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Interactions between metaphase and interphase factors in heterokaryons produced by fusion of mouse oocytes and zygotes.

Abstract：

:The cytoplasmic factor responsible for chromosome condensation was introduced into mouse zygotes at different times after fertilization by fusion of the zygotes with metaphase I oocytes. In 72% of heterokaryons obtained after fusion of early zygotes (14-18 hr post-human chorionic gonadotrophin (HCG) with oocytes, the male and female pronuclei of the zygote decondensed. At the same time, the oocyte chromosomes became enclosed in a nuclear envelope and decondensed to an interphase state. However, in the rest of the heterokaryons, the chromatin of the pronuclei condensed to metaphase chromosomes, thus resulting in three sets of chromosomes. Fusion of zygotes that had begun DNA synthesis (20-22 hr post-HCG) with oocytes induced chromosome condensation of the pronuclei in 76% of the cases. In some heterokaryons, however, the oocyte chromosome decondensed to an interphase state similar to the zygote pronuclei. Fusion between late zygotes (27-29 hr post-HCG) with oocytes resulted in chromosome condensation of the pronuclei in all heterokaryons. On the basis of these results, the formation of the pronuclei and their progression toward mitosis in the zygote may be explained by changing levels of a metaphase factor in the cell, or by a balance between interphase and metaphase factors.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Bałakier H,Masui Y

doi

10.1016/0012-1606(86)90352-0

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

102-8

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(86)90352-0

journal_volume

117

pub_type

杂志文章

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