficiencies in lipid processing and transport underlie many metabolic diseases. To better understand metabolic function as it relates to disease etiology, a whole animal approach is advantageous, one i...

journal_title：Developmental biology

authors： Carten JD,Bradford MK,Farber SA

更新日期：2011-12-15 00:00:00

abstract：:Division of a female Drosophila stem cell produces a daughter stem cell and a cystoblast. The cystoblast produces a syncytial cluster of 16 cells by precisely four mitotic divisions and incomplete cytokinesis. Mutations in genes required for cystoblast differentiation, such as bag-of-marbles, block syncytial cluster f...

journal_title：Developmental biology

authors： Lavoie CA,Ohlstein B,McKearin DM

更新日期：1999-08-15 00:00:00

abstract：:Smad4 is defined as the common-mediator Smad (co-Smad) required for transducing signals for all TGF-beta superfamily members. This paper describes two Smad4s in Xenopus: XSmad4alpha, which is probably the Xenopus orthologue of human Smad4, and a distinct family member, XSmad4beta, which differs primarily at the extrem...

journal_title：Developmental biology

authors： Howell M,Itoh F,Pierreux CE,Valgeirsdottir S,Itoh S,ten Dijke P,Hill CS

更新日期：1999-10-15 00:00:00

abstract：:The Foxl1 gene, which encodes a winged helix transcriptional regulator, is expressed in the mesenchymal layer of developing and mature gastrointestinal tract. Foxl1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the ...

journal_title：Developmental biology

authors： Fukuda K,Yoshida H,Sato T,Furumoto TA,Mizutani-Koseki Y,Suzuki Y,Saito Y,Takemori T,Kimura M,Sato H,Taniguchi M,Nishikawa S,Nakayama T,Koseki H

更新日期：2003-03-15 00:00:00

abstract：:In this paper we present a structural and functional characterization of a new sea urchin embryo transcription factor, SpRunt-1. This factor was isolated by means of its specific interaction with a cis-regulatory target site of the CyIIIa gene. Here we show that this target site, the P7I site, is required for normal e...

journal_title：Developmental biology

authors： Coffman JA,Kirchhamer CV,Harrington MG,Davidson EH

更新日期：1996-02-25 00:00:00

abstract：:The large ampullate glands of the orb-web spider, Nephila clavipes provide massive amounts of fibroin throughout the lifetime of the adult female. We have developed methods to culture the glands and manipulate their biosynthetic activity. This has allowed us to monitor a series of molecular events that precede silk pr...

journal_title：Developmental biology

authors： Candelas GC,Arroyo G,Carrasco C,Dompenciel R

更新日期：1990-07-01 00:00:00

abstract：:Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 recep...

journal_title：Developmental biology

authors： Goswami M,Uzgare AR,Sater AK

更新日期：2001-08-15 00:00:00

abstract：:To investigate the spatiotemporal dynamics of skin pattern formation, we developed a simple method for artificially disarranging the placement of all three pigment cell types in the body trunk of zebrafish (Danio rerio). We generated transgenic fish with melanophores that ectopically expressed a variant of channelrhod...

journal_title：Developmental biology

authors： Aramaki T,Kondo S

更新日期：2020-04-01 00:00:00

abstract：:Climate change is multi-faceted, and includes changing concentrations of greenhouse gases in the atmosphere, rising temperatures, changes in precipitation patterns, and increasing frequency of extreme weather events. Here, we focus on the effects of rising atmospheric CO2 concentrations, rising temperature, and drough...

journal_title：Developmental biology

authors： Gray SB,Brady SM

更新日期：2016-11-01 00:00:00

abstract：:This study tested the proposition that Na/K-ATPase activity could be involved in the morphogenetic aspects of mouse blastocyst formation by facilitating the localization of certain organelles to apposed borders, the production of nascent blastocoele fluid, and cavitation. It was assumed that such Na/K-ATPase activity ...

journal_title：Developmental biology

authors： Wiley LM

更新日期：1984-10-01 00:00:00

abstract：:Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physical...

journal_title：Developmental biology

authors： Shoguchi E,Hamaguchi M,Satoh N

更新日期：2008-04-15 00:00:00

abstract：:Eye cups from stage 14-28 (E2 to E5) chick and quail embryos consisting of neural retina, lens, and vitreous body were cultured for 1 or 2 days. These eyes expanded by proliferation of the retinal cells and the surface areas of the retinae increased several-fold. The area covered by ganglion cells and axons also expan...

journal_title：Developmental biology

authors： Halfter W,Deiss S

更新日期：1986-04-01 00:00:00

abstract：:The rise of evolutionary developmental biology was not the progressive isolation and characterization of developmental genes and gene networks. Many obstacles had to be overcome: the idea that all genes were more or less involved in development; the evidence that developmental processes in insects had nothing in commo...

journal_title：Developmental biology

authors： Morange M

更新日期：2011-09-01 00:00:00

abstract：:We have investigated the function of the neurogenic gene Notch (N) during development of the adult sensilla of Drosophila. Heat pulses were applied to flies carrying the temperature-sensitive Notch allele Nts1 at different larval and pupal stages. We can show that the reduction of Notch+ function during a short interv...

journal_title：Developmental biology

authors： Hartenstein V,Posakony JW

更新日期：1990-11-01 00:00:00

abstract：:Chromatin regulators contribute to the developmental control of gene expression. In the nematode Caenorhabditis elegans, the roles of chromatin regulation in development have been explored in several contexts, including vulval differentiation. The synthetic multivulva (synMuv) genes are regulators of vulval developmen...

journal_title：Developmental biology

authors： Yücel D,Hoe M,Llamosas E,Kant S,Jamieson C,Young PA,Crossley M,Nicholas HR

更新日期：2014-08-15 00:00:00

abstract：:FbxA is a novel member of a family of proteins that contain an F-box and WD40 repeats and that target specific proteins for degradation via proteasomes. In fruiting bodies formed from cells where the fbxA gene is disrupted (fbxA(-) cells), the spore mass fails to fully ascend the stalk. In addition, fbxA(-) slugs cont...

journal_title：Developmental biology

authors： Nelson MK,Clark A,Abe T,Nomura A,Yadava N,Funair CJ,Jermyn KA,Mohanty S,Firtel RA,Williams JG

更新日期：2000-08-01 00:00:00

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

journal_title：Developmental biology

authors： Hemberger M,Hughes M,Cross JC

更新日期：2004-07-15 00:00:00

abstract：:Lens growth involves the proliferation of epithelial cells, followed by their migration to the equator region and differentiation into secondary fiber cells. It is widely accepted that fibroblast growth factor (FGF) signaling is required for the differentiation of lens epithelial cells into crystallin-rich fibers, but...

journal_title：Developmental biology

authors： Song X,Sato Y,Felemban A,Ito A,Hossain M,Ochiai H,Yamamoto T,Sekiguchi K,Tanaka H,Ohta K

更新日期：2012-08-01 00:00:00