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Developmental clustering of ion channels at and near the node of Ranvier.

Abstract：

:Voltage-gated Na(+) and K(+) channels are localized to distinct subcellular domains in mammalian myelinated nerve fibers. Specifically, Na(+) channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal zones just beyond regions of axoglial contact where sequential layers of the myelin sheath terminate. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation. The cellular, molecular, and developmental mechanisms that exist to achieve this neuronal specialization are discussed and reviewed. Current evidence points to a prominent role in channel clustering played by myelinating glial cells, and sites of axoglial contact in particular.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Rasband MN,Trimmer JS

doi

10.1006/dbio.2001.0326

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

5-16

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(01)90326-4

journal_volume

236

pub_type

杂志文章,评审

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