Abstract：
:The contractile proteins of skeletal muscle are often represented by families of very similar isoforms. Protein isoforms can result from the differential expression of multigene families or from multiple transcripts from a single gene via alternative splicing. In many cases the regulatory mechanisms that determine the accumulation of specific isoforms via alternative splicing or differential gene expression are being unraveled. However, the functional significance of expressing different proteins during muscle development remains a key issue that has not been resolved. It is widely believed that distinct isoforms within a family are uniquely adapted to muscles with different physiological properties, since separate isoform families are often coordinately regulated within functionally distinct muscle fiber types. It is also possible that different isoforms are functionally indistinguishable and represent an inherent genetic redundancy among critically important muscle proteins. The goal of this review is to assess the evidence that muscle proteins which exist as different isoforms in developing and mature skeletal and cardiac muscles are functionally unique. Since regulation of both transcription and alternative splicing within multigene families may also be an important factor determining the accumulation of specific protein isoforms, evidence that genetic regulation rather than protein coding information provides the functional basis of isoform diversity is also examined.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Bandman Edoi
10.1016/0012-1606(92)90067-qsubject
Has Abstractpub_date
1992-12-01 00:00:00pages
273-83issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(92)90067-Qjournal_volume
154pub_type
杂志文章,评审abstract：:The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...
journal_title：Developmental biology
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journal_title：Developmental biology
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更新日期：1993-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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