The extracellular matrix dimension of skeletal muscle development.

abstract：:Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not presen...

journal_title：Developmental biology

authors： Andersson O,Reissmann E,Jörnvall H,Ibáñez CF

更新日期：2006-05-15 00:00:00

abstract：:Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

journal_title：Developmental biology

authors： Kelsh RN,Schmid B,Eisen JS

更新日期：2000-09-15 00:00:00

abstract：:Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cel...

journal_title：Developmental biology

authors： Mohlin S,Kunttas E,Persson CU,Abdel-Haq R,Castillo A,Murko C,Bronner ME,Kerosuo L

更新日期：2019-03-15 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00

abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

journal_title：Developmental biology

authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

更新日期：2000-11-15 00:00:00

abstract：:Collapsin-1 is a secreted glycoprotein that inhibits the extension of specific growth cones in vitro. It has been hypothesized to serve as a repulsive guidance cue for extending growth cones in vivo. Here we report the distribution of collapsin-1 message as demonstrated by in situ hybridization using digoxigenin-label...

journal_title：Developmental biology

authors： Shepherd I,Luo Y,Raper JA,Chang S

更新日期：1996-01-10 00:00:00

abstract：:Little is known about the genetic basis of behavioral choice, such as temperature preference, especially in natural populations. Thermal preference can play a key role in habitat selection, for example in aquatic species. Examining this behavior on a genetic level requires access to individuals or populations of the s...

journal_title：Developmental biology

authors： Tabin JA,Aspiras A,Martineau B,Riddle M,Kowalko J,Borowsky R,Rohner N,Tabin CJ

更新日期：2018-09-15 00:00:00

abstract：:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for ...

journal_title：Developmental biology

authors： Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R

更新日期：2006-08-01 00:00:00

abstract：:Recent data suggest that dental cells utilize the evolutonarily conserved Notch-mediated intercellular signaling pathway to regulate their fates. Here we report on the expression and regulation of Delta1, a transmembrane ligand of the Notch receptors, during mouse odontogenesis. Delta1 is weakly expressed in dental ep...

journal_title：Developmental biology

authors： Mitsiadis TA,Hirsinger E,Lendahl U,Goridis C

更新日期：1998-12-15 00:00:00

abstract：:The primary lung bud originates from the foregut and develops into the bronchial tree by repetitive branching and outgrowing of the airway. The Sry related HMG box protein Sox2 is expressed in a cyclic manner during initiation and branching morphogenesis of the lung. It is highly expressed in non-branching regions and...

journal_title：Developmental biology

authors： Gontan C,de Munck A,Vermeij M,Grosveld F,Tibboel D,Rottier R

更新日期：2008-05-01 00:00:00

abstract：:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on ...

journal_title：Developmental biology

authors： Jiang SY,Ramamoorthy R,Ramachandran S

更新日期：2008-02-15 00:00:00

abstract：:Non-syndromic mitral valve prolapse (MVP) is the most common heart valve disease affecting 2.4% of the population. Recent studies have identified genetic defects in primary cilia as causative to MVP, although the mechanism of their action is currently unknown. Using a series of gene inactivation approaches, we define ...

journal_title：Developmental biology

authors： Fulmer D,Toomer KA,Glover J,Guo L,Moore K,Moore R,Stairley R,Gensemer C,Abrol S,Rumph MK,Emetu F,Lipschutz JH,McDowell C,Bian J,Wang C,Beck T,Wessels A,Renault MA,Norris RA

更新日期：2020-07-01 00:00:00

abstract：:Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, skin, and intestine. Although human tooth regeneration is limited, a number of animals have evolved continuously growing teeth that provide models of stem cell-based organ renewal. A well-studied model is the mouse incis...

journal_title：Developmental biology

authors： Li CY,Cha W,Luder HU,Charles RP,McMahon M,Mitsiadis TA,Klein OD

更新日期：2012-06-15 00:00:00

abstract：:We have performed a detailed analysis of the expression pattern of the three gnathostome Otx classes in order to gain new insights into their functional evolution. Expression patterns were examined in the developing eye of a chondrichthyan, the dogfish, and an amniote, the chick, and compared with the capacity of para...

journal_title：Developmental biology

authors： Plouhinec JL,Leconte L,Sauka-Spengler T,Bovolenta P,Mazan S,Saule S

更新日期：2005-02-15 00:00:00

abstract：:Vertebrate morphology has been evolutionarily modified by natural and/or artificial selection. The morphological variation of goldfish is a representative example. In particular, the twin-tail strain of ornamental goldfish shows highly diverged anal and caudal fin morphology: bifurcated anal and caudal fins. Recent mo...

journal_title：Developmental biology

authors： Abe G,Ota KG

更新日期：2017-07-15 00:00:00

abstract：:The s-SHIP protein is a shorter isoform of the longer SHIP1 protein and lacks the N-terminal SH2 domain region contained in SHIP1. s-SHIP is expressed in ES cells and in enriched bone marrow stem cells, and may be controlled by a promoter within intron 5 of the ship1 gene. We therefore examined the potential specifici...

journal_title：Developmental biology

authors： Rohrschneider LR,Custodio JM,Anderson TA,Miller CP,Gu H

更新日期：2005-07-15 00:00:00

abstract：:Spermatogenesis is initiated by the interaction of germ cells and somatic cells in seminiferous tubules. We used cDNA microarrays and representational difference analysis to identify genes that are expressed in the testis of the jsd/jsd mutant mouse, which contains only type A spermatogonial germ cells and Sertoli cel...

journal_title：Developmental biology

authors： Tanaka K,Tamura H,Tanaka H,Katoh M,Futamata Y,Seki N,Nishimune Y,Hara T

更新日期：2002-06-15 00:00:00

abstract：:Morphogenesis of the cartilaginous otic capsule is directed by interactions between the epithelial anlage of the membranous labyrinth (otocyst) and its associated periotic mesenchyme. Utilizing a developmental series of high-density (micromass) cultures of periotic mesenchyme to model capsule chondrogenesis, we have s...

journal_title：Developmental biology

authors： Frenz DA,Van De Water TR

更新日期：1991-03-01 00:00:00

abstract：:During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...

journal_title：Developmental biology

authors： Linask KK,Knudsen KA,Gui YH

更新日期：1997-05-15 00:00:00

abstract：:The prostate gland develops from the urogenital sinus by a testosterone-dependent process of ductal morphogenesis. Sonic hedgehog (Shh) is expressed in the urogenital sinus epithelium and the time course of expression coincides with the formation of the main prostatic ducts. Expression is most abundant in the lumen of...

journal_title：Developmental biology

authors： Podlasek CA,Barnett DH,Clemens JQ,Bak PM,Bushman W

更新日期：1999-05-01 00:00:00

abstract：:Retinal stem cells (RSCs) exist as rare pigmented ciliary epithelial cells in adult mammalian eyes. We hypothesized that RSCs are at the top of the retinal cell lineage. Thus, genes expressed early in embryonic development to establish the retinal field in forebrain neuroectoderm may play important roles in RSCs. Pax6...

journal_title：Developmental biology

authors： Xu S,Sunderland ME,Coles BL,Kam A,Holowacz T,Ashery-Padan R,Marquardt T,McInnes RR,van der Kooy D

更新日期：2007-04-15 00:00:00

abstract：:In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and sm...

journal_title：Developmental biology

authors： Li Z,Colucci-Guyon E,Pinçon-Raymond M,Mericskay M,Pournin S,Paulin D,Babinet C

更新日期：1996-05-01 00:00:00

abstract：:Directed cell movement is integral to both embryogenesis and hematopoiesis. In the adult, the chemokine family of secreted proteins signals migration of hematopoietic cells through G-coupled chemokine receptors. We detected embryonic expression of chemokine receptor messages by RT-PCR with degenerate primers at embryo...

journal_title：Developmental biology

authors： McGrath KE,Koniski AD,Maltby KM,McGann JK,Palis J

更新日期：1999-09-15 00:00:00

abstract：:beta-Catenin was originally identified biochemically as a protein that binds E-cadherin in cultured cells and that interaction was later shown to be essential for cadherin function. Independently, armadillo, the beta-catenin homolog in Drosophila melanogaster, was identified as a segment polarity gene necessary for th...

journal_title：Developmental biology

authors： Miller JR,McClay DR

更新日期：1997-12-15 00:00:00

abstract：:The surface of eggs of the ascidian Halocynthia roretzi, observed with SEM, is essentially smooth until immediately before cell division when numerous microvilli appear and remain during cytokinesis. As the dividing blastomeres become closely adherent, however, the microvilli disappear and the eggs recover their smoot...

journal_title：Developmental biology

authors： Satoh N,Deno T

更新日期：1984-04-01 00:00:00

abstract：:Analysis of 262 transgenic mouse pedigrees suggests that about 30% of the mice produced by microinjection of plasmids into pronuclei are mosaic in the germline. This implies that in these lines integration of the foreign DNA occurred after the first round of chromosomal DNA replication. In mosaics resulting from delay...

journal_title：Developmental biology

authors： Wilkie TM,Brinster RL,Palmiter RD

更新日期：1986-11-01 00:00:00

abstract：:We investigated whether the inhibition of proteoglycan synthesis and salivary branching morphogenesis by beta-D-xyloside was related to the deposition and processing of newly synthesized glycosaminoglycans at the basal epithelial surface that correlates with normal branching activity. Forty eight-hour cultures of cont...

journal_title：Developmental biology

authors： Spooner BS,Bassett K,Stokes B

更新日期：1985-05-01 00:00:00

abstract：:The purpose of this study was to examine part of the trophoblast cell multilineage pathway and its modulation by retinoic acid. A method for studying trophoblast cell differentiation along the spongiotrophoblast cell pathway in vitro was established and characterized. Cells were isolated from junctional zones of Day 1...

journal_title：Developmental biology

authors： Lu XJ,Deb S,Soares MJ

更新日期：1994-05-01 00:00:00

abstract：:In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...

journal_title：Developmental biology

authors： Filoni S,Bernardini S,Cannata SM,D'Alessio A

更新日期：1997-07-01 00:00:00

abstract：:Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...

journal_title：Developmental biology

authors： Mitchison TJ,Sedat J

更新日期：1983-09-01 00:00:00