Abstract：
:Mesenchyme to epithelium transitions are crucial to embryonic development. The early mouse embryo offers an excellent model to study epithelium formation as during the first three days of development two epithelia are formed, the trophectoderm (TE) and the primitive endoderm (PrE). We have previously shown that PrE cells are determined within the blastocyst ICM long before epithelium formation. In this work, we isolated Lrp2 as a novel PrE precursor (pre-PrE) marker by using a microarray strategy that combines a transcriptome analysis of three stem cell lines and early embryos. A detailed expression analysis shows that Lrp2 expression is induced in late E3.5 embryos indicating that pre-PrE cells are progressively maturing prior to polarization into an epithelium. Furthermore, the subcellular location of Lrp2, Disabled-2 (Dab2) and Collagen-IV shows that the epithelial structure is acquired in individual cells through successive steps.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Gerbe F,Cox B,Rossant J,Chazaud Cdoi
10.1016/j.ydbio.2007.10.048subject
Has Abstractpub_date
2008-01-15 00:00:00pages
594-602issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(07)01493-5journal_volume
313pub_type
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pub_type： 杂志文章,评审
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