Epithelial control of periotic mesenchyme chondrogenesis.

Abstract:

:Morphogenesis of the cartilaginous otic capsule is directed by interactions between the epithelial anlage of the membranous labyrinth (otocyst) and its associated periotic mesenchyme. Utilizing a developmental series of high-density (micromass) cultures of periotic mesenchyme to model capsule chondrogenesis, we have shown that the early influence of otic epithelium in cultures of 10.5- or 14-gestation day (gd) periotic mesenchyme results in initiation or suppression of chondrogenesis, respectively. Furthermore, we have shown that introduction of otic epithelium at two distinct times during in vitro development to cultures of 10.5-gd mesenchyme cells results first in an initiation and then in an inhibition of their chondrogenic response. These influences of epithelial tissue on chondrogenic differentiation by periotic mesenchyme are not tissue specific but are characterized by temporal selectivity. The ability of otic epithelium to influence chondrogenesis and the competence of the periotic mesenchyme to respond to its signals are dependent upon the developmental stage of both tissues. This study provides conclusive evidence that otic epithelium acts as a developmental "switch" during otic capsule morphogenesis, signaling first the turning on and then the turning off of chondrogenic programs in the responding cephalic mesenchyme.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Frenz DA,Van De Water TR

doi

10.1016/0012-1606(91)90476-j

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

38-46

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(91)90476-J

journal_volume

144

pub_type

杂志文章
  • Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum.

    abstract::Thyroid hormone is a major regulator of postnatal brain development, but the precise molecular mechanisms underlying its action in this organ remain poorly understood. We used microarray analysis to identify new target genes in brain. Thyroid hormone treatment of hypothyroid Pax8(-/-) knockout mice, which lack thyroid...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/s0012-1606(02)00039-8

    authors: Poguet AL,Legrand C,Feng X,Yen PM,Meltzer P,Samarut J,Flamant F

    更新日期:2003-02-15 00:00:00

  • Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.

    abstract::Hedgehog (Hh) proteins and cAMP-dependent protein kinase A (PKA) generally play opposing roles in developmental patterning events. Humans and mice heterozygous for mutations in the sonic hedgehog (Shh) receptor gene patched-1 (ptc1) have an increased incidence of certain types of cancer, including medulloblastoma (MB)...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.10.031

    authors: Lelievre V,Seksenyan A,Nobuta H,Yong WH,Chhith S,Niewiadomski P,Cohen JR,Dong H,Flores A,Liau LM,Kornblum HI,Scott MP,Waschek JA

    更新日期:2008-01-01 00:00:00

  • Evidence for engrailed-independent wingless autoregulation in Drosophila.

    abstract::Proper spatial expression of the wingless (wg) gene in the Drosophila embryonic epidermis is crucial to intrasegmental patterning. Single cell wide wg expression is initiated at the blastoderm stage in response to combinatorial regulation by the pair rule genes. Later, during gastrulation, when the epidermal expressio...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.1243

    authors: Yoffe KB,Manoukian AS,Wilder EL,Brand AH,Perrimon N

    更新日期:1995-08-01 00:00:00

  • Sohlh1 is essential for spermatogonial differentiation.

    abstract::Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (b...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.02.027

    authors: Ballow D,Meistrich ML,Matzuk M,Rajkovic A

    更新日期:2006-06-01 00:00:00

  • Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor.

    abstract::CREB-2 (also called ATF4, TAXREB67, or C/ATF) is an evolutionarily conserved member of the CREB/ATF family of basic-leucine zipper transcription factors. CREB-2 is expressed ubiquitously in the adult mouse and can function as both a transcriptional activator and a repressor. However, little was understood about the no...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2000.9699

    authors: Hettmann T,Barton K,Leiden JM

    更新日期:2000-06-01 00:00:00

  • Position specific binding of a monoclonal antibody in chick limb buds.

    abstract::To analyze the molecular mechanism of the limb pattern formation, we have tried to make monoclonal antibodies against antigens from chick limb buds. We obtained one antibody named AV-1 which recognized a specific region of chick limb buds. AV-1 reacted with the distal portion of the anteroventral mesoderm of only deve...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(86)90337-4

    authors: Ohsugi K,Ide H

    更新日期:1986-10-01 00:00:00

  • Remodeling of insulin producing beta-cells during Xenopus laevis metamorphosis.

    abstract::Insulin-producing beta-cells are present as single cells or in small clusters distributed throughout the pancreas of the Xenopus laevis tadpole. During metamorphic climax when the exocrine pancreas dedifferentiates to progenitor cells, the beta-cells undergo two changes. Insulin mRNA is down regulated at the beginning...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.01.038

    authors: Mukhi S,Horb ME,Brown DD

    更新日期:2009-04-15 00:00:00

  • Lens regeneration in larval Xenopus laevis: experimental analysis of the decline in the regenerative capacity during development.

    abstract::In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8598

    authors: Filoni S,Bernardini S,Cannata SM,D'Alessio A

    更新日期:1997-07-01 00:00:00

  • Satellite-like cells contribute to pax7-dependent skeletal muscle repair in adult zebrafish.

    abstract::Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate sa...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2017.03.004

    authors: Berberoglu MA,Gallagher TL,Morrow ZT,Talbot JC,Hromowyk KJ,Tenente IM,Langenau DM,Amacher SL

    更新日期:2017-04-15 00:00:00

  • Protein tyrosine kinase activity following fertilization is required to complete gastrulation, but not for initial differentiation of endoderm and mesoderm in the sea urchin embryo.

    abstract::The egg activation process functions to implement developmental programs that act much later in embryogenesis. One example of this is the fact that application of protein tyrosine kinase inhibitors to the fertilized sea urchin egg for a 15-min period results in a defect in the gastrulation process occurring over 24 h ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8743

    authors: Livingston BT,VanWinkle CE,Kinsey WH

    更新日期:1998-01-01 00:00:00

  • The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo.

    abstract::The s-SHIP protein is a shorter isoform of the longer SHIP1 protein and lacks the N-terminal SH2 domain region contained in SHIP1. s-SHIP is expressed in ES cells and in enriched bone marrow stem cells, and may be controlled by a promoter within intron 5 of the ship1 gene. We therefore examined the potential specifici...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.04.032

    authors: Rohrschneider LR,Custodio JM,Anderson TA,Miller CP,Gu H

    更新日期:2005-07-15 00:00:00

  • Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination.

    abstract::Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2003.10.029

    authors: Kolotuev I,Podbilewicz B

    更新日期:2004-02-15 00:00:00

  • Slowing of synapse elimination by alpha-bungarotoxin superfusion of the neonatal rabbit soleus muscle.

    abstract::To examine the role of postsynaptic activity in regulating the rate of neuromuscular synapse elimination, contractile activity of neonatal rabbit soleus muscles was decreased by chronic superfusion of alpha-bungarotoxin (alpha-BGT) over their surfaces. Superfusion was begun at 6 days postnatal and continued for a vari...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/s0012-1606(89)80009-0

    authors: Callaway EM,Van Essen DC

    更新日期:1989-02-01 00:00:00

  • Scheduled and unscheduled DNA synthesis during development in conjugating Tetrahymena.

    abstract::Autoradiography has been used to confirm and to extend previous microspectrophotometric studies (Doerder and DeBault, 1975) on the timing of DNA synthesis during conjugation in Tetrahymena thermophila. The majority of DNA synthesis occurs at the expected periods preceding gamete formation and the two postzygotic divis...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90500-8

    authors: Allis CD,Colavito-Shepanski M,Gorovsky MA

    更新日期:1987-12-01 00:00:00

  • The role of the neural crest in patterning of avian cranial skeletal, connective, and muscle tissues.

    abstract::The morphology of skeletal tissues formed in each of the branchial arches of higher vertebrates is unique. In addition to these structures, which are derived from the neural crest, the crest-derived connective tissues and mesodermal muscles also form different patterns in each of the branchial arches. The objective of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(83)90318-4

    authors: Noden DM

    更新日期:1983-03-01 00:00:00

  • Inhibition of protein tyrosine kinase activity disrupts early retinal development.

    abstract::In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2003.10.006

    authors: Li M,Babenko NA,Sakaguchi DS

    更新日期:2004-02-01 00:00:00

  • Defining a large set of full-length clones from a Xenopus tropicalis EST project.

    abstract::Amphibian embryos from the genus Xenopus are among the best species for understanding early vertebrate development and for studying basic cell biological processes. Xenopus, and in particular the diploid Xenopus tropicalis, is also ideal for functional genomics. Understanding the behavior of genes in this accessible m...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.04.023

    authors: Gilchrist MJ,Zorn AM,Voigt J,Smith JC,Papalopulu N,Amaya E

    更新日期:2004-07-15 00:00:00

  • CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra.

    abstract::NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian. CnNK-2 ex...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0321

    authors: Grens A,Gee L,Fisher DA,Bode HR

    更新日期:1996-12-15 00:00:00

  • The roles of Groucho/Tle in left-right asymmetry and Kupffer's vesicle organogenesis.

    abstract::The heart is the first organ to form and function in the vertebrate embryo. Furthermore, differences between the left and right sides of the embryo become first detectable during cardiac development. We observed strong cardiac laterality phenotypes in medaka embryos by manipulating Groucho protein activity. The phenot...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.11.020

    authors: Bajoghli B,Aghaallaei N,Soroldoni D,Czerny T

    更新日期:2007-03-01 00:00:00

  • Induction of early transcription in one-cell mouse embryos by microinjection of the nonhistone chromosomal protein HMG-I.

    abstract::In the mouse embryo, the onset of zygotic transcription occurs at the end of the first cell cycle, upon completion of DNA replication. We show that the nonhistone chromosomal protein HMG-I, whose translocation into the pronuclei of one-cell embryos is linked to this first round of DNA synthesis, plays a critical role ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2000.9668

    authors: Beaujean N,Bouniol-Baly C,Monod C,Kissa K,Jullien D,Aulner N,Amirand C,Debey P,Käs E

    更新日期:2000-05-15 00:00:00

  • The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age.

    abstract::The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(89)90256-x

    authors: Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

    更新日期:1989-12-01 00:00:00

  • Par-1 and Tau regulate the anterior-posterior gradient of microtubules in Drosophila oocytes.

    abstract::The formation of an anterior-posterior (AP) gradient of microtubules in Drosophila oocytes is essential for specification of the AP axis. Proper microtubule organization in the oocyte requires the function of serine/threonine kinase Par-1. The N1S isoform of Par-1 is enriched at the posterior cortex of the oocyte from...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.12.031

    authors: Tian AG,Deng WM

    更新日期:2009-03-15 00:00:00

  • Developmental consequences of mutations in the 84B alpha-tubulin gene of Drosophila melanogaster.

    abstract::Developmental effects of six mutations in the gene encoding the majority of alpha-tubulin in all tissues at all stages of Drosophila melanogaster development have been examined. All six alleles produce at least partially stable alpha 84B protein. In genetic assays, two of these alleles approximate the null condition. ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90211-9

    authors: Matthews KA,Kaufman TC

    更新日期:1987-01-01 00:00:00

  • Unusual organization of desmin intermediate filaments in muscular dysgenesis and TTX-treated myotubes.

    abstract::Cytoskeletal intermediate filaments were studied in muscular dysgenesis (mdg) and tetrodotoxin-treated inactive mouse embryo muscle cultures during myofibrillogenesis. Both muscular dysgenesis and tetrodotoxin-treated muscles are characterized in vitro by a total lack of contractile activity and an abnormal developmen...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(88)90159-5

    authors: Tassin AM,Pinçon-Raymond M,Paulin D,Rieger F

    更新日期:1988-09-01 00:00:00

  • Characterization of somatic embryogenesis initiated from the Arabidopsis shoot apex.

    abstract::Somatic embryogenesis is one of the best examples of the remarkable developmental plasticity of plants, in which committed somatic cells can dedifferentiate and acquire the ability to form an embryo and regenerate an entire plant. In Arabidopsis thaliana, the shoot apices of young seedlings have been reported as an al...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2018.04.023

    authors: Kadokura S,Sugimoto K,Tarr P,Suzuki T,Matsunaga S

    更新日期:2018-10-01 00:00:00

  • GCN5 acetylation is required for craniofacial chondrocyte maturation.

    abstract::Development of the craniofacial structures requires the precise differentiation of cranial neural crest cells into osteoblasts or chondrocytes. Here, we explore the epigenetic and non-epigenetic mechanisms that are required for the development of craniofacial chondrocytes. We previously demonstrated that the acetyltra...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2020.05.006

    authors: Pezoa SA,Artinger KB,Niswander LA

    更新日期:2020-08-01 00:00:00

  • Requirement for ADAMTS-1 in extracellular matrix remodeling during ovarian folliculogenesis and lymphangiogenesis.

    abstract::Murine ovarian folliculogenesis commences after birth involving oocyte growth, somatic cell differentiation and structural remodeling of follicle stromal boundaries. The extracellular metalloproteinase ADAMTS-1 has activity against proteoglycans and collagen and is produced by the granulosa cells of ovarian follicles....

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.10.012

    authors: Brown HM,Dunning KR,Robker RL,Pritchard M,Russell DL

    更新日期:2006-12-15 00:00:00

  • Coordination of skeletal muscle gene expression occurs late in mammalian development.

    abstract::The acquisition of specialized skeletal muscle fiber phenotypes during development is investigated by systematic measurement of the accumulation of 21 contractile protein mRNAs during hindlimb development in the rat and the human. During early myotube formation in both species there is no coordination of expression of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(91)90457-e

    authors: Sutherland CJ,Elsom VL,Gordon ML,Dunwoodie SL,Hardeman EC

    更新日期:1991-07-01 00:00:00

  • Cdx regulates Dll1 in multiple lineages.

    abstract::Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.09.034

    authors: Grainger S,Lam J,Savory JG,Mears AJ,Rijli FM,Lohnes D

    更新日期:2012-01-01 00:00:00

  • Loss of Fgfr2 leads to partial XY sex reversal.

    abstract::In mammals, sex is determined in the bipotential embryonic gonad by a balanced network of gene actions which when altered causes disorders of sexual development (DSD, formerly known as intersex). In the XY gonad, presumptive Sertoli cells begin to differentiate when SRY up-regulates SOX9, which in turn activates FGF9 ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.11.010

    authors: Bagheri-Fam S,Sim H,Bernard P,Jayakody I,Taketo MM,Scherer G,Harley VR

    更新日期:2008-02-01 00:00:00