Abstract:
:Exposure of Xenopus animal pole explants to transforming growth factor beta 2 (TGF-beta 2) induced the sequential expression of muscle nicotinic acetylcholine receptor (AChRs) isoforms and their corresponding mRNAs in cells which normally give rise to ectoderm. Single channel recordings revealed two functional classes of receptors with properties similar to those expressed during normal development of skeletal muscle in vivo. The predominant class of receptors in all patches corresponded to those of embryonic myotomal muscle. Additional receptors resembling those of mature myotomal muscle were observed in older explants. Levels of transcripts encoding the embryonic and adult AChR subunit isoforms varied accordingly. TGF-beta 2 appears to initiate a developmental program of AChR gene expression which is similar to that found in normally developing muscle.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Reuer Q,Kullberg RW,Owens JLdoi
10.1006/dbio.1994.1318subject
Has Abstractpub_date
1994-11-01 00:00:00pages
323-30issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(84)71318-2journal_volume
166pub_type
杂志文章abstract::A number of genes encoding developmentally regulated mRNAs in the cellular slime mold, Dictyostelium discoideum, have been described. Many of these are regulated by cAMP. Analysis of the earliest time at which elevated levels of cAMP can induce the expression of these mRNAs reveals a more complex pattern of regulation...
journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
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journal_title:Developmental biology
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journal_title:Developmental biology
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doi:
更新日期:2002-10-15 00:00:00
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journal_title:Developmental biology
pub_type: 杂志文章
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journal_title:Developmental biology
pub_type: 杂志文章
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更新日期:1996-09-15 00:00:00
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journal_title:Developmental biology
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