Abstract：
:The murine homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during mouse embryogenesis. We now report the developmentally regulated expression of Msx-1 and Msx-2 in the mouse mammary gland and show that their expression patterns point toward significant functional roles. Msx-1 and Msx-2 transcripts were present in glands of virgin mice and in glands of mice in early pregnancy, but transcripts decreased dramatically during late pregnancy. Low levels of Msx-1 transcripts were detected in glands from lactating animals and during the first days of involution, whereas Msx-2 expression was not detected during lactation or early involution. Expression of both genes increased gradually as involution progressed. Msx-2 but not Msx-1 expression was decreased following ovariectomy or following exposure to anti-estrogen implanted directly into the gland. Hormonal regulation of Msx-2 expression was confirmed when transcripts returned to normal levels after estrogen was administered to ovariectomized animals. In situ molecular hybridization for Msx-1 showed transcripts localized to the mammary epithelium, whereas Msx-2 expression was confined to the periductal stroma. Mammary stroma from which mammary epithelium had been removed did not transcribe detectable amounts of Msx-2, showing that expression is regulated by contiguous mammary epithelium, and indicating a role for these homeobox genes in mesenchymal-epithelial interactions during mammary development.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Friedmann Y,Daniel CWdoi
10.1006/dbio.1996.0168subject
Has Abstractpub_date
1996-07-10 00:00:00pages
347-55issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(96)90168-2journal_volume
177pub_type
杂志文章abstract：:We describe mesendoderm morphogenesis during gastrulation in the frog Xenopus laevis and investigate the mechanics of these movements with tissue explants. When a dorsal marginal zone explant is plated onto fibronectin, the mesendoderm moves away from the dorsal axial tissues as an intact sheet. Mesendodermal cells wi...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2002.0537
更新日期：2002-02-15 00:00:00
abstract：:Artificial extracellular matrices composed of collagen, glycosaminoglycans (GAG), proteoglycans (PG), plasma fibronectin (FN), and a hyaluronate-binding protein (HABP) have been prepared that morphologically resemble embryonic extracellular matrices in vivo at the light and electron microscope level. The effect of eac...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/0012-1606(85)90461-0
更新日期：1985-06-01 00:00:00
abstract：:Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2003.06.003
更新日期：2004-01-01 00:00:00
abstract：:Full-grown Xenopus oocytes, Stage VI (1200-1300 microns), undergo meiotic maturation when exposed to progesterone. Smaller stage IV (800 microns) and stage V (1000 microns) oocytes remain in prophase arrest when exposed to this steroid. The larger stage VI oocytes undergo an intracellular alkalization from 7.2 to 7.6,...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90288-4
更新日期：1984-10-01 00:00:00
abstract：:Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of w...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/s0012-1606(02)00046-5
更新日期：2003-03-01 00:00:00
abstract：:The ectodomain of LIN-12/Notch proteins is cleaved and shed upon ligand binding. In Caenorhabditis elegans, genetic evidence has implicated SUP-17, the ortholog of Drosophila Kuzbanian and mammalian ADAM10, as the protease that mediates this event. In mammals, however, biochemical evidence has implicated TACE, a diffe...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.08.014
更新日期：2005-11-01 00:00:00
abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(92)90014-8
更新日期：1992-03-01 00:00:00
abstract：:We have performed a detailed analysis of the expression pattern of the three gnathostome Otx classes in order to gain new insights into their functional evolution. Expression patterns were examined in the developing eye of a chondrichthyan, the dogfish, and an amniote, the chick, and compared with the capacity of para...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.11.019
更新日期：2005-02-15 00:00:00
abstract：:Regulation of gene expression during early embryonic development in the rabbit was investigated by quantitative assay of firefly luciferase activity obtained by microinjection of three plasmid constructs using the regulatory region of polyomavirus promoter (PrPyV) with two different enhancer sequences (wild type or mu...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1188
更新日期：1994-07-01 00:00:00
abstract：:Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in vertebrates. It is also an important immune defense, quickly forming a secondary barrier to infection, immobilizing bacteria and thereby promoting their killing. However, hemolymph clotting is one of the least understood immu...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.03.019
更新日期：2006-07-01 00:00:00
abstract：:We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9246
更新日期：1999-05-01 00:00:00
abstract：:We have isolated Xbr-1, a novel Xenopus homeobox gene that defines a new class of homeobox genes, distantly related to the Drosophila BarH1 and BarH2 genes. Xbr-1 is predominantly expressed in the developing Xenopus eye, starting as early as the neural plate stage. At early stages of eye development XBR-1 is expressed...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.0055
更新日期：1996-02-25 00:00:00
abstract：:Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2004.08.037
更新日期：2004-12-01 00:00:00
abstract：:Stromal fibroblasts from the adult rabbit cornea were propagated in vitro, then injected into the vitreous compartment of normal rabbit eyes. In this environment the stromal cells deposited a matrix of imperfect orthogonal collagenous lamellae resembling normal corneal stroma. Extracellular matrices were also secreted...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(85)90028-4
更新日期：1985-03-01 00:00:00
abstract：:To examine the possible role of homeo box genes in murine development we have studied the structure and expression pattern of Hox-2.5, a newly isolated homeo box gene that maps to the left end of the mouse Hox-2 locus on chromosome 11. The sequence of the Hox-2.5 homeo box has been determined. It is highly homologous ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(89)90056-0
更新日期：1989-06-01 00:00:00
abstract：:Mammalian oocytes are arrested in meiotic prophase from around the time of birth until just before ovulation. Following an extended period of growth, they are stimulated to mature to the metaphase II stage by a preovulatory luteinizing hormone (LH) surge that occurs with each reproductive cycle. Small, growing oocytes...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2017.12.014
更新日期：2018-02-01 00:00:00
abstract：:Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1312
更新日期：1994-11-01 00:00:00
abstract：:We recently discovered that in rat spermatids, kinesin light chain KLC3 can associate with outer dense fibers, major sperm tail components, and accumulates in the sperm midpiece. Here, we show that mitochondria isolated from rat-elongating spermatids have bound KLC3. Immunoelectron microscopy indicates that the associ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.07.014
更新日期：2004-11-01 00:00:00
abstract：:The relative sizes of the various structures in Hydra attenuata were compared over a broad range of animal sizes to determine in detail the ability to regulate proportions during regeneration. The three components of the head, namely hypostome, tentacles, and tentacle zone from which the tentacles emerge, the body col...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90318-x
更新日期：1984-06-01 00:00:00
abstract：:Concentration of mast-cell precursors in hematopoietic tissues of mouse embryos was evaluated by a limiting dilution method. Cells from yolk sacs, livers, and bodies of (WB x C57BL/6)F1 (hereafter called WBB6F1)- +/+ embryos were injected directly into the skin of adult WBB6F1-W/Wv mice which were genetically depleted...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90066-0
更新日期：1983-05-01 00:00:00
abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.9847
更新日期：2000-10-01 00:00:00
abstract：:One function of the Wingless signaling pathway is to determine the naked, cuticle cell fate choice in the trunk epidermis of Drosophila larvae. The zinc finger protein Teashirt binds to the transactivator domain of Armadillo to modulate Wingless signaling output in the embryonic trunk and contributes to the naked cell...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2001.0498
更新日期：2002-01-01 00:00:00
abstract：:Lipids are essential for cellular function as sources of fuel, critical signaling molecules and membrane components. Deficiencies in lipid processing and transport underlie many metabolic diseases. To better understand metabolic function as it relates to disease etiology, a whole animal approach is advantageous, one i...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2011.09.010
更新日期：2011-12-15 00:00:00
abstract：:Nematodes provide a useful experimental system with which to investigate the evolution of development at the cellular, genetic, and molecular levels. Building on an understanding of vulval development in Caenorhabditis elegans, analysis of vulval development has been extended to a number of other species in three fami...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1006/dbio.1996.0035
更新日期：1996-02-01 00:00:00
abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.9811
更新日期：2000-10-01 00:00:00
abstract：:Sex in the nematode Caenorhabditis elegans is normally determined by the X chromosome to autosome (X:A) ratio, with XX hermaphrodites and XO males. Previous work has shown that a set of at least four autosomal genes (her-1, tra-2, tra-3, and tra-1) is signaled by the X:A ratio and appears to act in a regulatory pathwa...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90077-0
更新日期：1984-11-01 00:00:00
abstract：:Epithelial-mesenchymal interactions are of major importance during development to direct correct differentiation and morphogenesis of embryonic tissues. One subset of lateral mesoderm-derived mesenchymal cells will form the smooth muscle (SM) layer of the primary epithelial lining of hollow internal organs. It has bee...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1207
更新日期：1994-08-01 00:00:00
abstract：:Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90275-0
更新日期：1983-09-01 00:00:00
abstract：:CREB-2 (also called ATF4, TAXREB67, or C/ATF) is an evolutionarily conserved member of the CREB/ATF family of basic-leucine zipper transcription factors. CREB-2 is expressed ubiquitously in the adult mouse and can function as both a transcriptional activator and a repressor. However, little was understood about the no...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.9699
更新日期：2000-06-01 00:00:00
abstract：:Previous studies have established that embryonal carcinoma (EC) cells produce several different growth factors, but express few, if any, receptors for epidermal growth factor, platelet-derived growth factor, or transforming growth factor type-beta. In this study, the production and utilization of fibroblast growth fac...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(88)90161-3
更新日期：1988-09-01 00:00:00
