Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

abstract：:To investigate the molecular regulation of embryonic somite formation and development, we have cloned the full-length cDNA and characterized the embryonic expression profile of chicken Paraxis, a member of a novel family of basic helix-loop-helix (bHLH) proteins, which has been suggested to play a role in paraxial mes...

journal_title：Developmental biology

authors： Barnes GL,Alexander PG,Hsu CW,Mariani BD,Tuan RS

更新日期：1997-09-01 00:00:00

abstract：:T-box family transcription factors play many roles in Metazoan development. Here we characterise Tbx6r, a unique Tbx6 paralogue isolated from the amphibian Xenopus. The evolution and developmental integration of this divergent T-box gene within the vertebrates reveals an unexpected level of plasticity within this cons...

journal_title：Developmental biology

authors： Callery EM,Thomsen GH,Smith JC

更新日期：2010-04-01 00:00:00

abstract：:The ubiquitin-proteasome system is essential for intracellular protein degradation, but there are few studies of this system in the extracellular milieu. Recently, we reported that a 70-kDa sperm receptor, HrVC70, on the vitelline coat is ubiquitinated and then degraded by the sperm proteasome during fertilization of ...

journal_title：Developmental biology

authors： Sakai N,Sawada H,Yokosawa H

更新日期：2003-12-01 00:00:00

abstract：:Rex1 (Zfp42), GeneID 132625, is a gene whose expression is closely associated with pluripotency/multipotency in both mouse and human embryonic stem cells. To study the function of the murine Rex1 gene in vivo, we have used cre/lox technology to create Rex1(floxed) mice and mice deficient in Rex1 gene function. Rex1(-/...

journal_title：Developmental biology

authors： Rezende NC,Lee MY,Monette S,Mark W,Lu A,Gudas LJ

更新日期：2011-08-15 00:00:00

abstract：:The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...

journal_title：Developmental biology

authors： Yamada R,Mizutani-Koseki Y,Koseki H,Takahashi N

更新日期：2004-10-15 00:00:00

abstract：:Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is expressed in mesenchymal cells that associate with the vascular endothelium....

journal_title：Developmental biology

authors： Whitesell TR,Chrystal PW,Ryu JR,Munsie N,Grosse A,French CR,Workentine ML,Li R,Zhu LJ,Waskiewicz A,Lehmann OJ,Lawson ND,Childs SJ

更新日期：2019-09-01 00:00:00

abstract：:The germ-line cells of many animals possess a characteristic cytoplasmic structure termed nuage or germinal granules. In mice, nuage that is prominent in postnatal male germ cells is also called intermitochondrial cement or chromatoid bodies. TDRD1/MTR-1, which contains Tudor domain repeats, is a specific component of...

journal_title：Developmental biology

authors： Hosokawa M,Shoji M,Kitamura K,Tanaka T,Noce T,Chuma S,Nakatsuji N

更新日期：2007-01-01 00:00:00

abstract：:Although local epithelial-mesenchymal tissue interactions which are presumably mediated by extracellular matrix molecules are important regulators of tooth morphogenesis and differentiation, our studies have indicated that these developmental processes also depend on circulating molecules. The iron-carrying serum prot...

journal_title：Developmental biology

authors： Partanen AM,Ekblom P,Thesleff I

更新日期：1985-09-01 00:00:00

abstract：:The experimental manipulation of early embryologic events, resulting in the misexpression of the homeobox transcription factor pitx2, is associated with subsequent defects of laterality in a number of vertebrate systems. To clarify the role of one pitx2 isoform, pitx2c, in determining the left-right axis of amphibian ...

journal_title：Developmental biology

authors： Dagle JM,Sabel JL,Littig JL,Sutherland LB,Kolker SJ,Weeks DL

更新日期：2003-10-15 00:00:00

abstract：:POSH (Plenty of SH3s) has distinct roles as a scaffold for specific c-Jun N-terminal kinase (JNK) signaling modules and as an E3 ubiquitin ligase. The physiological function of POSH remains unclear, however, and its possible involvement in developmental processes motivated the present study wherein the Xenopus ortholo...

journal_title：Developmental biology

authors： Kim GH,Park E,Han JK

更新日期：2005-10-01 00:00:00

abstract：:The mammillary body, a ventral specialization of the caudal hypothalamus, lies close to the transition between epichordal and prechordal parts of the forebrain (Puelles and Rubenstein, 2003). This report examines its presumed causal connection with either prechordal or notochordal mesodermal induction, as well as the ...

journal_title：Developmental biology

authors： García-Calero E,Fernández-Garre P,Martínez S,Puelles L

更新日期：2008-08-15 00:00:00

abstract：:Conjugation in Tetrahymena represents an ordered developmental pathway which represents the sexual phase of the ciliate life cycle. This pathway is initiated when starved cells of opposite mating types are mixed and are allowed to make a series of cell-cell contacts (a period termed costimulation) which lead to the fo...

journal_title：Developmental biology

authors： Schulman IG,Wang TT,Stargell LA,Gorovsky MA,Allis CD

更新日期：1991-02-01 00:00:00

abstract：:The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...

journal_title：Developmental biology

authors： Thomsen MK,Butler CM,Shen MM,Swain A

更新日期：2008-04-15 00:00:00

abstract：:We investigated whether the inhibition of proteoglycan synthesis and salivary branching morphogenesis by beta-D-xyloside was related to the deposition and processing of newly synthesized glycosaminoglycans at the basal epithelial surface that correlates with normal branching activity. Forty eight-hour cultures of cont...

journal_title：Developmental biology

authors： Spooner BS,Bassett K,Stokes B

更新日期：1985-05-01 00:00:00

abstract：:Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohis...

journal_title：Developmental biology

authors： Sallin P,de Preux Charles AS,Duruz V,Pfefferli C,Jaźwińska A

更新日期：2015-03-01 00:00:00

abstract：:We have isolated Xbr-1, a novel Xenopus homeobox gene that defines a new class of homeobox genes, distantly related to the Drosophila BarH1 and BarH2 genes. Xbr-1 is predominantly expressed in the developing Xenopus eye, starting as early as the neural plate stage. At early stages of eye development XBR-1 is expressed...

journal_title：Developmental biology

authors： Papalopulu N,Kintner C

更新日期：1996-02-25 00:00:00

abstract：:Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...

journal_title：Developmental biology

authors： Shimada IS,Somatilaka BN,Hwang SH,Anderson AG,Shelton JM,Rajaram V,Konopka G,Mukhopadhyay S

更新日期：2019-06-01 00:00:00

abstract：:Retinoic acid (RA) is a potent inducer of cell differentiation and plays an essential role in sex-specific germ cell development in the mammalian gonad. RA is essential for male gametogenesis and hence fertility. However, RA can also disrupt sexual cell fate in somatic cells of the testis, promoting transdifferentiati...

journal_title：Developmental biology

authors： Minkina A,Lindeman RE,Gearhart MD,Chassot AA,Chaboissier MC,Ghyselinck NB,Bardwell VJ,Zarkower D

更新日期：2017-04-15 00:00:00

abstract：:The unfertilized oocyte contains various granules which serve as storage sites for proteins, the majority which are yolk granules or platelets. Yolk granules are thought to provide the developing embryo with nutrients essential for its survival, while other granules contain proteins such as enzymes and extracellular m...

journal_title：Developmental biology

authors： Reimer CL,Crawford BJ

更新日期：1995-02-01 00:00:00

abstract：:A simple assay has been developed to measure cGMP-specific phosphodiesterase (cGPD) activity in crude soluble extracts of amoebae of Dictyostelium discoideum. When amoebae of different wild-type strains were starved on buffered agar, all strains exhibited an 8- to 12-fold increase in cGMP-specific hydrolyzing activity...

journal_title：Developmental biology

authors： Coukell MB,Cameron AM,Pitre CM,Mee JD

更新日期：1984-05-01 00:00:00

abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

journal_title：Developmental biology

authors： Dupin E

更新日期：1984-10-01 00:00:00

abstract：:We have compared the ability of uncapacitated, capacitated acrosome intact, and acrosome-reacted hamster sperm to penetrate the cumulus and corona radiata of fresh hamster oocyte-cumulus complexes (OCC) in vitro. This was done using physiological numbers (1-20) of sperm so that cumulus and corona radiata cells did not...

journal_title：Developmental biology

authors： Corselli J,Talbot P

更新日期：1987-07-01 00:00:00

abstract：:Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

journal_title：Developmental biology

authors： Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

更新日期：2014-11-15 00:00:00

abstract：:Cardiomyocyte differentiation overall has been analyzed in vivo and in vitro at the molecular level by homologous recombination, gene mutation studies, and by transgenics; however, the roles of many signal transduction mechanisms that drive this differentiation process are still not fully understood. One set of signal...

journal_title：Developmental biology

authors： Zhou X,Quann E,Gallicano GI

更新日期：2003-03-15 00:00:00

abstract：:The cDNA encoding the TATA binding protein was isolated from 8- to 16-cell and morula-stage embryonic libraries of two distantly related species of sea urchin, Strongylocentrotus purpuratus and Lytechinus variegatus, respectively. The two proteins are 96% identical over both the N- and C-terminal domains, suggesting a...

journal_title：Developmental biology

authors： Edelmann L,Zheng L,Wang ZF,Marzluff W,Wessel GM,Childs G

更新日期：1998-12-01 00:00:00

abstract：:About 12-17% of the embryos obtained by mating mice carrying the In(X)1H or Paf mutations are of the 39,X (X0) genotype. Depending on the mutant mice used for mating, the monosomic X chromosome can be inherited from the paternal (XP) or the maternal (XM) parent. The XP0 embryos display developmental retardation at gas...

journal_title：Developmental biology

authors： Jamieson RV,Tan SS,Tam PP

更新日期：1998-09-01 00:00:00

abstract：:Vimentin expression in the lens is striking due to the reported mesenchymal preference of vimentin and the epithelial origin of the lens. The amount of chicken vimentin mRNA levels determined by Northern blot analysis increased 3-fold from 7 to 14 days of embryonic lens development and then decreased 10-fold at 16 day...

journal_title：Developmental biology

authors： Sax CM,Farrell FX,Zehner ZE,Piatigorsky J

更新日期：1990-05-01 00:00:00

abstract：:Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate sa...

journal_title：Developmental biology

authors： Berberoglu MA,Gallagher TL,Morrow ZT,Talbot JC,Hromowyk KJ,Tenente IM,Langenau DM,Amacher SL

更新日期：2017-04-15 00:00:00

abstract：:The commitment and differentiation of the alveolar type I (AT1) cell lineage is a critical step for the formation of distal lung saccules, which are the primitive alveolar units required for postnatal respiration. How AT1 cells arise from the distal lung epithelial progenitor cells prior to birth and whether this proc...

journal_title：Developmental biology

authors： Wang X,Wang Y,Snitow ME,Stewart KM,Li S,Lu M,Morrisey EE

更新日期：2016-06-15 00:00:00

abstract：:Oligodendrocytes are produced from the same region of the ventral spinal cord that earlier generated motor neurons in bird and rodent embryos. Motor neuron and oligodendrocyte precursor cells express Olig genes, which encode basic helix-loop-helix transcription factors that play important roles in the development of b...

journal_title：Developmental biology

authors： Park HC,Mehta A,Richardson JS,Appel B

更新日期：2002-08-15 00:00:00