Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.


:The direct flight muscles (DFMs) of Drosophila allow for the fine control of wing position necessary for flight. In DWnt-2 mutant flies, certain DFMs are either missing or fail to attach to the correct epithelial sites. Using a temperature-sensitive allele, we show that DWnt-2 activity is required only during pupation for correct DFM patterning. DWnt-2 is expressed in the epithelium of the wing hinge primordium during pupation. This expression is in the vicinity of the developing DFMs, as revealed by expression of the muscle founder cell-specific gene dumbfounded in DFM precursors. The observation that a gene necessary for embryonic founder cell function is expressed in the DFM precursors suggests that these cells may have a similar founder cell role. Although the expression pattern of DWnt-2 suggests that it could influence epithelial cells to differentiate into attachment sites for muscle, the expression of stripe, a transcription factor necessary for epithelial cells to adopt an attachment cell fate, is unaltered in the mutant. Ectopic expression of DWnt-2 in the wing hinge during pupation can also create defects in muscle patterning without alterations in stripe expression. We conclude that DWnt-2 promotes the correct patterning of DFMs through a mechanism that is independent of the attachment site differentiation initiated by stripe.


Dev Biol


Developmental biology


Kozopas KM,Nusse R




Has Abstract


2002-03-15 00:00:00














  • Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.

    abstract::Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

    更新日期:2004-06-15 00:00:00

  • Cellular heterogeneity during vertebrate skeletal muscle development.

    abstract::Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical ...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Biressi S,Molinaro M,Cossu G

    更新日期:2007-08-15 00:00:00

  • Hormonal control of gene amplification and transcription in the salivary gland chromosomes of Trichosia pubescens.

    abstract::Trichosia pubescens larvae were ligated at different prepupal developmental stages in order to investigate whether ecdysterone acts just as a trigger or whether its presence in the hemolymph is constantly necessary for the induction of the late puffs, in particular the DNA puffs. The larvae were ligated in the middle ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Amabis DC,Amabis JM

    更新日期:1984-03-01 00:00:00

  • Differential binding of oocyte-type and somatic-type 5S rRNA to TFIIIA and ribosomal protein L5 in Xenopus oocytes: specialization for storage versus mobilization.

    abstract::We studied the pathway of 5S ribosomal RNA (rRNA) during oogenesis in Xenopus from its storage in the cytoplasm to incorporation into ribosomes in the nucleus. Ribonucleoprotein particle (RNP) assembly assays reveal striking differences in the behavior of oocyte-type and somatic-type 5S rRNA after microinjection into ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Allison LA,North MT,Neville LA

    更新日期:1995-04-01 00:00:00

  • Jagged2: a serrate-like gene expressed during rat embryogenesis.

    abstract::DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shawber C,Boulter J,Lindsell CE,Weinmaster G

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  • The coupling of cyclic GMP and photopolarization of Pelvetia zygotes.

    abstract::Unidirectional blue light directs the rhizoid-thallus axis in the apolar zygotes of Fucus and Pelvetia. Here, it is shown that blue light (but not red light) increased cyclic GMP levels of Pelvetia zygotes by about a factor of 2. When the increase in cyclic GMP was blocked by a guanylyl cyclase inhibitor, photopolariz...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Robinson KR,Miller BJ

    更新日期:1997-07-01 00:00:00

  • PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant.

    abstract::Hedgehog (Hh) signaling is thought to occur in primary cilia, but the molecular basis of Gli2 and Gli3 activation by Hh signaling in cilia is unknown. Similarly, how ciliary gene mutations result in reduced Gli3 processing that generates a repressor is also not clear. Here we show that Hh signaling inhibits Gli2 and G...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Li J,Wang C,Wu C,Cao T,Xu G,Meng Q,Wang B

    更新日期:2017-09-01 00:00:00

  • Interactions between metaphase and interphase factors in heterokaryons produced by fusion of mouse oocytes and zygotes.

    abstract::The cytoplasmic factor responsible for chromosome condensation was introduced into mouse zygotes at different times after fertilization by fusion of the zygotes with metaphase I oocytes. In 72% of heterokaryons obtained after fusion of early zygotes (14-18 hr post-human chorionic gonadotrophin (HCG) with oocytes, the ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bałakier H,Masui Y

    更新日期:1986-09-01 00:00:00

  • An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta.

    abstract::Embryonic organizers are signaling centers that coordinate developmental events within an embryo. Localized to either an individual cell or group of cells, embryonic organizing activity induces the specification of other cells in the embryo and can influence formation of body axes. In the spiralian Capitella teleta, p...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lanza AR,Seaver EC

    更新日期:2018-03-01 00:00:00

  • p53-mediated germ cell quality control in spermatogenesis.

    abstract::Spontaneous germ cell death is a common cellular process in the mammalian testis, although the function of this process during spermatogenesis is unclear. An investigation was undertaken to determine whether p53 serves as a mechanism in germ cell quality control by causing spontaneous germ cell death. Using an annexin...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Yin Y,Stahl BC,DeWolf WC,Morgentaler A

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  • Coordinate and noncoordinate regulation of synaptic vesicle protein genes during embryonic development.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lou X,Bixby JL

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  • Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Liu K,Cheng L,Flesken-Nikitin A,Huang L,Nikitin AY,Pauli BU

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  • R11: a cis-regulatory node of the sea urchin embryo gene network that controls early expression of SpDelta in micromeres.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Revilla-i-Domingo R,Minokawa T,Davidson EH

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  • E-cadherin regulates the behavior and fate of epithelial stem cells and their progeny in the mouse incisor.

    abstract::Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, skin, and intestine. Although human tooth regeneration is limited, a number of animals have evolved continuously growing teeth that provide models of stem cell-based organ renewal. A well-studied model is the mouse incis...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Li CY,Cha W,Luder HU,Charles RP,McMahon M,Mitsiadis TA,Klein OD

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  • pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis.

    abstract::The pdx1 gene is essential for pancreatic organogenesis in humans and mice; pdx1 mutations have been identified in human diabetic patients. Specific inactivation of pdx1 in adult beta cells revealed that this gene is required for maintenance of mature beta cell function. In the following study, a Cre-lox strategy was ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Gannon M,Ables ET,Crawford L,Lowe D,Offield MF,Magnuson MA,Wright CV

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Yasuo H,Hudson C

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  • Synovial joint formation requires local Ext1 expression and heparan sulfate production in developing mouse embryo limbs and spine.

    abstract::Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

    journal_title:Developmental biology

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    authors: Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

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  • The embryonic ciliated band of the sea urchin, Strongylocentrotus purpuratus derives from both oral and aboral ectoderm.

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    journal_title:Developmental biology

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    authors: Cameron RA,Britten RJ,Davidson EH

    更新日期:1993-12-01 00:00:00

  • Proneural gene requirement for hair cell differentiation in the zebrafish lateral line.

    abstract::The lateral line system comprises an array of mechanosensory organs, the neuromasts, distributed over the body surface. Each neuromast consists of a patch of mechanosensory hair cells surrounded by support cells. We show that, in the zebrafish, two proneural genes are essential for differentiation of the hair cells, n...

    journal_title:Developmental biology

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    authors: Sarrazin AF,Villablanca EJ,Nuñez VA,Sandoval PC,Ghysen A,Allende ML

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  • The FgfrL1 receptor is required for development of slow muscle fibers.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Amann R,Wyder S,Slavotinek AM,Trueb B

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  • A gradient of gap junctional communication along the anterior-posterior axis of the developing chick limb bud.

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    journal_title:Developmental biology

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    authors: Coelho CN,Kosher RA

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  • Fusion of fibroblasts with differentiated and nondifferentiated leukemia cells resulting in blockage of DNA synthesis.

    abstract::We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Prudovsky IA,Tsong TY

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  • C. elegans BED domain transcription factor BED-3 controls lineage-specific cell proliferation during organogenesis.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Inoue T,Sternberg PW

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  • Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rohith BN,Shyamala BV

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lange S,Gögel S,Leung KY,Vernay B,Nicholas AP,Causey CP,Thompson PR,Greene ND,Ferretti P

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sariola H,Ekblom P,Lehtonen E,Saxén L

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  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract::Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

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    abstract::Formation of the adenohypophysis in mammalian embryos occurs via an invagination of the oral ectoderm to form Rathke's pouch, which becomes exposed to opposing dorsoventral gradients of signaling proteins governing specification of the different hormone-producing pituitary cell types. One signal promoting pituitary ce...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Herzog W,Zeng X,Lele Z,Sonntag C,Ting JW,Chang CY,Hammerschmidt M

    更新日期:2003-02-01 00:00:00

  • Species-specific developmental timing is maintained by pluripotent stem cells ex utero.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Barry C,Schmitz MT,Jiang P,Schwartz MP,Duffin BM,Swanson S,Bacher R,Bolin JM,Elwell AL,McIntosh BE,Stewart R,Thomson JA

    更新日期:2017-03-15 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Eyal-Giladi H,Khaner O

    更新日期:1989-07-01 00:00:00