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Pax6 regulates regional development and neuronal migration in the cerebral cortex.

Abstract：

:Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of wild-type and Pax6-deficient cells. The chimeric analysis shows that Pax6 influences cellular activity throughout corticogenesis. At early stages, Pax6-deficient and wildtype cells segregate into exclusive patches, indicating an inability of different cell genotypes to interact. At later stages, cells are sorted further based on telencephalic domains. Pax6-deficient cells are specifically reduced in the mediocaudal domain of the dorsal telencephalon, indicating a role in regionalization. In addition, Pax6 regulates the process of radial migration of neuronal precursors. Loss of Pax6 particularly affects movement of neuronal precursors at the subventricular zone/intermediate zone boundary at a transitional migratory phase essential for entry into the intermediate zone. We suggest that the primary role of Pax6 is the continual regulation of cell surface properties responsible for both cellular identity and radial migration, defects of which cause regional cell sorting and abnormalities of migration in chimeras.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Talamillo A,Quinn JC,Collinson JM,Caric D,Price DJ,West JD,Hill RE

doi

10.1016/s0012-1606(02)00046-5

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

151-63

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012160602000465

journal_volume

255

pub_type

杂志文章

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