Functional domains and temperature-sensitive mutations in SPE-9, an EGF repeat-containing protein required for fertility in Caenorhabditis elegans.

abstract：:Oocyte maturation in mouse is associated with a dramatic reorganisation of the endoplasmic reticulum (ER) from a network of cytoplasmic accumulations in the germinal vesicle-stage oocyte (GV) to a network of distinctive cortical clusters in the metaphase II egg (MII). Multiple lines of evidence suggest that this redis...

journal_title：Developmental biology

authors： FitzHarris G,Marangos P,Carroll J

更新日期：2007-05-01 00:00:00

abstract：:Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...

journal_title：Developmental biology

authors： Mitchison TJ,Sedat J

更新日期：1983-09-01 00:00:00

abstract：:The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

journal_title：Developmental biology

authors： Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

更新日期：2019-12-01 00:00:00

abstract：:The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...

journal_title：Developmental biology

authors： Merz DC,Alves G,Kawano T,Zheng H,Culotti JG

更新日期：2003-04-01 00:00:00

abstract：:Unlike adult mammals, adult frogs regrow their optic nerve following a crush injury, making Xenopus laevis a compelling model for studying the molecular mechanisms that underlie neuronal regeneration. Using Translational Ribosome Affinity Purification (TRAP), a method to isolate ribosome-associated mRNAs from a target...

journal_title：Developmental biology

authors： Whitworth GB,Misaghi BC,Rosenthal DM,Mills EA,Heinen DJ,Watson AH,Ives CW,Ali SH,Bezold K,Marsh-Armstrong N,Watson FL

更新日期：2017-06-15 00:00:00

abstract：:Much progress has been made in elucidating the molecular networks required for specifying retinal cells, including photoreceptors, but the downstream mechanisms that maintain identity and regulate differentiation remain poorly understood. Here, we report that the transcription factor Glass has a dual role in establish...

journal_title：Developmental biology

authors： Liang X,Mahato S,Hemmerich C,Zelhof AC

更新日期：2016-06-01 00:00:00

abstract：:Using an in vitro model of rat epiphyseal chondrocyte differentiation in which cells are maintained in a three-dimensional cell pellet, we show that exogenous TGF-beta 1 reversibly prevents terminal differentiation of epiphyseal chondrocytes into hypertrophic cells. Through maintenance of gene expression for the carti...

journal_title：Developmental biology

authors： Ballock RT,Heydemann A,Wakefield LM,Flanders KC,Roberts AB,Sporn MB

更新日期：1993-08-01 00:00:00

abstract：:Previous studies have established that embryonal carcinoma (EC) cells produce several different growth factors, but express few, if any, receptors for epidermal growth factor, platelet-derived growth factor, or transforming growth factor type-beta. In this study, the production and utilization of fibroblast growth fac...

journal_title：Developmental biology

authors： Rizzino A,Kuszynski C,Ruff E,Tiesman J

更新日期：1988-09-01 00:00:00

abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

journal_title：Developmental biology

authors： Jones KT,Nixon VL

更新日期：2000-09-01 00:00:00

abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

journal_title：Developmental biology

authors： Carlson JR,Hogness DS

更新日期：1985-04-01 00:00:00

abstract：:In mouse chimeras with parthenogenetic cell contribution, the skeletal musculature appears to be largely devoid of parthenogenetically derived cells. To analyze the appearance and early distribution of myotomal cells in parthenotes, we determined the expression of the muscle-specific transcription factors myogenin, MY...

journal_title：Developmental biology

authors： Fundele R,Bober E,Arnold HH,Grim M,Bender R,Wilting J,Christ B

更新日期：1994-01-01 00:00:00

abstract：:Drosophila nemo (nmo) and other Nemo-like kinase family members (Nlks) are well-established key regulators of numerous conserved signaling pathways, such as Wg and BMP. nmo mutants display pleiotropic defects at different developmental stages, including the embryo. In this study we describe a detailed characterization...

journal_title：Developmental biology

authors： Braid LR,Lee W,Uetrecht AC,Swarup S,Papaianni G,Heiler A,Verheyen EM

更新日期：2010-07-01 00:00:00

abstract：:In ascidian embryos, the earliest transcription from the zygotic genome begins between the 8-cell and 16-cell stages. Gata.a, a maternally expressed Gata transcription factor, activates target genes specifically in the animal hemisphere, whereas the complex of β-catenin and Tcf7 antagonizes the activity of Gata.a and ...

journal_title：Developmental biology

authors： Imai KS,Kobayashi K,Kari W,Rothbächer U,Ookubo N,Oda-Ishii I,Satou Y

更新日期：2020-02-15 00:00:00

abstract：:To determine whether spontaneous release of transmitter from the growth cones of neurons exhibits properties similar to the spontaneous release which occurs from the neurons at the neuromuscular junction, release of transmitter from the growth cones of Xenopus neurons in culture was monitored in salines containing var...

journal_title：Developmental biology

authors： Young SH

更新日期：1986-02-01 00:00:00

abstract：:A modification of the scrape-loading/dye transfer technique was used to study gap junctional communication along the anterior-posterior (A-P) axis of embryonic chick wing buds at an early stage of development (stage 20/21) when positional values along the A-P axis are being specified. Extensive intercellular transfer ...

journal_title：Developmental biology

authors： Coelho CN,Kosher RA

更新日期：1991-12-01 00:00:00

abstract：:In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...

journal_title：Developmental biology

authors： Li M,Babenko NA,Sakaguchi DS

更新日期：2004-02-01 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...

journal_title：Developmental biology

authors： Bruder SP,Caplan AI

更新日期：1990-10-01 00:00:00

abstract：:Plakoglobin and beta-catenin are cytoplasmic proteins associated with the intracellular plaques of cell adhesive junctions. While plakoglobin is present in both adherens junctions and desmosomes, beta-catenin is associated with the cadherins that accumulate only in adherens junctions. Both beta-catenin and plakoglobin...

journal_title：Developmental biology

authors： DeMarais AA,Moon RT

更新日期：1992-10-01 00:00:00

abstract：:In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...

journal_title：Developmental biology

authors： Savage RM,Danilchik MV

更新日期：1993-06-01 00:00:00

abstract：:The cardiac neural crest contains ectomesenchymal and neural anlagen that are necessary for normal heart development. It is not known whether other regions of the neural crest are capable of supporting normal heart development. In the experiments reported herein, quail donor embryos provided cardiac, trunk, or mesence...

journal_title：Developmental biology

authors： Kirby ML

更新日期：1989-08-01 00:00:00

abstract：:The four members of the albumin gene family encode the serum transport proteins albumin, alpha-fetoprotein, alpha-albumin, and vitamin D-binding protein. These genes are transcribed primarily in the liver with each having a different pattern of developmental expression. The tight linkage of these genes, particularly t...

journal_title：Developmental biology

authors： Jin L,Long L,Green MA,Spear BT

更新日期：2009-12-15 00:00:00

abstract：:We have studied the effect of saline and acid extracts of chick brain on the total number of acetylcholine (ACh) receptors and the number of receptor clusters in cultured chick muscle cells. Myotubes in 7-day cultures responded more rapidly to brain extract than did myotubes in 4-day cultures, so the older cells were ...

journal_title：Developmental biology

authors： Buc-Caron MH,Nystrom P,Fischbach GD

更新日期：1983-02-01 00:00:00

abstract：:The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors. The carboxy-terminal region of SMRT contains CoRNR box motifs that mediate these interactions. We have shown, in Xenopus, that SMRT can exist as isoforms containing either two or three CoRNR box...

journal_title：Developmental biology

authors： Malartre M,Short S,Sharpe C

更新日期：2006-04-15 00:00:00

abstract：:We have examined the roles of cell lineage and interactions in the determination of individual identified neurons in the grasshopper embryo by selective ablations of individual cells and/or their neighbors at successive stages following their birth. The neurons in the grasshopper central nervous system (CNS) are produ...

journal_title：Developmental biology

authors： Kuwada JY,Goodman CS

更新日期：1985-07-01 00:00:00

abstract：:Voltage-gated Na(+) and K(+) channels are localized to distinct subcellular domains in mammalian myelinated nerve fibers. Specifically, Na(+) channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal zones just beyond regions of axoglial contact where sequential laye...

journal_title：Developmental biology

authors： Rasband MN,Trimmer JS

更新日期：2001-08-01 00:00:00

abstract：:The Endo16 gene codes for an RGD-containing calcium-binding protein that is found on the basal surfaces and in the extracellular matrix of cells of the invaginating archenteron during sea urchin gastrulation. Previously, we have shown that Endo16 is a single copy gene and we have determined the coding sequence and ana...

journal_title：Developmental biology

authors： Godin RE,Urry LA,Ernst SG

更新日期：1996-10-10 00:00:00

abstract：:Spontaneous germ cell death is a common cellular process in the mammalian testis, although the function of this process during spermatogenesis is unclear. An investigation was undertaken to determine whether p53 serves as a mechanism in germ cell quality control by causing spontaneous germ cell death. Using an annexin...

journal_title：Developmental biology

authors： Yin Y,Stahl BC,DeWolf WC,Morgentaler A

更新日期：1998-12-01 00:00:00

abstract：:To examine the possible role of homeo box genes in murine development we have studied the structure and expression pattern of Hox-2.5, a newly isolated homeo box gene that maps to the left end of the mouse Hox-2 locus on chromosome 11. The sequence of the Hox-2.5 homeo box has been determined. It is highly homologous ...

journal_title：Developmental biology

authors： Bogarad LD,Utset MF,Awgulewitsch A,Miki T,Hart CP,Ruddle FH

更新日期：1989-06-01 00:00:00