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Defective remodeling and maturation of the lymphatic vasculature in Angiopoietin-2 deficient mice.

Abstract：

:Molecular mechanisms regulating the remodeling of the lymphatic vasculature from an immature plexus of vessels to a hierarchal network of initial and collecting lymphatics are not well understood. One gene thought to be important for this process is Angiopoietin-2 (Ang-2). Ang2(-/-) mice have previously been reported to exhibit an abnormal lymphatic phenotype but the precise nature of the lymphatic defects and the underlying mechanisms have yet to be defined. Here we demonstrate by whole-mount immunofluorescence staining of ear skin and mesentery that lymphatic vessels in Ang2(-/-) mice fail to mature and do not exhibit a collecting vessel phenotype. Furthermore, dermal lymphatic vessels in Ang2(-/-) pups prematurely recruit smooth muscle cells and do not undergo proper postnatal remodeling. In contrast, Ang2 knock-out Ang1 knock-in mice do develop a hierarchal lymphatic vasculature, suggesting that activation of Tie-2 is required for normal lymphatic development. Taken together, this work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Dellinger M,Hunter R,Bernas M,Gale N,Yancopoulos G,Erickson R,Witte M

doi

10.1016/j.ydbio.2008.04.024

subject

Has Abstract

pub_date

2008-07-15 00:00:00

pages

309-20

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(08)00311-4

journal_volume

319

pub_type

杂志文章

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