Caveolin-1 regulates dorsoventral patterning through direct interaction with beta-catenin in zebrafish.

Abstract:

:Caveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively regulates a number of cellular signaling events including canonical Wnt signaling. Activation of the Wnt/beta-catenin pathway is essential for dorsal organizer formation and specification in early vertebrate embryos, but it remains not well understood what controls dorsal activity of maternal beta-catenin and how Cav-1 functions in zebrafish embryogenesis. Here, we report that Cav-1 is required for proper dorsoventral patterning in zebrafish. Both Wnt and BMP signals act coordinately to negatively control transcriptional expression of cav-1 during embryonic development. Ectopic expression of Cav-1alpha or -1beta resulted in formation of typical ventralized embryos, whereas Cav-1 knockdown led to abnormal embryos with expanded expression of dorsal genes. Cav-1 overexpression disrupts the nuclear translocation of beta-catenin through the interaction of its scaffolding domain with Cav-1 binding motif of beta-catenin. This reciprocal interaction is necessary for the ventralizing activity of Cav-1. We have further demonstrated that human Cav-1 proteins have conserved ventralizing activity in zebrafish embryogenesis. Thus, maternally expressed zebrafish Cav-1 regulates dorsoventral patterning by limiting nuclear translocation of active beta-catenin.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Mo S,Wang L,Li Q,Li J,Li Y,Thannickal VJ,Cui Z

doi

10.1016/j.ydbio.2010.04.033

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

210-23

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(10)00286-1

journal_volume

344

pub_type

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