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MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos.

Abstract：

:Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ERK fraction. Nonetheless, the chromatin and spindle organisations are profoundly altered. Early morphological disorders induced by the absence of MAPK/ERK activation are correlated with an important inhibition of global protein synthesis and modification in the cyclin B accumulation profile. After appearance of morphological disorders, there is an increase in the level of the inhibitor of protein synthesis, 4E-BP, and, ultimately, an activation of the spindle checkpoint. Altogether, our results suggest that MAPK/ERK activity is required for the synthesis of (a) protein(s) implicated in an early step of chromatin /microtubule attachment. If this MAPK/ERK-dependent step is not achieved, the cell activates a new checkpoint mechanism, involving the reappearance of 4E-BP that maintains a low level of protein translation, thus saving cellular energy.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Mulner-Lorillon O,Chassé H,Morales J,Bellé R,Cormier P

doi

10.1016/j.ydbio.2016.11.018

subject

Has Abstract

pub_date

2017-01-15 00:00:00

pages

194-203

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(16)30383-9

journal_volume

421

pub_type

杂志文章

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