Quantitative analysis of cyclic AMP waves mediating aggregation in Dictyostelium discoideum.

abstract：:Ephrins and semaphorins regulate a wide variety of developmental processes, including axon guidance and cell migration. We have studied the roles of the ephrin EFN-4 and the semaphorin MAB-20 in patterning cell-cell contacts among the cells that give rise to the ray sensory organs of Caenorhabditis elegans. In wild-ty...

journal_title：Developmental biology

authors： Hahn AC,Emmons SW

更新日期：2003-04-15 00:00:00

abstract：:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...

journal_title：Developmental biology

authors： Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated ...

journal_title：Developmental biology

authors： Ohlsson R,Falck P,Hellström M,Lindahl P,Boström H,Franklin G,Ahrlund-Richter L,Pollard J,Soriano P,Betsholtz C

更新日期：1999-08-01 00:00:00

abstract：:Isotopes of a number of crustacean myofibrillar proteins have been identified with sodium dodecyl sulfate-polyacrylamide electrophoresis, and their distribution in muscles of the snapping shrimp has been examined. Fast-slow differences in distribution have been observed for myosin light chains and tropomyosin. In cont...

journal_title：Developmental biology

authors： Quigley MM,Mellon D Jr

更新日期：1984-11-01 00:00:00

abstract：:Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trime...

journal_title：Developmental biology

authors： Payne C,Braun RE

更新日期：2006-05-15 00:00:00

abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...

journal_title：Developmental biology

authors： Bonini NM,Leiserson WM,Benzer S

更新日期：1998-04-01 00:00:00

abstract：:In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...

journal_title：Developmental biology

authors： Ikegami R,Hunter P,Yager TD

更新日期：1999-05-15 00:00:00

abstract：:In this paper we present a structural and functional characterization of a new sea urchin embryo transcription factor, SpRunt-1. This factor was isolated by means of its specific interaction with a cis-regulatory target site of the CyIIIa gene. Here we show that this target site, the P7I site, is required for normal e...

journal_title：Developmental biology

authors： Coffman JA,Kirchhamer CV,Harrington MG,Davidson EH

更新日期：1996-02-25 00:00:00

abstract：:Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...

journal_title：Developmental biology

authors： Streit A

更新日期：2004-12-01 00:00:00

abstract：:Trypsin-like activity is secreted from eggs of many species at fertilization, and this activity is believed to be critical for the block to polyspermy. Here we show that a cortical granule serine protease of sea urchins is the major and perhaps only protease family member important for fertilization. Zymography assays...

journal_title：Developmental biology

authors： Haley SA,Wessel GM

更新日期：1999-07-01 00:00:00

abstract：:The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart ...

journal_title：Developmental biology

authors： Sugi Y,Markwald RR

更新日期：1996-04-10 00:00:00

abstract：:Understanding the biology of somatic stem cells in self renewing tissues represents an exciting field of study, especially given the potential to harness these cells for tissue regeneration and repair in treating injury and disease. The mammalian cornea contains a population of basal epithelial stem cells involved in ...

journal_title：Developmental biology

authors： Perry KJ,Thomas AG,Henry JJ

更新日期：2013-02-15 00:00:00

abstract：:We studied the pathway of 5S ribosomal RNA (rRNA) during oogenesis in Xenopus from its storage in the cytoplasm to incorporation into ribosomes in the nucleus. Ribonucleoprotein particle (RNP) assembly assays reveal striking differences in the behavior of oocyte-type and somatic-type 5S rRNA after microinjection into ...

journal_title：Developmental biology

authors： Allison LA,North MT,Neville LA

更新日期：1995-04-01 00:00:00

abstract：:Type II collagen is a major component of cartilage extracellular matrix. Differentiation of mesenchyme into cartilage involves the cessation of type I collagen synthesis and the onset of type II collagen synthesis. Solution hybridization of mRNA isolated from chick limb buds with a cDNA probe to type II collagen mRNA ...

journal_title：Developmental biology

authors： Swalla BJ,Upholt WB,Solursh M

更新日期：1988-01-01 00:00:00

abstract：:Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the branchial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive t...

journal_title：Developmental biology

authors： Smith CL

更新日期：1990-12-01 00:00:00

abstract：:During early vertebrate development, members of the transforming growth factor beta (TGFbeta) family play important roles in a variety of processes, including germ layer specification, patterning, cell differentiation, migration, and organogenesis. The activities of TGFbetas need to be tightly controlled to ensure the...

journal_title：Developmental biology

authors： Chang C,Eggen BJ,Weinstein DC,Brivanlou AH

更新日期：2003-03-01 00:00:00

abstract：:Early mammalian embryogenesis is controlled by mechanisms governing the balance between pluripotency and differentiation. The expression of early lineage-specific genes can vary significantly between species, with implications for developmental control and stem cell derivation. However, the mechanisms involved in patt...

journal_title：Developmental biology

authors： Niakan KK,Eggan K

更新日期：2013-03-01 00:00:00

abstract：:Fibroblast growth factor (FGF) signalling has been implicated in the generation of mesoderm and neural fates in chordate embryos including ascidians and vertebrates. In Ciona, FGF9/16/20 has been implicated in both of these processes. However, in FGF9/16/20 knockdown embryos, notochord fate recovers during later devel...

journal_title：Developmental biology

authors： Yasuo H,Hudson C

更新日期：2007-02-01 00:00:00

abstract：:Although communications between mammalian oocytes and their surrounding granulosa cells mediated by the Kit-Kit ligand (KL, or stem cell factor, SCF) system have been proven to be crucial for follicular development, Kit downstream signaling pathways in mammalian oocytes are largely unknown. In this study, by using ova...

journal_title：Developmental biology

authors： Reddy P,Shen L,Ren C,Boman K,Lundin E,Ottander U,Lindgren P,Liu YX,Sun QY,Liu K

更新日期：2005-05-15 00:00:00

abstract：:Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunor...

journal_title：Developmental biology

authors： Seth R,Shum L,Wu F,Wuenschell C,Hall FL,Slavkin HC,Warburton D

更新日期：1993-08-01 00:00:00

abstract：:Initiation of the development of the anterior-posterior axis in the mouse embryo has been thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetric migration. However, expression of Lefty1, a marker of the AVE, was recently found to initiate before embryo implantation. This...

journal_title：Developmental biology

authors： Torres-Padilla ME,Richardson L,Kolasinska P,Meilhac SM,Luetke-Eversloh MV,Zernicka-Goetz M

更新日期：2007-09-01 00:00:00

abstract：:The relationship among neuronal type, position, and time course of development of identified neurons was examined in the zebrafish (Brachydanio rerio). The cells studied, the reticulospinal neurons Mauthner, MiM1, and MiV1, are located within the same small region in the hindbrain, differ stereotypically in their posi...

journal_title：Developmental biology

authors： Mendelson B

更新日期：1985-12-01 00:00:00

abstract：:Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ER...

journal_title：Developmental biology

authors： Mulner-Lorillon O,Chassé H,Morales J,Bellé R,Cormier P

更新日期：2017-01-15 00:00:00

abstract：:Cells from newborn rat hindlimb show greatly enhanced myogenicity when grown on surfaces coated with poly-L-lysine followed by laminin (PLL/Lam) instead of the collagens routinely used. Coating with poly-L-lysine (PLL) alone or with PLL followed by collagen does not enhance myogenicity. Both myogenic and nonmyogenic c...

journal_title：Developmental biology

authors： Foster RF,Thompson JM,Kaufman SJ

更新日期：1987-07-01 00:00:00

abstract：:The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...

journal_title：Developmental biology

authors： Zoran MJ,Funte LR,Kater SB,Haydon PG

更新日期：1993-07-01 00:00:00

abstract：:Vimentin expression in the lens is striking due to the reported mesenchymal preference of vimentin and the epithelial origin of the lens. The amount of chicken vimentin mRNA levels determined by Northern blot analysis increased 3-fold from 7 to 14 days of embryonic lens development and then decreased 10-fold at 16 day...

journal_title：Developmental biology

authors： Sax CM,Farrell FX,Zehner ZE,Piatigorsky J

更新日期：1990-05-01 00:00:00

abstract：:At gastrulation in the sea urchin embryo dramatic cell adhesion changes contribute to primary mesenchyme cell ingression movements and to cell rearrangements during archenteron invagination. At ingression, quantitative adhesion assays demonstrated previously that primary mesenchyme cells (PMCs) change their affinity f...

journal_title：Developmental biology

authors： Hertzler PL,McClay DR

更新日期：1999-03-01 00:00:00

abstract：:Hox genes are crucial players in the generation and pattering of the vertebrate trunk and posterior body during embryogenesis. Their initial expression takes place shortly after the establishment of the primitive streak, in the posterior-most part of the mouse embryo and is a determinant step for setting up the defini...

journal_title：Developmental biology

authors： Neijts R,Deschamps J

更新日期：2017-08-15 00:00:00

abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

journal_title：Developmental biology

authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

更新日期：2008-02-15 00:00:00

abstract：:The murine homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during mouse embryogenesis. We now report the developmentally regulated expression of Msx-1 and Msx-2 in the mouse mammary gland and show that their expression patterns point toward significant fu...

journal_title：Developmental biology

authors： Friedmann Y,Daniel CW

更新日期：1996-07-10 00:00:00