Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb.

abstract：:The genetic and developmental bases for trait expression and variation in adults are largely unknown. One system in which genes and cell behaviors underlying adult traits can be elucidated is the larval-to-adult transformation of zebrafish, Danio rerio. Metamorphosis in this and many other teleost fishes resembles amp...

journal_title：Developmental biology

authors： Parichy DM,Turner JM

更新日期：2003-04-15 00:00:00

abstract：:Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. KDM4A demeth...

journal_title：Developmental biology

authors： Crona F,Dahlberg O,Lundberg LE,Larsson J,Mannervik M

更新日期：2013-01-15 00:00:00

abstract：:The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1986-05-01 00:00:00

abstract：:Using lineage tracers, we recently showed dorsal and ventral ectodermal compartments along the sides of the body in chick embryos. The compartments are formed both in presumptive limb-forming regions where they position the apical ridge and also in presumptive interlimb (flank). Here we show, using a novel technique c...

journal_title：Developmental biology

authors： Altabef M,Logan C,Tickle C,Lumsden A

更新日期：2000-06-15 00:00:00

abstract：:Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due t...

journal_title：Developmental biology

authors： Xia Z,Tong X,Liang F,Zhang Y,Kuok C,Zhang Y,Liu X,Zhu Z,Lin S,Zhang B

更新日期：2013-09-01 00:00:00

abstract：:An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...

journal_title：Developmental biology

authors： Litvin J,Montgomery MO,Goldhamer DJ,Emerson CP Jr,Bader DM

更新日期：1993-04-01 00:00:00

abstract：:Kinesin light chain 3 (KLC3) is the only known kinesin light chain expressed in post-meiotic male germ cells. We have reported that in rat spermatids KLC3 associates with outer dense fibers and mitochondrial sheath. KLC3 is able to bind to mitochondria in vitro and in vivo employing the conserved tetratrico-peptide re...

journal_title：Developmental biology

authors： Zhang Y,Ou Y,Cheng M,Saadi HS,Thundathil JC,van der Hoorn FA

更新日期：2012-06-15 00:00:00

abstract：:Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...

journal_title：Developmental biology

authors： Grainger S,Lam J,Savory JG,Mears AJ,Rijli FM,Lohnes D

更新日期：2012-01-01 00:00:00

abstract：:Canonical Wnt signalling is known to be involved in the regulation of differentiation and proliferation in the context of endodermal organogenesis. Wnt mediated beta-catenin activation is understood to be modulated by secreted Frizzled-related proteins, such as XsFRP5, which is dynamically expressed in the prospective...

journal_title：Developmental biology

authors： Damianitsch K,Melchert J,Pieler T

更新日期：2009-05-15 00:00:00

abstract：:The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

journal_title：Developmental biology

authors： Pennimpede T,Cameron DA,MacLean GA,Petkovich M

更新日期：2010-03-01 00:00:00

abstract：:Previous studies in sea urchin embryos have demonstrated that nuclearization of beta-catenin is essential for initial steps in the specification of endoderm and mesenchyme, which are derived from vegetal blastomeres. This process begins at the 4th and extends through the 9th cleavage stage, an interval in which the Sp...

journal_title：Developmental biology

authors： Kenny AP,Oleksyn DW,Newman LA,Angerer RC,Angerer LM

更新日期：2003-09-15 00:00:00

abstract：:During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

journal_title：Developmental biology

authors： Moss SB,Challoner PB,Groudine M

更新日期：1989-05-01 00:00:00

abstract：:Rex1 (Zfp42), GeneID 132625, is a gene whose expression is closely associated with pluripotency/multipotency in both mouse and human embryonic stem cells. To study the function of the murine Rex1 gene in vivo, we have used cre/lox technology to create Rex1(floxed) mice and mice deficient in Rex1 gene function. Rex1(-/...

journal_title：Developmental biology

authors： Rezende NC,Lee MY,Monette S,Mark W,Lu A,Gudas LJ

更新日期：2011-08-15 00:00:00

abstract：:Drosophila melanogaster mature oocytes in ovaries are arrested at metaphase I of meiosis. Eggs that have reached the uterus have released this arrest. It was not known where in the female reproductive tract egg activation occurs and what triggers it. We investigated when and where the egg is activated in Drosophila in...

journal_title：Developmental biology

authors： Heifetz Y,Yu J,Wolfner MF

更新日期：2001-06-15 00:00:00

abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

journal_title：Developmental biology

authors： Madireddi MT,Davis MC,Allis CD

更新日期：1994-10-01 00:00:00

abstract：:The nuclear receptor SpCOUP-TF is the highly conserved sea urchin homologue of the COUP family of transcription factors. Previous results from our laboratory demonstrated that SpCOUP-TF transcripts are localized in the egg and asymmetrically distributed in the early embryonic blastomeres (A. Vlahou et al., 1996, Devel...

journal_title：Developmental biology

authors： Vlahou A,Flytzanis CN

更新日期：2000-02-15 00:00:00

abstract：:Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...

journal_title：Developmental biology

authors： Kosher RA,Solursh M

更新日期：1989-02-01 00:00:00

abstract：:We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...

journal_title：Developmental biology

authors： Santella L,Monroy A,Rosati F

更新日期：1983-10-01 00:00:00

abstract：:Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, even in model organisms such as Drosophila melanogaster, is only recently being reve...

journal_title：Developmental biology

authors： Franke JD,Montague RA,Kiehart DP

更新日期：2010-09-15 00:00:00

abstract：:The Toll signaling pathway functions in several Drosophila processes, including dorsal-ventral pattern formation and the immune response. Here, we demonstrate that this pathway is required in the epidermis for proper muscle development. Previously, we showed that the zygotic Toll protein is necessary for normal muscle...

journal_title：Developmental biology

authors： Halfon MS,Keshishian H

更新日期：1998-07-01 00:00:00

abstract：:Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...

journal_title：Developmental biology

authors： Li J,Kim T,Szymanski DB

更新日期：2019-07-01 00:00:00

abstract：:Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...

journal_title：Developmental biology

authors： Gaboriau D,Howes EA,Clark J,Jones R

更新日期：2007-06-15 00:00:00

abstract：:Mouse mammary ductal cells cultured in type I collagen gels give rise to three-dimensional multicellular outgrowths consisting of thin spikes which are often branched, and which may have pointed or blunt ends. The significance of these spikes to normal ductal morphogenesis has been unclear, since identical structures ...

journal_title：Developmental biology

authors： Daniel CW,Berger JJ,Strickland P,Garcia R

更新日期：1984-07-01 00:00:00

abstract：:A cDNA library was used to measure changes in many individual mRNAs during muscle differentiation in culture. A library of 1000 clones was constructed from total myofiber poly(A) RNA. About 23% of these clones gave a detectable colony hybridization signal using end-labeled myofiber mRNA, the remainder containing muscl...

journal_title：Developmental biology

authors： Devlin RB,Haskell SG

更新日期：1983-02-01 00:00:00

abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

journal_title：Developmental biology

authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

更新日期：2000-11-15 00:00:00

abstract：:The Mesp bHLH genes play a conserved role during segmental patterning of the mesoderm in the vertebrate embryo by specifying segmental boundaries and anteroposterior (A-P) segmental polarity. Here we use a xenotransgenic approach to compare the transcriptional enhancers that drive expression of the Mesp genes within s...

journal_title：Developmental biology

authors： Moreno TA,Jappelli R,Izpisúa Belmonte JC,Kintner C

更新日期：2008-03-15 00:00:00

abstract：:The primary lung bud originates from the foregut and develops into the bronchial tree by repetitive branching and outgrowing of the airway. The Sry related HMG box protein Sox2 is expressed in a cyclic manner during initiation and branching morphogenesis of the lung. It is highly expressed in non-branching regions and...

journal_title：Developmental biology

authors： Gontan C,de Munck A,Vermeij M,Grosveld F,Tibboel D,Rottier R

更新日期：2008-05-01 00:00:00

abstract：:Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

journal_title：Developmental biology

authors： Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

更新日期：2007-01-15 00:00:00

abstract：:Hedgehog proteins have been implicated in the control of myogenesis in the medial vertebrate somite. In the mouse, normal epaxial expression of the myogenic transcription factor gene myf5 is dependent on Sonic hedgehog. Here we examine in zebrafish the interaction between Hedgehog signals, the expression of myoD famil...

journal_title：Developmental biology

authors： Coutelle O,Blagden CS,Hampson R,Halai C,Rigby PW,Hughes SM

更新日期：2001-08-01 00:00:00

abstract：:Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and ...

journal_title：Developmental biology

authors： O'Keefe DD,Prober DA,Moyle PS,Rickoll WL,Edgar BA

更新日期：2007-11-01 00:00:00