Cardiovascular lesions and skeletal myopathy in mice lacking desmin.

abstract：:Gastrulation in Xenopus laevis transforms a ball of undifferentiated cells into a well-organized elongated embryo with a distinct body axis, as a result of extensive cell rearrangements and movements. Since cell adhesion is thought to play an important role during tissue morphogenesis, we investigated the potential ro...

journal_title：Developmental biology

authors： Lee CH,Gumbiner BM

更新日期：1995-10-01 00:00:00

abstract：:Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate bord...

journal_title：Developmental biology

authors： Pegge J,Tatsinkam AJ,Rider CC,Bell E

更新日期：2020-04-15 00:00:00

abstract：:We examined the development of epithelial Na+ conductance in 6- and 7-day post coitus (p.c.) preimplantation rabbit embryos using the whole-cell patch-clamp technique on dissociated rabbit trophectodermal cells and by immunocytochemical localization using a polyclonal antibody directed against subunits of an apical ep...

journal_title：Developmental biology

authors： Robinson DH,Bubien JK,Smith PR,Benos DJ

更新日期：1991-10-01 00:00:00

abstract：:High osmolarity, bound water, and hydrostatic pressure contribute to notochord mechanics and its morphogenesis into the nucleus pulposus (NP) compartment of the intervertebral disc. Indeed, the osmoadaptive transcription factor, nuclear factor of activated T-cells 5 (NFAT5 aka TonEBP), is robustly expressed by residen...

journal_title：Developmental biology

authors： Tessier S,Madhu V,Johnson ZI,Shapiro IM,Risbud MV

更新日期：2019-11-15 00:00:00

abstract：:We report periodic movements during erection of Dictyostelium discoideum (Dd) sorocarps. Our observations lead to the working hypothesis that Dd sorocarp erection occurs by two superimposed processes: one periodic, with a modal period of 6 1/2 min, and one continuous. We tentatively identify the periodic process with ...

journal_title：Developmental biology

authors： Durston AJ,Cohen MH,Drage DJ,Potel MJ,Robertson A,Wonio D

更新日期：1976-09-01 00:00:00

abstract：:The chick spinal cord can regenerate following injury until advanced developmental stages. It is conceivable that changes in stem/progenitor cell plasticity contribute to the loss of this capacity, which occurs around E13. We investigated the contribution of proliferation, phenotypic changes in radial glia progenitors...

journal_title：Developmental biology

authors： Whalley K,Gögel S,Lange S,Ferretti P

更新日期：2009-08-15 00:00:00

abstract：:The vertebral column is derived from somites, which are transient segments of the paraxial mesoderm that are present in developing vertebrates. The strict spatial and temporal regulation of somitogenesis is of crucial developmental importance. Signals such as Wnt and FGF play roles in somitogenesis, but details regard...

journal_title：Developmental biology

authors： Wang J,Li S,Chen Y,Ding X

更新日期：2007-04-15 00:00:00

abstract：:The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

journal_title：Developmental biology

authors： Peterkin T,Gibson A,Patient R

更新日期：2007-11-15 00:00:00

abstract：:Differences are demonstrated in the chondrogenic potential of cells derived from the distal and proximal halves of chick wing buds from as early as stage 23, prior to the appearance of overt cartilage differentiation. In high cell density cultures, cells obtained from the distal portions of stage 23 or 24 limb buds ar...

journal_title：Developmental biology

authors： Swalla BJ,Owens EM,Linsenmayer TF,Solursh M

更新日期：1983-05-01 00:00:00

abstract：:The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...

journal_title：Developmental biology

authors： Thomsen MK,Butler CM,Shen MM,Swain A

更新日期：2008-04-15 00:00:00

abstract：:Connective tissue outgrowths of neonatal muscle onto a substratum of bone matrix differentiate into cartilage in response to a bone morphogenetic protein (BMP). The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deac...

journal_title：Developmental biology

authors： Kawamura M,Urist MR

更新日期：1988-12-01 00:00:00

abstract：:In the early Drosophila embryo, Bone morphogenetic protein (BMP) activity is positively and negatively regulated by the BMP-binding proteins Short gastrulation (Sog) and Twisted gastrulation (Tsg). We show here that a similar mechanism operates during crossvein formation, utilizing Sog and a new member of the tsg gene...

journal_title：Developmental biology

authors： Shimmi O,Ralston A,Blair SS,O'Connor MB

更新日期：2005-06-01 00:00:00

abstract：:We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (M...

journal_title：Developmental biology

authors： Kachinsky AM,Dominov JA,Miller JB

更新日期：1994-09-01 00:00:00

abstract：:Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1(tm1(cre)Skm)), in which the Foxg1 coding region was replaced by the Cre gene....

journal_title：Developmental biology

authors： Kawaguchi D,Sahara S,Zembrzycki A,O'Leary DDM

更新日期：2016-04-01 00:00:00

abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

journal_title：Developmental biology

authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

更新日期：2011-04-15 00:00:00

abstract：:Adult tissue stem cells self-renew and differentiate in a way that exactly meets the biological demand of the dependent tissue. We evaluated spermatogonial stem cell (SSC) activity in the developing rat testis and the quality and accessibility of the stem cell niche in wild type, and two busulfan-treated models of rat...

journal_title：Developmental biology

authors： Ryu BY,Orwig KE,Avarbock MR,Brinster RL

更新日期：2003-11-15 00:00:00

abstract：:The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

journal_title：Developmental biology

authors： Dutta S,Dietrich JE,Westerfield M,Varga ZM

更新日期：2008-07-15 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported ...

journal_title：Developmental biology

authors： Dellinger M,Hunter R,Bernas M,Gale N,Yancopoulos G,Erickson R,Witte M

更新日期：2008-07-15 00:00:00

abstract：:The Hippo tumor suppressor pathway plays many fundamental cell biological roles during animal development. Two central players in controlling Hippo-dependent gene expression are the TEAD transcription factor Scalloped (Sd) and its transcriptional co-activator Yorkie (Yki). Hippo signaling phosphorylates Yki, thereby b...

journal_title：Developmental biology

authors： Xie B,Morton DB,Cook TA

更新日期：2019-11-01 00:00:00

abstract：:Vertebrate morphology has been evolutionarily modified by natural and/or artificial selection. The morphological variation of goldfish is a representative example. In particular, the twin-tail strain of ornamental goldfish shows highly diverged anal and caudal fin morphology: bifurcated anal and caudal fins. Recent mo...

journal_title：Developmental biology

authors： Abe G,Ota KG

更新日期：2017-07-15 00:00:00

abstract：:Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

journal_title：Developmental biology

authors： Shin KS,Park JY,Ha DB,Chung CH,Kang MS

更新日期：1996-04-10 00:00:00

abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...

journal_title：Developmental biology

authors： Albertson DG

更新日期：1984-01-01 00:00:00

abstract：:The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, de...

journal_title：Developmental biology

authors： Sefton EM,Gallardo M,Kardon G

更新日期：2018-08-15 00:00:00

abstract：:The early mouse embryo undertakes two types of cell division: symmetric that gives rise to the trophectoderm and then placenta or asymmetric that gives rise to inner cells that generate the embryo proper. Although cell division orientation is important, the mechanism regulating it has remained unclear. Here, we identi...

journal_title：Developmental biology

authors： Ajduk A,Biswas Shivhare S,Zernicka-Goetz M

更新日期：2014-08-15 00:00:00

abstract：:The levels of al-1 and al-2 transcripts change dramatically in response to light and development during the formation of Neurospora crassa asexual spores (conidia). al-1 and al-2 mRNAs accumulate throughout conidiation irrespective of lighting conditions initially at low levels. As conidiation proceeds, two increases ...

journal_title：Developmental biology

authors： Li C,Schmidhauser TJ

更新日期：1995-05-01 00:00:00

abstract：:The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...

journal_title：Developmental biology

authors： Goldhamer DJ,Tomlinson BL,Tassava RA

更新日期：1989-10-01 00:00:00

abstract：:Selected stages of the developing chicken cornea have been examined for type VI collagen, employing monoclonal antibodies specific for this molecule. By immunofluorescence, the molecule is not detectable in 5 1/2 day corneas, a time at which the epithelial-derived, acellular primary stroma is the only corneal matrix p...

journal_title：Developmental biology

authors： Linsenmayer TF,Bruns RR,Mentzer A,Mayne R

更新日期：1986-12-01 00:00:00

abstract：:Krox-20, originally identified as a member of "immediate-early" genes, plays a crucial role in the formation of two specific segments in the hindbrain during early development of the vertebrate nervous system. Here we cloned a genomic sequence of Xenopus Krox-20 (XKrox-20) and studied functions of a promoter element i...

journal_title：Developmental biology

authors： Watanabe T,Hongo I,Kidokoro Y,Okamoto H

更新日期：2005-01-15 00:00:00

abstract：:Gr16 (chromosome 2, 6.9 cM) is a dominant, grey egg mutation of the domestic silkmoth, Bombyx mori, which produces an opaque instead of a translucent chorion. To determine the underlying cause of this defect, we examined the effects of the mutation on chorion ultrastructure, protein accumulation, and biosynthesis patt...

journal_title：Developmental biology

authors： Gautreau D,Zetlan SR,Mazur GD,Goldsmith MR

更新日期：1993-05-01 00:00:00