Effect of an inhibitory mutant of the FGF receptor on mesoderm-derived alpha-smooth muscle actin-expressing cells in Xenopus embryo.

Abstract:

:Epithelial-mesenchymal interactions are of major importance during development to direct correct differentiation and morphogenesis of embryonic tissues. One subset of lateral mesoderm-derived mesenchymal cells will form the smooth muscle (SM) layer of the primary epithelial lining of hollow internal organs. It has been previously reported that the differentiation of SM cells in Xenopus laevis can be followed by the expression of alpha-SM actin. It was also shown that basic fibroblast growth factor (bFGF) had the ability to induce this actin isoform in isolated blastula animal caps. In this paper, by injection at the two-cell stage of mRNA encoding a truncated form of the FGF receptor which can act as a dominant negative inhibitor, we have analyzed the role of the FGF signaling pathway in the formation of the SM lineage. We have observed that mutated embryos presented significant delay in the differentiation of the SM cells compared to control embryos, demonstrating the importance of this signaling pathway for the formation of the lateral mesoderm-derived SM cells. Moreover, a correlation could be established between this delay and the dramatic defects observed in the morphogenesis of the intestine with which mesenchyme-derived SM cells are normally associated. This phenotype was efficiently rescued by coinjection of the wild-type FGF receptor. Our data suggest that the differentiation of SM cells at the correct time could be an essential event for the proper morphogenesis of the endoderm-derived digestive tract.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Saint-Jeannet JP,Thiery JP,Koteliansky VE

doi

10.1006/dbio.1994.1207

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

374-82

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(84)71207-3

journal_volume

164

pub_type

杂志文章
  • Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.

    abstract::The primary lung bud originates from the foregut and develops into the bronchial tree by repetitive branching and outgrowing of the airway. The Sry related HMG box protein Sox2 is expressed in a cyclic manner during initiation and branching morphogenesis of the lung. It is highly expressed in non-branching regions and...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.02.035

    authors: Gontan C,de Munck A,Vermeij M,Grosveld F,Tibboel D,Rottier R

    更新日期:2008-05-01 00:00:00

  • In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development.

    abstract::Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.10.014

    authors: Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

    更新日期:2009-01-01 00:00:00

  • Patchy interspecific sequence similarities efficiently identify positive cis-regulatory elements in the sea urchin.

    abstract::We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory networ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2002.0618

    authors: Yuh CH,Brown CT,Livi CB,Rowen L,Clarke PJ,Davidson EH

    更新日期:2002-06-01 00:00:00

  • Modulation of the Ras/MAPK signalling pathway by the redox function of selenoproteins in Drosophila melanogaster.

    abstract::Modulation of reactive oxygen species (ROS) plays a key role in signal transduction pathways. Selenoproteins act controlling the redox balance of the cell. We have studied how the alteration of the redox balance caused by patufet (selD(ptuf)), a null mutation in the Drosophila melanogaster selenophosphate synthetase 1...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0389

    authors: Morey M,Serras F,Baguñà J,Hafen E,Corominas M

    更新日期:2001-10-01 00:00:00

  • Abnormal keratinization in the pupoid fetus (pf/pf) mutant mouse epidermis.

    abstract::During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90194-5

    authors: Fisher C,Dale BA,Kollar EJ

    更新日期:1984-04-01 00:00:00

  • Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS.

    abstract::The subventricular zone (SVZ) of the developing mammalian forebrain gives rise to astrocytes and oligodendrocytes in the neocortex and white matter, and neurons in the olfactory bulb in perinatal life. We have examined the developmental fates and spatial distributions of the descendants of single SVZ cells by infectin...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.02.024

    authors: Zerlin M,Milosevic A,Goldman JE

    更新日期:2004-06-01 00:00:00

  • Expression of pluripotency factors in larval epithelia of the frog Xenopus: evidence for the presence of cornea epithelial stem cells.

    abstract::Understanding the biology of somatic stem cells in self renewing tissues represents an exciting field of study, especially given the potential to harness these cells for tissue regeneration and repair in treating injury and disease. The mammalian cornea contains a population of basal epithelial stem cells involved in ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2012.12.005

    authors: Perry KJ,Thomas AG,Henry JJ

    更新日期:2013-02-15 00:00:00

  • Laser ablation of the sonic hedgehog-a-expressing cells during fin regeneration affects ray branching morphogenesis.

    abstract::The zebrafish fin is an excellent system to study the mechanisms of dermal bone patterning. Fin rays are segmented structures that form successive bifurcations both during ontogenesis and regeneration. Previous studies showed that sonic hedgehog (shha) may regulate regenerative bone patterning based on its expression ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2012.03.008

    authors: Zhang J,Jeradi S,Strähle U,Akimenko MA

    更新日期:2012-05-15 00:00:00

  • Strains matter: Success of murine in vitro spermatogenesis is dependent on genetic background.

    abstract::The current strategy to preserve fertility of male prepubertal cancer patients consists of cryopreservation of a testicular tissue biopsy containing spermatogonial stem cells (SSCs). While in humans, fertility restoration strategies from prepubertal testicular tissues are still under investigation and have not yet res...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2019.08.007

    authors: Portela JMD,Mulder CL,van Daalen SKM,de Winter-Korver CM,Stukenborg JB,Repping S,van Pelt AMM

    更新日期:2019-12-01 00:00:00

  • Ontogeny of the mouse vocal fold epithelium.

    abstract::This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.12.037

    authors: Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

    更新日期:2015-03-15 00:00:00

  • Direct flight muscles in Drosophila develop from cells with characteristics of founders and depend on DWnt-2 for their correct patterning.

    abstract::The direct flight muscles (DFMs) of Drosophila allow for the fine control of wing position necessary for flight. In DWnt-2 mutant flies, certain DFMs are either missing or fail to attach to the correct epithelial sites. Using a temperature-sensitive allele, we show that DWnt-2 activity is required only during pupation...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2002.0572

    authors: Kozopas KM,Nusse R

    更新日期:2002-03-15 00:00:00

  • Alignment of centrosomal and growth axes is a late event during polarization of Pelvetia compressa zygotes.

    abstract::Zygotes and embryos of the fucoid brown alga Pelvetia compressa undergo a series of asymmetric cleavages. We are interested in the developmental role of these cleavages and the mechanism controlling their alignment. To assess the importance of division plane alignment, the orientation of the first asymmetric division ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8832

    authors: Bisgrove SR,Kropf DL

    更新日期:1998-02-15 00:00:00

  • DNA sequences mediating the transcriptional response of the Mix.2 homeobox gene to mesoderm induction.

    abstract::Peptide growth factors can initiate changes in cell fate in Xenopus ectodermal explants and induce the formation of mesoderm. Marker genes expressed in mesoderm allow the analysis of whether, or how much, induction has occurred, but do not tell us what molecules are involved in carrying out the response. In this repor...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0158

    authors: Vize PD

    更新日期:1996-07-10 00:00:00

  • CK2α regulates the transcription of BRP in Drosophila.

    abstract::Development and plasticity of synapses are brought about by a complex interplay between various signaling pathways. Typically, either changing the number of synapses or strengthening an existing synapse can lead to changes during synaptic plasticity. Altering the machinery that governs the exocytosis of synaptic vesic...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.09.025

    authors: Wairkar YP,Trivedi D,Natarajan R,Barnes K,Dolores L,Cho P

    更新日期:2013-12-01 00:00:00

  • Temporal expression of regulatory and structural muscle proteins during myogenesis of satellite cells on isolated adult rat fibers.

    abstract::Myogenic precursors in adult skeletal muscle (satellite cells) are mitotically quiescent but can proliferate in response to a variety of stresses including muscle injury. To gain further understanding of adult myoblasts, we analyzed myogenesis of satellite cells on intact fibers isolated from adult rat muscle. In this...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1994.1226

    authors: Yablonka-Reuveni Z,Rivera AJ

    更新日期:1994-08-01 00:00:00

  • A divergent Tbx6-related gene and Tbx6 are both required for neural crest and intermediate mesoderm development in Xenopus.

    abstract::T-box family transcription factors play many roles in Metazoan development. Here we characterise Tbx6r, a unique Tbx6 paralogue isolated from the amphibian Xenopus. The evolution and developmental integration of this divergent T-box gene within the vertebrates reveals an unexpected level of plasticity within this cons...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.01.013

    authors: Callery EM,Thomsen GH,Smith JC

    更新日期:2010-04-01 00:00:00

  • CLIP-50 immunolocalization during mouse spermiogenesis suggests a role in shaping the sperm nucleus.

    abstract::The spermatid nucleus and cytoplasm undergo dramatic morphological modifications during spermatid differentiation into mature sperm. Some of the external force causing this nuclear shaping is generated by a microtubular structure termed the manchette, which attaches to the perinuclear ring of the spermatid. Here, we r...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0286

    authors: Tarsounas M,Pearlman RE,Moens PB

    更新日期:2001-08-15 00:00:00

  • Ontogenesis of chick iris intrinsic muscles: evidence for a smooth-to-striated muscle transition.

    abstract::The iris sphincter muscle consists of striated muscle fibers in the adult chicken. The ontogenetic development of this muscle has been studied by immunocytochemistry, from Embryonic Day 7 to the time of hatching. The time course of expression of specific markers of either smooth or striated muscle, i.e., smooth and sk...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1993.1254

    authors: Volpe P,Biral D,Pizzo P,Salviati G,Margreth A

    更新日期:1993-10-01 00:00:00

  • Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.

    abstract::Aurora-C was first identified during screening for kinases expressed in mouse sperm and eggs. Herein, we report for the first time the precise subcellular localization of endogenous Aurora-C during male meiotic division. The localization of Aurora-C was analyzed by immunofluorescence staining on chromosome spreads of ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.11.036

    authors: Tang CJ,Lin CY,Tang TK

    更新日期:2006-02-15 00:00:00

  • The Toll immune-regulated Drosophila protein Fondue is involved in hemolymph clotting and puparium formation.

    abstract::Clotting is critical in limiting hemolymph loss and initiating wound healing in insects as in vertebrates. It is also an important immune defense, quickly forming a secondary barrier to infection, immobilizing bacteria and thereby promoting their killing. However, hemolymph clotting is one of the least understood immu...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.03.019

    authors: Scherfer C,Qazi MR,Takahashi K,Ueda R,Dushay MS,Theopold U,Lemaitre B

    更新日期:2006-07-01 00:00:00

  • In vivo regulation of cytostatic activity in Xenopus metaphase II-arrested oocytes.

    abstract::Metaphase II arrest of Xenopus oocyte is characterized by the presence of M-phase-promoting factor (MPF) and of a microtubular spindle, both of which are stable in the presence of protein synthesis inhibitors. We studied in vivo this equilibrium state that is settled during meiotic maturation. At time of germinal vesi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8543

    authors: Thibier C,De Smedt V,Poulhe R,Huchon D,Jessus C,Ozon R

    更新日期:1997-05-01 00:00:00

  • The effect of agrin and laminin on acetylcholine receptor dynamics in vitro.

    abstract::Using optical imaging assays, we investigated the dynamics of acetylcholine receptors (AChRs) at laminin-associated clusters on cultured myotubes in the absence or presence of the nerve-derived clustering factor, agrin. Using fluorescence recovery after photobleaching (FRAP) on fluorescent bungarotoxin-labeled recepto...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.09.041

    authors: Bruneau EG,Macpherson PC,Goldman D,Hume RI,Akaaboune M

    更新日期:2005-12-01 00:00:00

  • Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.

    abstract::CREB-2 (also called ATF4, TAXREB67, or C/ATF) is an evolutionarily conserved member of the CREB/ATF family of basic-leucine zipper transcription factors. CREB-2 is expressed ubiquitously in the adult mouse and can function as both a transcriptional activator and a repressor. However, little was understood about the no...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2000.9699

    authors: Hettmann T,Barton K,Leiden JM

    更新日期:2000-06-01 00:00:00

  • Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest.

    abstract::We have isolated two related Xenopus homologues of the homeotic zinc finger protein Teashirt1 (Tsh1), XTsh1a and XTsh1b. While Drosophila teashirt specifies trunk identity in the fly, the developmental relevance of vertebrate Tsh homologues is unknown. XTsh1a/b are expressed in prospective trunk CNS throughout early n...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.06.041

    authors: Koebernick K,Kashef J,Pieler T,Wedlich D

    更新日期:2006-10-01 00:00:00

  • Structural analysis of three subunits of laminin from teratocarcinoma-derived parietal endoderm cells.

    abstract::The structure of the three polypeptide chains of the laminin subunits and the number of glycosylation sites in each polypeptide chain were determined using peptide mapping by high-performance liquid chromatography. Analysis of the [35S]methionine-labeled underglycosylated laminin isolated from tunicamycin (TM)-treated...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(83)90367-6

    authors: Howe CC,Dietzschold B

    更新日期:1983-08-01 00:00:00

  • Temporal separation of the migration of distinct myogenic precursor populations into the developing chick wing bud.

    abstract::The developing chick limb bud contains several stage-specific populations of muscle colony-forming (MCF) cells. The cell lineage relationships of these populations are not completely understood, but previous studies have suggested that there may be at least two myogenic precursor populations present in the limb bud. T...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90237-9

    authors: Seed J,Hauschka SD

    更新日期:1984-12-01 00:00:00

  • AMPK regulation of mouse oocyte meiotic resumption in vitro.

    abstract::We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential rol...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.11.039

    authors: Chen J,Hudson E,Chi MM,Chang AS,Moley KH,Hardie DG,Downs SM

    更新日期:2006-03-15 00:00:00

  • In vitro penetration of hamster oocyte-cumulus complexes using physiological numbers of sperm.

    abstract::We have compared the ability of uncapacitated, capacitated acrosome intact, and acrosome-reacted hamster sperm to penetrate the cumulus and corona radiata of fresh hamster oocyte-cumulus complexes (OCC) in vitro. This was done using physiological numbers (1-20) of sperm so that cumulus and corona radiata cells did not...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90348-4

    authors: Corselli J,Talbot P

    更新日期:1987-07-01 00:00:00

  • Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.

    abstract::The mammalian kidney collecting ducts are critical for water, electrolyte and acid-base homeostasis and develop as a branched network of tubular structures composed of principal cells intermingled with intercalated cells. The intermingled nature of the different collecting duct cell types has made it challenging to id...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2017.02.007

    authors: Grassmeyer J,Mukherjee M,deRiso J,Hettinger C,Bailey M,Sinha S,Visvader JE,Zhao H,Fogarty E,Surendran K

    更新日期:2017-04-01 00:00:00

  • Extracellular ubiquitin system implicated in fertilization of the ascidian, Halocynthia roretzi: isolation and characterization.

    abstract::The ubiquitin-proteasome system is essential for intracellular protein degradation, but there are few studies of this system in the extracellular milieu. Recently, we reported that a 70-kDa sperm receptor, HrVC70, on the vitelline coat is ubiquitinated and then degraded by the sperm proteasome during fertilization of ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2003.07.016

    authors: Sakai N,Sawada H,Yokosawa H

    更新日期:2003-12-01 00:00:00