Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.

abstract：:Despite undergoing normal development and acquiring normal morphology and motility, mutations in spe-38 or trp-3/spe-41 cause identical phenotypes in Caenorhabditis elegans-mutant sperm fail to fertilize oocytes despite direct contact. SPE-38 is a novel, four-pass transmembrane protein and TRP-3/SPE-41 is a Ca(2+)-per...

journal_title：Developmental biology

authors： Singaravelu G,Chatterjee I,Rahimi S,Druzhinina MK,Kang L,Xu XZ,Singson A

更新日期：2012-05-15 00:00:00

abstract：:The development of supernumerary bristle precursors induced by the mutation shaggy (sgg; also known as zeste-white 3) was examined in the developing wing blade of imaginal and pupal Drosophila. sgg clones were induced by mitotic recombination; clones were marked using enhancer-trap flies which express beta-galactosida...

journal_title：Developmental biology

authors： Blair SS

更新日期：1992-08-01 00:00:00

abstract：:Ligands of the transforming growth factor beta (TGFbeta) superfamily, like Nodal and bone morphogenetic protein (BMP), are pivotal to establish left-right (LR) asymmetry in vertebrates. However, the receptors mediating this process are unknown. Here we identified two new type II receptors for BMPs in zebrafish termed ...

journal_title：Developmental biology

authors： Monteiro R,van Dinther M,Bakkers J,Wilkinson R,Patient R,ten Dijke P,Mummery C

更新日期：2008-03-01 00:00:00

abstract：:Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

journal_title：Developmental biology

authors： Li J,Rao H,Burkin D,Kaufman SJ,Wu C

更新日期：2003-09-01 00:00:00

abstract：:The correct assembly of junction components, such as E-cadherin and beta-catenin, into the zonula adherens is fundamental for the function of epithelia, both in flies and in vertebrates. In C. elegans, however, the cadherin-catenin system is not essential for general adhesion, raising the question as to the genetic ba...

journal_title：Developmental biology

authors： Bossinger O,Klebes A,Segbert C,Theres C,Knust E

更新日期：2001-02-01 00:00:00

abstract：:The categorical data set is an important data class in experimental biology and contains data separable into several mutually exclusive categories. Unlike measurement of a continuous variable, categorical data cannot be analyzed with methods such as the Student's t-test. Thus, these data require a different method of ...

journal_title：Developmental biology

authors： Xu B,Feng X,Burdine RD

更新日期：2010-12-01 00:00:00

abstract：:Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cel...

journal_title：Developmental biology

authors： Mohlin S,Kunttas E,Persson CU,Abdel-Haq R,Castillo A,Murko C,Bronner ME,Kerosuo L

更新日期：2019-03-15 00:00:00

abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

journal_title：Developmental biology

authors： Huang S,Guo YP,May G,Enver T

更新日期：2007-05-15 00:00:00

abstract：:The segregation of founder cells from the somatic mesoderm is a prerequisite for the formation of body wall muscles in the Drosophila embryo. The myogenic basic helix-loop-helix protein, Nautilus (Nau), is expressed in a subset of these founder cells in medial and lateral positions in the somatic mesoderm. Mutations i...

journal_title：Developmental biology

authors： Ranganayakulu G,Schulz RA,Olson EN

更新日期：1996-05-25 00:00:00

abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...

journal_title：Developmental biology

authors： Carlantoni C,Allanki S,Kontarakis Z,Rossi A,Piesker J,Günther S,Stainier DYR

更新日期：2021-01-01 00:00:00

abstract：:Syndecan-3 is one of four identified members of a family of transmembrane proteoglycans (the syndecans) that possess highly similar cytoplasmic and transmembrane domains and may function as extracellular matrix receptors and/or low affinity receptors for signaling molecules such as FGF. We previously reported the clon...

journal_title：Developmental biology

authors： Gould SE,Upholt WB,Kosher RA

更新日期：1995-04-01 00:00:00

abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

journal_title：Developmental biology

authors： Dasgupta K,Chung JU,Asam K,Jeong J

更新日期：2019-11-15 00:00:00

abstract：:Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not presen...

journal_title：Developmental biology

authors： Andersson O,Reissmann E,Jörnvall H,Ibáñez CF

更新日期：2006-05-15 00:00:00

abstract：:A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The do...

journal_title：Developmental biology

authors： Yorimitsu T,Kiritooshi N,Nakagoshi H

更新日期：2011-08-15 00:00:00

abstract：:During anuran metamorphosis, larval-type myotubes in both trunk and tail are removed by apoptosis, and only trunk muscles are replaced by newly formed adult-type myotubes. In the present study, we clarified the regulatory mechanisms for specific developmental fates of adult and larval muscles. Two distinct (adult and ...

journal_title：Developmental biology

authors： Shimizu-Nishikawa K,Shibota Y,Takei A,Kuroda M,Nishikawa A

更新日期：2002-11-01 00:00:00

abstract：:The nuclear receptor SpCOUP-TF is the highly conserved sea urchin homologue of the COUP family of transcription factors. Previous results from our laboratory demonstrated that SpCOUP-TF transcripts are localized in the egg and asymmetrically distributed in the early embryonic blastomeres (A. Vlahou et al., 1996, Devel...

journal_title：Developmental biology

authors： Vlahou A,Flytzanis CN

更新日期：2000-02-15 00:00:00

abstract：:Activation and role of mitogen-activated protein (MAP) kinase (MAPK) during mitosis are still matters of controversy in early embryos. We report here that an ERK-like protein is present and highly phosphorylated in unfertilized sea urchin eggs. This MAPK becomes dephosphorylated after fertilization and a small pool of...

journal_title：Developmental biology

authors： Zhang WL,Huitorel P,Glass R,Fernandez-Serra M,Arnone MI,Chiri S,Picard A,Ciapa B

更新日期：2005-06-01 00:00:00

abstract：:The propagation of pluripotential mouse embryonic stem (ES) cells is sustained by leukemia inhibitory factor (LIF) or related cytokines that act through a common receptor complex comprising the LIF receptor subunit (LIF-R) and the signal transducer gp130. However, the findings that embryos lacking LIF-R or gp130 can d...

journal_title：Developmental biology

authors： Dani C,Chambers I,Johnstone S,Robertson M,Ebrahimi B,Saito M,Taga T,Li M,Burdon T,Nichols J,Smith A

更新日期：1998-11-01 00:00:00

abstract：:The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...

journal_title：Developmental biology

authors： Jena MK,Jaswal S,Kumar S,Mohanty AK

更新日期：2019-01-15 00:00:00

abstract：:TGF-beta superfamily members signal through a heteromeric receptor complex to regulate craniofacial development. TGF-beta type II receptor appears to bind only TGF-beta, whereas TGF-beta type I receptor (ALK5) also binds to ligands in addition to TGF-beta. Our previous work has shown that conditional inactivation of T...

journal_title：Developmental biology

authors： Zhao H,Oka K,Bringas P,Kaartinen V,Chai Y

更新日期：2008-08-01 00:00:00

abstract：:Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

journal_title：Developmental biology

authors： Mason-Suares H,Tie F,Yan CM,Harte PJ

更新日期：2013-08-01 00:00:00

abstract：:A polarity in gap junctional permeability normally exists in 32-cell stage Xenopus embryos, in that dorsal cells are relatively more coupled than ventral cells, as measured by transfer of Lucifer yellow dye. The current study extends our analysis of whether gap junctional permeability at this stage can be modulated by...

journal_title：Developmental biology

authors： Olson DJ,Moon RT

更新日期：1992-05-01 00:00:00

abstract：:The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

journal_title：Developmental biology

authors： Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

更新日期：2014-09-15 00:00:00

abstract：:Sex in the nematode Caenorhabditis elegans is normally determined by the X chromosome to autosome (X:A) ratio, with XX hermaphrodites and XO males. Previous work has shown that a set of at least four autosomal genes (her-1, tra-2, tra-3, and tra-1) is signaled by the X:A ratio and appears to act in a regulatory pathwa...

journal_title：Developmental biology

authors： Doniach T,Hodgkin J

更新日期：1984-11-01 00:00:00

abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

journal_title：Developmental biology

authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

更新日期：1999-04-15 00:00:00

abstract：:The murine homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during mouse embryogenesis. We now report the developmentally regulated expression of Msx-1 and Msx-2 in the mouse mammary gland and show that their expression patterns point toward significant fu...

journal_title：Developmental biology

authors： Friedmann Y,Daniel CW

更新日期：1996-07-10 00:00:00

abstract：:Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...

journal_title：Developmental biology

authors： Palmieri SL,Peter W,Hess H,Schöler HR

更新日期：1994-11-01 00:00:00

abstract：:Lens growth involves the proliferation of epithelial cells, followed by their migration to the equator region and differentiation into secondary fiber cells. It is widely accepted that fibroblast growth factor (FGF) signaling is required for the differentiation of lens epithelial cells into crystallin-rich fibers, but...

journal_title：Developmental biology

authors： Song X,Sato Y,Felemban A,Ito A,Hossain M,Ochiai H,Yamamoto T,Sekiguchi K,Tanaka H,Ohta K

更新日期：2012-08-01 00:00:00

abstract：:Extracellular modulators of cell-cell signaling control numerous aspects of organismal development. The Twisted gastrulation (Twsg1) gene product is a small, secreted cysteine-rich protein that has the unusual property of being able to either enhance or inhibit signaling by the bone morphogenetic protein (BMP) subfami...

journal_title：Developmental biology

authors： Petryk A,Anderson RM,Jarcho MP,Leaf I,Carlson CS,Klingensmith J,Shawlot W,O'Connor MB

更新日期：2004-03-15 00:00:00

abstract：:Male germline stem cells (GSCs) in Drosophila melanogaster divide asymmetrically by orienting the mitotic spindle with respect to the niche, a microenvironment that specifies stem cell identity. The spindle orientation is prepared during interphase through stereotypical positioning of the centrosomes. We recently demo...

journal_title：Developmental biology

authors： Yuan H,Chiang CY,Cheng J,Salzmann V,Yamashita YM

更新日期：2012-01-01 00:00:00