An F-Box/WD40 repeat-containing protein important for Dictyostelium cell-type proportioning, slug behaviour, and culmination.

abstract：:Dictyostelium discoideum is a simple eukaryote that lives as an amoeba until starvation triggers aggregation. The aggregate forms a slug which then develops into a fruiting body with two main cell types, stalk and spore cells. Two mechanisms have been proposed to explain cell-type differentiation. Studies using expres...

journal_title：Developmental biology

authors： Clay JL,Ammann RR,Gomer RH

更新日期：1995-12-01 00:00:00

abstract：:High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of the intervertebral disc. Indeed, the osmoadaptive transcription factor, nuclear factor of activated T-cells 5 (NFAT5 aka TonEBP), is robustly expressed by residen...

journal_title：Developmental biology

authors： Tessier S,Madhu V,Johnson ZI,Shapiro IM,Risbud MV

更新日期：2019-11-15 00:00:00

abstract：:The role of fibronectin in mesoderm cell migration and and the importance of mesoderm migration for gastrulation in Xenopus are examined. To allow for migration, a stable interface must exist between migrating mesoderm cells and the cells of the substrate layer, the blastocoel roof. We show that maintenance of this in...

journal_title：Developmental biology

authors： Winklbauer R,Keller RE

更新日期：1996-08-01 00:00:00

abstract：:Previous studies have suggested a role of the homeodomain Six family proteins in patterning the developing vertebrate head that involves appropriate segmentation of three tissue layers, the endoderm, the paraxial mesoderm and the neural crest cells; however, the developmental programs and mechanisms by which the Six g...

journal_title：Developmental biology

authors： Zou D,Silvius D,Davenport J,Grifone R,Maire P,Xu PX

更新日期：2006-05-15 00:00:00

abstract：:Sex in the nematode Caenorhabditis elegans is normally determined by the X chromosome to autosome (X:A) ratio, with XX hermaphrodites and XO males. Previous work has shown that a set of at least four autosomal genes (her-1, tra-2, tra-3, and tra-1) is signaled by the X:A ratio and appears to act in a regulatory pathwa...

journal_title：Developmental biology

authors： Doniach T,Hodgkin J

更新日期：1984-11-01 00:00:00

abstract：:Cell surface and cytoplasmic polarity is exhibited by the blastomeres of mouse preimplantation embryos following compaction at the 8-cell stage of cleavage. It has been hypothesized that cytoplasmic polarity is initiated by plasma membrane functions of polar blastomeres that are absent from apolar blastomeres. To test...

journal_title：Developmental biology

authors： Wiley LM,Obasaju MF

更新日期：1988-11-01 00:00:00

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated mRNAs from a target...

journal_title：Developmental biology

authors： Whitworth GB,Misaghi BC,Rosenthal DM,Mills EA,Heinen DJ,Watson AH,Ives CW,Ali SH,Bezold K,Marsh-Armstrong N,Watson FL

更新日期：2017-06-15 00:00:00

abstract：:In the developing vertebrate brain, growing axons establish a scaffold of axon tracts connected across the midline via commissures. We have previously identified a population of telencephalic neurons that express NOC-2, a novel glycoform of the neural cell adhesion molecule N-CAM that is involved in axon guidance in t...

journal_title：Developmental biology

authors： Anderson RB,Cooper HM,Jackson SC,Seaman C,Key B

更新日期：2000-01-15 00:00:00

abstract：:During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

journal_title：Developmental biology

authors： Moss SB,Challoner PB,Groudine M

更新日期：1989-05-01 00:00:00

abstract：:We have isolated Xbr-1, a novel Xenopus homeobox gene that defines a new class of homeobox genes, distantly related to the Drosophila BarH1 and BarH2 genes. Xbr-1 is predominantly expressed in the developing Xenopus eye, starting as early as the neural plate stage. At early stages of eye development XBR-1 is expressed...

journal_title：Developmental biology

authors： Papalopulu N,Kintner C

更新日期：1996-02-25 00:00:00

abstract：:We have investigated the imprinting status of two insulin genes using an interspecific recombinant congenic mouse strain carrying Ins1 and Ins2 alleles from Mus spretus on a C57BL/6 genetic background. At Days 12.5, 13.5, and 14.5 of gestation, expression of both parental alleles of both Ins1 and Ins2 was detected in ...

journal_title：Developmental biology

authors： Deltour L,Montagutelli X,Guenet JL,Jami J,Páldi A

更新日期：1995-04-01 00:00:00

abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

journal_title：Developmental biology

authors： Jones KT,Nixon VL

更新日期：2000-09-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively regulates a number of cellular signaling events including canonical Wnt signaling. Activation of the Wnt/beta-catenin pathway is essential for dorsal organizer formation and specification in early vertebrate embryos, but it remai...

journal_title：Developmental biology

authors： Mo S,Wang L,Li Q,Li J,Li Y,Thannickal VJ,Cui Z

更新日期：2010-08-01 00:00:00

abstract：:A protein complex consisting of Mago Nashi and Tsunagi/Y14 is required to establish the major body axes and for the localization of primordial germ cell determinants during Drosophila melanogaster oogenesis. The Mago Nashi:Tsunagi/Y14 heterodimer also serves as the core of the exon junction complex (EJC), a multiprote...

journal_title：Developmental biology

authors： Parma DH,Bennett PE Jr,Boswell RE

更新日期：2007-08-15 00:00:00

abstract：:We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...

journal_title：Developmental biology

authors： Mitchell HK,Petersen NS

更新日期：1983-02-01 00:00:00

abstract：:In ascidian embryos, the earliest transcription from the zygotic genome begins between the 8-cell and 16-cell stages. Gata.a, a maternally expressed Gata transcription factor, activates target genes specifically in the animal hemisphere, whereas the complex of β-catenin and Tcf7 antagonizes the activity of Gata.a and ...

journal_title：Developmental biology

authors： Imai KS,Kobayashi K,Kari W,Rothbächer U,Ookubo N,Oda-Ishii I,Satou Y

更新日期：2020-02-15 00:00:00

abstract：:During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

journal_title：Developmental biology

authors： Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

更新日期：2014-02-01 00:00:00

abstract：:During metamorphosis, the steroid hormone 20-hydroxyecdysone induces morphogenesis of imaginal discs, including the formation of appendages. IMP-E2 is an ecdysone-dependent, single-copy Drosophila gene, whose transcripts accumulate rapidly in imaginal discs in response to the hormone. The IMP-E2 product is secreted at...

journal_title：Developmental biology

authors： Paine-Saunders S,Fristrom D,Fristrom JW

更新日期：1990-08-01 00:00:00

abstract：:The changes in the intracellular pH (pHi) of sea urchin sperm associated with motility initiation and acrosome reaction were investigated using uptake of two different probes; 9-aminoacridine and methylamine, as a qualitative index. Sperm suspended in Na+-free sea water were immotile and able to concentrate these amin...

journal_title：Developmental biology

authors： Lee HC,Johnson C,Epel D

更新日期：1983-01-01 00:00:00

abstract：:Much of boundary formation during development remains to be understood, despite being a defining feature of many animal taxa. Axial patterning of Hydra, a member of the ancient phylum Cnidaria which diverged prior to the bilaterian radiation, involves a steady-state of production and loss of tissue, and is dependent o...

journal_title：Developmental biology

authors： López-Quintero JA,Torres GG,Neme R,Bosch TCG

更新日期：2020-02-15 00:00:00

abstract：:Smad4 is defined as the common-mediator Smad (co-Smad) required for transducing signals for all TGF-beta superfamily members. This paper describes two Smad4s in Xenopus: XSmad4alpha, which is probably the Xenopus orthologue of human Smad4, and a distinct family member, XSmad4beta, which differs primarily at the extrem...

journal_title：Developmental biology

authors： Howell M,Itoh F,Pierreux CE,Valgeirsdottir S,Itoh S,ten Dijke P,Hill CS

更新日期：1999-10-15 00:00:00

abstract：:Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a number of crucial signalling pathways during development. In this study, we report that DSulfatase-1 (DSulf1), the unique Drosophila Sulf prot...

journal_title：Developmental biology

authors： Wojcinski A,Nakato H,Soula C,Glise B

更新日期：2011-10-01 00:00:00

abstract：:The structure of the three polypeptide chains of the laminin subunits and the number of glycosylation sites in each polypeptide chain were determined using peptide mapping by high-performance liquid chromatography. Analysis of the [35S]methionine-labeled underglycosylated laminin isolated from tunicamycin (TM)-treated...

journal_title：Developmental biology

authors： Howe CC,Dietzschold B

更新日期：1983-08-01 00:00:00

abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...

journal_title：Developmental biology

authors： Carpenter EM,Hollyday M

更新日期：1992-03-01 00:00:00

abstract：:Mitogen-activated protein kinases (MAPKs) are important regulators of many cellular processes. In mammalian testes, these kinases are involved in controlling cell division, differentiation, survival and death, and are therefore critical to spermatogenesis. Recent studies have also illustrated their involvement in junc...

journal_title：Developmental biology

authors： Wong CH,Cheng CY

更新日期：2005-10-01 00:00:00

abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

journal_title：Developmental biology

authors： Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

更新日期：1984-09-01 00:00:00

abstract：:Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...

journal_title：Developmental biology

authors： Damianitsch K,Melchert J,Pieler T

更新日期：2009-05-15 00:00:00

abstract：:Intercellular communication mediated by gap junctions is important for tissue homeostasis in the avascular lens, and extensive areas of gap junctions form between fiber cells during fiber cell differentiation and lens development. We examined the role of the calcium-dependent cell adhesion molecule, N-cadherin, in the...

journal_title：Developmental biology

authors： Frenzel EM,Johnson RG

更新日期：1996-10-10 00:00:00

abstract：:HP1 proteins are essential components of heterochromatin and contribute to the transcriptional repression of euchromatic genes. Although most species contain more than one HP1 family member which differ in their chromosomal distribution, it is not known to what extent the activity of these different family members is ...

journal_title：Developmental biology

authors： Schott S,Coustham V,Simonet T,Bedet C,Palladino F

更新日期：2006-10-01 00:00:00