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Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.

Abstract：

:In tetrapods, the anteroposterior (AP) patterning of the limb is under the control of the antagonistic activities of the secreted factor Sonic hedgehog (Shh) and Gli3R, the truncated repressor form of the transcription factor Gli3. In this report, we show that Msx1 and Msx2 are targets and downstream effectors of Gli3R. Consequently, in Shh null mutants, Msx genes are overexpressed and, furthermore, partially responsible for the limb phenotype. This is exemplified by the fact that reducing Msx activity in Shh mutants partially restores a normal limb development. Finally, we show that the main action of the Msx genes, in both normal and Shh(-/-) limb development, is to control cell death in the mesenchyme. We propose that, in the limb, Msx genes act downstream of the Shh/Gli3 pathway by transducing BMP signaling and that, in the absence of Shh signaling, their deregulation contributes to the extensive apoptosis that impairs limb development.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Lallemand Y,Bensoussan V,Cloment CS,Robert B

doi

10.1016/j.ydbio.2009.04.038

subject

Has Abstract

pub_date

2009-07-15 00:00:00

pages

189-98

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(09)00300-5

journal_volume

331

pub_type

杂志文章

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