Localization and function of Bam protein require the benign gonial cell neoplasm gene product.

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00

abstract：:During chick limb development the gap junction protein Connexin-43 (Cx43) is expressed in discrete spatially restricted domains in the apical ectodermal ridge (AER) and mesenchyme of the zone of polarising activity. Antisense oligonucleotides (ODNs) were used to investigate the role of Connexin-43 (Cx43) in the develo...

journal_title：Developmental biology

authors： Makarenkova H,Patel K

更新日期：1999-03-15 00:00:00

abstract：:While Wnt signaling is known to be involved in early steps of neural crest development, the mechanism remains unclear. Because Wnt signaling is able to posteriorize anterior neural tissues, neural crest induction by Wnts has been proposed to be an indirect consequence of posteriorization of neural tissues rather than ...

journal_title：Developmental biology

authors： Wu J,Yang J,Klein PS

更新日期：2005-03-01 00:00:00

abstract：:We have used an in vitro model to investigate the relationship between cell proliferation, cell maturation, and intercellular junctional changes that are seen during normal liver development. Chick liver fragments of embryonic stages 21, 28, and 39 were grown in organ culture in Medium 199 with 10% bovine serum albumi...

journal_title：Developmental biology

authors： Meyer RA,Overton J

更新日期：1983-09-01 00:00:00

abstract：:Angiogenesis relies on specialized endothelial tip cells to extend toward guidance cues in order to direct growing blood vessels. Although many of the signaling pathways that control this directional endothelial sprouting are well known, the specific cellular mechanisms that mediate this process remain to be fully elu...

journal_title：Developmental biology

authors： Yang H,Fang L,Zhan R,Hegarty JM,Ren J,Hsiai TK,Gleeson JG,Miller YI,Trejo J,Chi NC

更新日期：2015-08-15 00:00:00

abstract：:In mouse sex differentiation, SRY promotes Sertoli cell differentiation via SOX9 action, resulting in testis formation. SRY/SOX9 also initiates various testis-specific morphogenic events including glycogenesis in pre-Sertoli cells, suggesting the importance of glucose storage for certain SRY/SOX9-downstream events in ...

journal_title：Developmental biology

authors： Matoba S,Hiramatsu R,Kanai-Azuma M,Tsunekawa N,Harikae K,Kawakami H,Kurohmaru M,Kanai Y

更新日期：2008-12-01 00:00:00

abstract：:To understand mechanisms of sex determination, it is important to know the lineage relationships of cells comprising the gonads. For example, in mice, the Y-linked gene Sry triggers differentiation of Sertoli cells from a cell population originating in the coelomic epithelium overlying the nascent gonad that also give...

journal_title：Developmental biology

authors： Sekido R,Lovell-Badge R

更新日期：2007-02-01 00:00:00

abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

journal_title：Developmental biology

authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

更新日期：2018-09-01 00:00:00

abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

journal_title：Developmental biology

authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

更新日期：2004-10-15 00:00:00

abstract：:The distribution of the extracellular matrix protein tenascin was studied in the developing chick visual system to determine its possible regulatory role in retinotectal development. Little tenascin was present in the retinal optic fiber layer, and the optic nerve and tract, but was abundant in the stratum opticum of ...

journal_title：Developmental biology

authors： Perez RG,Halfter W

更新日期：1993-03-01 00:00:00

abstract：:Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...

journal_title：Developmental biology

authors： DiMario JX,Stockdale FE

更新日期：1997-08-01 00:00:00

abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

journal_title：Developmental biology

authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

更新日期：1998-08-01 00:00:00

abstract：:Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1(tm1(cre)Skm)), in which the Foxg1 coding region was replaced by the Cre gene....

journal_title：Developmental biology

authors： Kawaguchi D,Sahara S,Zembrzycki A,O'Leary DDM

更新日期：2016-04-01 00:00:00

abstract：:Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

journal_title：Developmental biology

authors： Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

更新日期：2014-11-15 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...

journal_title：Developmental biology

authors： Kraus P,Sivakamasundari V,Lim SL,Xing X,Lipovich L,Lufkin T

更新日期：2013-04-15 00:00:00

abstract：:Somatic embryogenesis is one of the best examples of the remarkable developmental plasticity of plants, in which committed somatic cells can dedifferentiate and acquire the ability to form an embryo and regenerate an entire plant. In Arabidopsis thaliana, the shoot apices of young seedlings have been reported as an al...

journal_title：Developmental biology

authors： Kadokura S,Sugimoto K,Tarr P,Suzuki T,Matsunaga S

更新日期：2018-10-01 00:00:00

abstract：:Using lineage tracers, we recently showed dorsal and ventral ectodermal compartments along the sides of the body in chick embryos. The compartments are formed both in presumptive limb-forming regions where they position the apical ridge and also in presumptive interlimb (flank). Here we show, using a novel technique c...

journal_title：Developmental biology

authors： Altabef M,Logan C,Tickle C,Lumsden A

更新日期：2000-06-15 00:00:00

abstract：:Although communications between mammalian oocytes and their surrounding granulosa cells mediated by the Kit-Kit ligand (KL, or stem cell factor, SCF) system have been proven to be crucial for follicular development, Kit downstream signaling pathways in mammalian oocytes are largely unknown. In this study, by using ova...

journal_title：Developmental biology

authors： Reddy P,Shen L,Ren C,Boman K,Lundin E,Ottander U,Lindgren P,Liu YX,Sun QY,Liu K

更新日期：2005-05-15 00:00:00

abstract：:We have compared insulin binding by heart cells at 7 and 14 days of development. Species specificity, optimum pH, temperature relationships, and time to equilibrium for binding of insulin were the same in both 7 and 14-day systems. Curvilinear Scatchard plots for chicken insulin binding were demonstrated. Binding affi...

journal_title：Developmental biology

authors： Serravezza JC,Wheeler FB,DeHaan RL,Elsas LJ

更新日期：1981-06-01 00:00:00

abstract：:Initiation of transcription mediated by RNA polymerase II requires a number of transcription factors among which TFIID is the major core promoter recognition factor. TFIID is composed of highly conserved factors which include the TATA-binding protein (TBP) and about 14 TBP-associated factors (TAFs). Recently, the comp...

journal_title：Developmental biology

authors： Lago C,Clerici E,Dreni L,Horlow C,Caporali E,Colombo L,Kater MM

更新日期：2005-09-01 00:00:00

abstract：:Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the regulation of Pax6 pancreatic expression, we have identified a minimal Pax6 pancreatic enhancer and show that it contains a composite binding site for Meis and Pbx homeop...

journal_title：Developmental biology

authors： Zhang X,Rowan S,Yue Y,Heaney S,Pan Y,Brendolan A,Selleri L,Maas RL

更新日期：2006-12-15 00:00:00

abstract：:The protein content of various size follicles was measured in Fundulus heteroclitus and indicated four phases of increase relative to follicle volume: Phases I (previtellogenic; estimated to be less than 0.01 mg/mm3), II (vitellogenic; 0.20 mg/mm3), III (early maturation; 0.03 mg/mm3), and IV (late maturation; 0 mg/mm...

journal_title：Developmental biology

authors： Wallace RA,Selman K

更新日期：1985-08-01 00:00:00

abstract：:From July 19-24, 2015, 169 clinicians and basic scientists gathered in the vertiginous heights of Snowmass, Colorado (2502 m) for the fourth FASEB summer research conference on the 'Biology of Cilia and Flagella'. Organizers Maureen Barr (Rutgers University), Iain Drummond (Massachusetts General Hospital/Harvard Medic...

journal_title：Developmental biology

authors： Tran PV,Lechtreck KF

更新日期：2016-01-15 00:00:00

abstract：:The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...

journal_title：Developmental biology

authors： Grafi G

更新日期：2004-04-01 00:00:00

abstract：:Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with th...

journal_title：Developmental biology

authors： Suzuki D,Yamada A,Amano T,Yasuhara R,Kimura A,Sakahara M,Tsumaki N,Takeda S,Tamura M,Nakamura M,Wada N,Nohno T,Shiroishi T,Aiba A,Kamijo R

更新日期：2009-11-15 00:00:00

abstract：:NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian. CnNK-2 ex...

journal_title：Developmental biology

authors： Grens A,Gee L,Fisher DA,Bode HR

更新日期：1996-12-15 00:00:00

abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

journal_title：Developmental biology

authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

更新日期：2000-01-01 00:00:00

abstract：:MicroRNA attenuation of protein translation has emerged as an important regulator of mesenchymal cell differentiation into the osteoblast lineage. A compelling question is the extent to which miR biogenesis is obligatory for bone formation. Here we show conditional deletion of the Dicer enzyme in osteoprogenitors by C...

journal_title：Developmental biology

authors： Gaur T,Hussain S,Mudhasani R,Parulkar I,Colby JL,Frederick D,Kream BE,van Wijnen AJ,Stein JL,Stein GS,Jones SN,Lian JB

更新日期：2010-04-01 00:00:00

abstract：:Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechanism of action is unknown. The Translational Control Sequence (TCS) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activati...

journal_title：Developmental biology

authors： Charlesworth A,Yamamoto TM,Cook JM,Silva KD,Kotter CV,Carter GS,Holt JW,Lavender HF,MacNicol AM,Ying Wang Y,Wilczynska A

更新日期：2012-09-15 00:00:00

abstract：:The distribution and ontogeny of four neuropeptides in developing chick lumbosacral sensory and sympathetic ganglia were studied using immunohistochemical techniques. Antibodies to two of these peptides, substance P (SP) and calcitonin gene-related peptide (CGRP), stained small neurons in the medial part of the dorsal...

journal_title：Developmental biology

authors： New HV,Mudge AW

更新日期：1986-08-01 00:00:00